Reconstruction of protein domain evolution using single-cell amplified genomes of uncultured choanoflagellates sheds light on the origin of animals

Discussion meeting issue ‘Single cell ecology’ organized and edited by Thomas A. Richards, Ramon Massana and Neil Hall, 10-11 December 2018, The Royal Society, London.-- 19 pages, 5 figures, 3 tables, supplemental material https://royalsocietypublishing.org/doi/suppl/10.1098/rstb.2019.0088.-- Data a...

Descripción completa

Detalles Bibliográficos
Autores: López-Escardó, David, Grau-Bové, Xavier, Guillaumet-Adkins, Amy, Gut, Marta, Sieracki, Michael E., Ruiz-Trillo, Iñaki
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/195232
Acceso en línea:http://hdl.handle.net/10261/195232
Access Level:acceso abierto
Palabra clave:Single-cell genomics
Animal multicellularity
Choanoflagellates
Protein domain evolution
id ES_ef01ea5e6da9638b3cb2d5d42f14d3da
oai_identifier_str oai:digital.csic.es:10261/195232
network_acronym_str ES
network_name_str España
repository_id_str
spelling Reconstruction of protein domain evolution using single-cell amplified genomes of uncultured choanoflagellates sheds light on the origin of animalsLópez-Escardó, DavidGrau-Bové, XavierGuillaumet-Adkins, AmyGut, MartaSieracki, Michael E.Ruiz-Trillo, IñakiSingle-cell genomicsAnimal multicellularityChoanoflagellatesProtein domain evolutionDiscussion meeting issue ‘Single cell ecology’ organized and edited by Thomas A. Richards, Ramon Massana and Neil Hall, 10-11 December 2018, The Royal Society, London.-- 19 pages, 5 figures, 3 tables, supplemental material https://royalsocietypublishing.org/doi/suppl/10.1098/rstb.2019.0088.-- Data accessibility https://doi.org/10.6084/m9.figshare.7819571.v1Understanding the origins of animal multicellularity is a fundamental biological question. Recent genome data have unravelled the role that co-option of pre-existing genes played in the origin of animals. However, there were also some important genetic novelties at the onset of Metazoa. To have a clear understanding of the specific genetic innovations and how they appeared, we need the broadest taxon sampling possible, especially among early-branching animals and their unicellular relatives. Here, we take advantage of single-cell genomics to expand our understanding of the genomic diversity of choanoflagellates, the sister-group to animals. With these genomes, we have performed an updated and taxon-rich reconstruction of protein evolution from the Last Eukaryotic Common Ancestor (LECA) to animals. Our novel data re-defines the origin of some genes previously thought to be metazoan-specific, like the POU transcription factor, which we show appeared earlier in evolution. Moreover, our data indicate that the acquisition of new genes at the stem of Metazoa was mainly driven by duplications and protein domain rearrangement processes at the stem of Metazoa. Furthermore, our analysis allowed us to reveal protein domains that are essential to the maintenance of animal multicellularity. Our analyses also demonstrate the utility of single-cell genomics from uncultured taxa to address evolutionary questionsThis work was supported by a European Research Council Consolidator grant no. (ERC-2012-Co -616960) to I.R.-TPeer ReviewedRoyal Society (Great Britain)European Research CouncilConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2019201920192019info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/195232reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.1098/rstb.2019.0088Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1952322026-05-22T06:33:51Z
dc.title.none.fl_str_mv Reconstruction of protein domain evolution using single-cell amplified genomes of uncultured choanoflagellates sheds light on the origin of animals
title Reconstruction of protein domain evolution using single-cell amplified genomes of uncultured choanoflagellates sheds light on the origin of animals
spellingShingle Reconstruction of protein domain evolution using single-cell amplified genomes of uncultured choanoflagellates sheds light on the origin of animals
López-Escardó, David
Single-cell genomics
Animal multicellularity
Choanoflagellates
Protein domain evolution
title_short Reconstruction of protein domain evolution using single-cell amplified genomes of uncultured choanoflagellates sheds light on the origin of animals
title_full Reconstruction of protein domain evolution using single-cell amplified genomes of uncultured choanoflagellates sheds light on the origin of animals
title_fullStr Reconstruction of protein domain evolution using single-cell amplified genomes of uncultured choanoflagellates sheds light on the origin of animals
title_full_unstemmed Reconstruction of protein domain evolution using single-cell amplified genomes of uncultured choanoflagellates sheds light on the origin of animals
title_sort Reconstruction of protein domain evolution using single-cell amplified genomes of uncultured choanoflagellates sheds light on the origin of animals
dc.creator.none.fl_str_mv López-Escardó, David
Grau-Bové, Xavier
Guillaumet-Adkins, Amy
Gut, Marta
Sieracki, Michael E.
Ruiz-Trillo, Iñaki
author López-Escardó, David
author_facet López-Escardó, David
Grau-Bové, Xavier
Guillaumet-Adkins, Amy
Gut, Marta
Sieracki, Michael E.
Ruiz-Trillo, Iñaki
author_role author
author2 Grau-Bové, Xavier
Guillaumet-Adkins, Amy
Gut, Marta
Sieracki, Michael E.
Ruiz-Trillo, Iñaki
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv European Research Council
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Single-cell genomics
Animal multicellularity
Choanoflagellates
Protein domain evolution
topic Single-cell genomics
Animal multicellularity
Choanoflagellates
Protein domain evolution
description Discussion meeting issue ‘Single cell ecology’ organized and edited by Thomas A. Richards, Ramon Massana and Neil Hall, 10-11 December 2018, The Royal Society, London.-- 19 pages, 5 figures, 3 tables, supplemental material https://royalsocietypublishing.org/doi/suppl/10.1098/rstb.2019.0088.-- Data accessibility https://doi.org/10.6084/m9.figshare.7819571.v1
publishDate 2019
dc.date.none.fl_str_mv 2019
2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/195232
url http://hdl.handle.net/10261/195232
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.1098/rstb.2019.0088
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Royal Society (Great Britain)
publisher.none.fl_str_mv Royal Society (Great Britain)
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869423798514614272
score 15,812429

Similares en LA Referencia