Neuronal temperature perception induces specific defenses that enable C. elegans to cope with the enhanced reactivity of hydrogen peroxide at high temperature

Hydrogen peroxide is the most common reactive chemical that organisms face on the microbial battlefield. The rate with which hydrogen peroxide damages biomolecules required for life increases with temperature, yet little is known about how organisms cope with this temperature-dependent threat. Here,...

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Autores: Servello, Francesco A., Fernandes, Rute, Eder, Matthias, Harris, Nathan, Martin, Olivier M. F., Oswal, Natasha, Lindberg, Anders, Derosiers, Nohelly, Sengupta, Piali, Stroustrup, Nicholas, Apfeld, Javier
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/55347
Acceso en línea:http://hdl.handle.net/10230/55347
http://dx.doi.org/10.7554/eLife.78941
Access Level:acceso abierto
Palabra clave:C. elegans
E. coli
Enterococcus faecium
Developmental biology
Hydrogen peroxide
Insulin signaling
Neuroscience
Sensory perception
Temperature
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spelling Neuronal temperature perception induces specific defenses that enable C. elegans to cope with the enhanced reactivity of hydrogen peroxide at high temperatureServello, Francesco A.Fernandes, RuteEder, MatthiasHarris, NathanMartin, Olivier M. F.Oswal, NatashaLindberg, AndersDerosiers, NohellySengupta, PialiStroustrup, NicholasApfeld, JavierC. elegansE. coliEnterococcus faeciumDevelopmental biologyHydrogen peroxideInsulin signalingNeuroscienceSensory perceptionTemperatureHydrogen peroxide is the most common reactive chemical that organisms face on the microbial battlefield. The rate with which hydrogen peroxide damages biomolecules required for life increases with temperature, yet little is known about how organisms cope with this temperature-dependent threat. Here, we show that Caenorhabditis elegans nematodes use temperature information perceived by sensory neurons to cope with the temperature-dependent threat of hydrogen peroxide produced by the pathogenic bacterium Enterococcus faecium. These nematodes preemptively induce the expression of specific hydrogen peroxide defenses in response to perception of high temperature by a pair of sensory neurons. These neurons communicate temperature information to target tissues expressing those defenses via an insulin/IGF1 hormone. This is the first example of a multicellular organism inducing their defenses to a chemical when they sense an inherent enhancer of the reactivity of that chemical.eLife202320232022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/55347http://dx.doi.org/10.7554/eLife.78941reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésElife. 2022 Oct 13;11:e78941© 2022, Servello et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/553472026-06-12T07:21:37Z
dc.title.none.fl_str_mv Neuronal temperature perception induces specific defenses that enable C. elegans to cope with the enhanced reactivity of hydrogen peroxide at high temperature
title Neuronal temperature perception induces specific defenses that enable C. elegans to cope with the enhanced reactivity of hydrogen peroxide at high temperature
spellingShingle Neuronal temperature perception induces specific defenses that enable C. elegans to cope with the enhanced reactivity of hydrogen peroxide at high temperature
Servello, Francesco A.
C. elegans
E. coli
Enterococcus faecium
Developmental biology
Hydrogen peroxide
Insulin signaling
Neuroscience
Sensory perception
Temperature
title_short Neuronal temperature perception induces specific defenses that enable C. elegans to cope with the enhanced reactivity of hydrogen peroxide at high temperature
title_full Neuronal temperature perception induces specific defenses that enable C. elegans to cope with the enhanced reactivity of hydrogen peroxide at high temperature
title_fullStr Neuronal temperature perception induces specific defenses that enable C. elegans to cope with the enhanced reactivity of hydrogen peroxide at high temperature
title_full_unstemmed Neuronal temperature perception induces specific defenses that enable C. elegans to cope with the enhanced reactivity of hydrogen peroxide at high temperature
title_sort Neuronal temperature perception induces specific defenses that enable C. elegans to cope with the enhanced reactivity of hydrogen peroxide at high temperature
dc.creator.none.fl_str_mv Servello, Francesco A.
Fernandes, Rute
Eder, Matthias
Harris, Nathan
Martin, Olivier M. F.
Oswal, Natasha
Lindberg, Anders
Derosiers, Nohelly
Sengupta, Piali
Stroustrup, Nicholas
Apfeld, Javier
author Servello, Francesco A.
author_facet Servello, Francesco A.
Fernandes, Rute
Eder, Matthias
Harris, Nathan
Martin, Olivier M. F.
Oswal, Natasha
Lindberg, Anders
Derosiers, Nohelly
Sengupta, Piali
Stroustrup, Nicholas
Apfeld, Javier
author_role author
author2 Fernandes, Rute
Eder, Matthias
Harris, Nathan
Martin, Olivier M. F.
Oswal, Natasha
Lindberg, Anders
Derosiers, Nohelly
Sengupta, Piali
Stroustrup, Nicholas
Apfeld, Javier
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv C. elegans
E. coli
Enterococcus faecium
Developmental biology
Hydrogen peroxide
Insulin signaling
Neuroscience
Sensory perception
Temperature
topic C. elegans
E. coli
Enterococcus faecium
Developmental biology
Hydrogen peroxide
Insulin signaling
Neuroscience
Sensory perception
Temperature
description Hydrogen peroxide is the most common reactive chemical that organisms face on the microbial battlefield. The rate with which hydrogen peroxide damages biomolecules required for life increases with temperature, yet little is known about how organisms cope with this temperature-dependent threat. Here, we show that Caenorhabditis elegans nematodes use temperature information perceived by sensory neurons to cope with the temperature-dependent threat of hydrogen peroxide produced by the pathogenic bacterium Enterococcus faecium. These nematodes preemptively induce the expression of specific hydrogen peroxide defenses in response to perception of high temperature by a pair of sensory neurons. These neurons communicate temperature information to target tissues expressing those defenses via an insulin/IGF1 hormone. This is the first example of a multicellular organism inducing their defenses to a chemical when they sense an inherent enhancer of the reactivity of that chemical.
publishDate 2022
dc.date.none.fl_str_mv 2022
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/55347
http://dx.doi.org/10.7554/eLife.78941
url http://hdl.handle.net/10230/55347
http://dx.doi.org/10.7554/eLife.78941
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Elife. 2022 Oct 13;11:e78941
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv eLife
publisher.none.fl_str_mv eLife
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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