Variability in mutational fitness effects prevents full lethal transitions in large quasispecies populations

The distribution of mutational fitness effects (DMFE) is crucial to the evolutionary fate of quasispecies. In this article we analyze the effect of the DMFE on the dynamics of a large quasispecies by means of a phenotypic version of the classic Eigen's model that incorporates beneficial, neutra...

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Autores: Sardanyés, Josep|||0000-0001-7225-5158, Simó, Carles, Martínez Barchino, Regina|||0000-0002-1328-6744, Solé, Ricard|||0000-0001-6974-1008, Elena, Santiago F.|||0000-0001-8249-5593
Tipo de documento: artigo
Data de publicação:2014
País:España
Recursos:Universitat Autònoma de Barcelona
Repositório:Dipòsit Digital de Documents de la UAB
Idioma:inglês
OAI Identifier:oai:ddd.uab.cat:206005
Acesso em linha:https://ddd.uab.cat/record/206005
https://dx.doi.org/urn:doi:10.1038/srep04625
Access Level:Acceso aberto
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spelling Variability in mutational fitness effects prevents full lethal transitions in large quasispecies populationsSardanyés, Josep|||0000-0001-7225-5158Simó, CarlesMartínez Barchino, Regina|||0000-0002-1328-6744Solé, Ricard|||0000-0001-6974-1008Elena, Santiago F.|||0000-0001-8249-5593The distribution of mutational fitness effects (DMFE) is crucial to the evolutionary fate of quasispecies. In this article we analyze the effect of the DMFE on the dynamics of a large quasispecies by means of a phenotypic version of the classic Eigen's model that incorporates beneficial, neutral, deleterious, and lethal mutations. By parameterizing the model with available experimental data on the DMFE of Vesicular stomatitis virus (VSV) and Tobacco etch virus (TEV), we found that increasing mutation does not totally push the entire viral quasispecies towards deleterious or lethal regions of the phenotypic sequence space. The probability of finding regions in the parameter space of the general model that results in a quasispecies only composed by lethal phenotypes is extremely small at equilibrium and in transient times. The implications of our findings can be extended to other scenarios, such as lethal mutagenesis or genomically unstable cancer, where increased mutagenesis has been suggested as a potential therapy. 22014-01-0120142014-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/206005https://dx.doi.org/urn:doi:10.1038/srep04625reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2060052026-06-06T12:50:31Z
dc.title.none.fl_str_mv Variability in mutational fitness effects prevents full lethal transitions in large quasispecies populations
title Variability in mutational fitness effects prevents full lethal transitions in large quasispecies populations
spellingShingle Variability in mutational fitness effects prevents full lethal transitions in large quasispecies populations
Sardanyés, Josep|||0000-0001-7225-5158
title_short Variability in mutational fitness effects prevents full lethal transitions in large quasispecies populations
title_full Variability in mutational fitness effects prevents full lethal transitions in large quasispecies populations
title_fullStr Variability in mutational fitness effects prevents full lethal transitions in large quasispecies populations
title_full_unstemmed Variability in mutational fitness effects prevents full lethal transitions in large quasispecies populations
title_sort Variability in mutational fitness effects prevents full lethal transitions in large quasispecies populations
dc.creator.none.fl_str_mv Sardanyés, Josep|||0000-0001-7225-5158
Simó, Carles
Martínez Barchino, Regina|||0000-0002-1328-6744
Solé, Ricard|||0000-0001-6974-1008
Elena, Santiago F.|||0000-0001-8249-5593
author Sardanyés, Josep|||0000-0001-7225-5158
author_facet Sardanyés, Josep|||0000-0001-7225-5158
Simó, Carles
Martínez Barchino, Regina|||0000-0002-1328-6744
Solé, Ricard|||0000-0001-6974-1008
Elena, Santiago F.|||0000-0001-8249-5593
author_role author
author2 Simó, Carles
Martínez Barchino, Regina|||0000-0002-1328-6744
Solé, Ricard|||0000-0001-6974-1008
Elena, Santiago F.|||0000-0001-8249-5593
author2_role author
author
author
author
description The distribution of mutational fitness effects (DMFE) is crucial to the evolutionary fate of quasispecies. In this article we analyze the effect of the DMFE on the dynamics of a large quasispecies by means of a phenotypic version of the classic Eigen's model that incorporates beneficial, neutral, deleterious, and lethal mutations. By parameterizing the model with available experimental data on the DMFE of Vesicular stomatitis virus (VSV) and Tobacco etch virus (TEV), we found that increasing mutation does not totally push the entire viral quasispecies towards deleterious or lethal regions of the phenotypic sequence space. The probability of finding regions in the parameter space of the general model that results in a quasispecies only composed by lethal phenotypes is extremely small at equilibrium and in transient times. The implications of our findings can be extended to other scenarios, such as lethal mutagenesis or genomically unstable cancer, where increased mutagenesis has been suggested as a potential therapy.
publishDate 2014
dc.date.none.fl_str_mv 2
2014-01-01
2014
2014-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/206005
https://dx.doi.org/urn:doi:10.1038/srep04625
url https://ddd.uab.cat/record/206005
https://dx.doi.org/urn:doi:10.1038/srep04625
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
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