State-Dependent Subnetworks of Parvalbumin-Expressing Interneurons in Neocortex

Brain state determines patterns of spiking output that underlie behavior. In neocortex, brain state is reflected in the spontaneous activity of the network, which is regulated in part by neuromodulatory input from the brain stem and by local inhibition. We find that fast-spiking, parvalbuminexpressi...

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Autores: García-Junco Clemente, Pablo, Tring, Elaine, Ringach, Dario L., Trachtenberg, Joshua T.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/101622
Acceso en línea:https://hdl.handle.net/11441/101622
https://doi.org/10.1016/j.celrep.2019.02.005
Access Level:acceso abierto
Palabra clave:Parvalbumin
Interneurons
Neocortex
Brain
Acetylcholine
Nucleus basalis
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repository_id_str
spelling State-Dependent Subnetworks of Parvalbumin-Expressing Interneurons in NeocortexGarcía-Junco Clemente, PabloTring, ElaineRingach, Dario L.Trachtenberg, Joshua T.ParvalbuminInterneuronsNeocortexBrainAcetylcholineNucleus basalisBrain state determines patterns of spiking output that underlie behavior. In neocortex, brain state is reflected in the spontaneous activity of the network, which is regulated in part by neuromodulatory input from the brain stem and by local inhibition. We find that fast-spiking, parvalbuminexpressing inhibitory neurons, which exert state-dependent control of network gain and spike patterns, cluster into two stable and functionally distinct subnetworks that are differentially engaged by ascending neuromodulation. One group is excited as a function of increased arousal state; this excitation is driven in part by the increase in cortical norepinephrine that occurs when the locus coeruleus is active. A second group is suppressed during movement when acetylcholine is released into the cortex via projections from the nucleus basalis. These data establish the presence of functionally independent subnetworks of Parvalbumin (PV) cells in the upper layers of the neocortex that are differentially engaged by the ascending reticular activating system.NIH United States Department of Health & Human Services National Institutes of Health (NIH) - USA R01 EY023871, R01 EY018322, EB022915Junta de Andalucia P12-CTS-2232Ramon y Cajal programme Spanish Government RYC-2016-19906Cell PressFisiología Médica y Biofísica2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/101622https://doi.org/10.1016/j.celrep.2019.02.005reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésCell Reports, 26 (9)R01 EY023871R01 EY018322EB022915P12-CTS-2232RYC-2016-19906https://doi.org/10.1016/j.celrep. 2019.02.005info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1016222026-06-17T12:51:07Z
dc.title.none.fl_str_mv State-Dependent Subnetworks of Parvalbumin-Expressing Interneurons in Neocortex
title State-Dependent Subnetworks of Parvalbumin-Expressing Interneurons in Neocortex
spellingShingle State-Dependent Subnetworks of Parvalbumin-Expressing Interneurons in Neocortex
García-Junco Clemente, Pablo
Parvalbumin
Interneurons
Neocortex
Brain
Acetylcholine
Nucleus basalis
title_short State-Dependent Subnetworks of Parvalbumin-Expressing Interneurons in Neocortex
title_full State-Dependent Subnetworks of Parvalbumin-Expressing Interneurons in Neocortex
title_fullStr State-Dependent Subnetworks of Parvalbumin-Expressing Interneurons in Neocortex
title_full_unstemmed State-Dependent Subnetworks of Parvalbumin-Expressing Interneurons in Neocortex
title_sort State-Dependent Subnetworks of Parvalbumin-Expressing Interneurons in Neocortex
dc.creator.none.fl_str_mv García-Junco Clemente, Pablo
Tring, Elaine
Ringach, Dario L.
Trachtenberg, Joshua T.
author García-Junco Clemente, Pablo
author_facet García-Junco Clemente, Pablo
Tring, Elaine
Ringach, Dario L.
Trachtenberg, Joshua T.
author_role author
author2 Tring, Elaine
Ringach, Dario L.
Trachtenberg, Joshua T.
author2_role author
author
author
dc.contributor.none.fl_str_mv Fisiología Médica y Biofísica
dc.subject.none.fl_str_mv Parvalbumin
Interneurons
Neocortex
Brain
Acetylcholine
Nucleus basalis
topic Parvalbumin
Interneurons
Neocortex
Brain
Acetylcholine
Nucleus basalis
description Brain state determines patterns of spiking output that underlie behavior. In neocortex, brain state is reflected in the spontaneous activity of the network, which is regulated in part by neuromodulatory input from the brain stem and by local inhibition. We find that fast-spiking, parvalbuminexpressing inhibitory neurons, which exert state-dependent control of network gain and spike patterns, cluster into two stable and functionally distinct subnetworks that are differentially engaged by ascending neuromodulation. One group is excited as a function of increased arousal state; this excitation is driven in part by the increase in cortical norepinephrine that occurs when the locus coeruleus is active. A second group is suppressed during movement when acetylcholine is released into the cortex via projections from the nucleus basalis. These data establish the presence of functionally independent subnetworks of Parvalbumin (PV) cells in the upper layers of the neocortex that are differentially engaged by the ascending reticular activating system.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/101622
https://doi.org/10.1016/j.celrep.2019.02.005
url https://hdl.handle.net/11441/101622
https://doi.org/10.1016/j.celrep.2019.02.005
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Cell Reports, 26 (9)
R01 EY023871
R01 EY018322
EB022915
P12-CTS-2232
RYC-2016-19906
https://doi.org/10.1016/j.celrep. 2019.02.005
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Cell Press
publisher.none.fl_str_mv Cell Press
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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