Increased COVID-19 mortality in people with previous cerebrovascular disease: a population-based cohort study

Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Ictus hemorràgic; Ictus isquèmic; Hemorràgia subaracnoidea

Detalhes bibliográficos
Autores: Cuadrado-Godia, Elisa, Grau, Maria, Boher-Massaguer, Marc, Rodríguez Campello, Ana, Giralt Steinhauer, Eva, Fernandez-Perez, Isabel, Jiménez-Conde, Jordi, Roquer Gonzalez, Jaume, Ois, Angel, Martínez-Carbonell, Elisenda, Lazcano, Uxue, Subirana, Isaac
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:11351/7367
Acesso em linha:https://hdl.handle.net/11351/7367
Access Level:acceso abierto
Palavra-chave:COVID-19 (Malaltia) - Mortalitat
Malalties cerebrovasculars - Epidemiologia
DISEASES::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections
Other subheadings::Other subheadings::Other subheadings::Other subheadings::/mortality
DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders
Other subheadings::Other subheadings::Other subheadings::/epidemiology
ENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus
Otros calificadores::Otros calificadores::Otros calificadores::Otros calificadores::/mortalidad
ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares
Otros calificadores::Otros calificadores::Otros calificadores::/epidemiología
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network_name_str España
repository_id_str
dc.title.none.fl_str_mv Increased COVID-19 mortality in people with previous cerebrovascular disease: a population-based cohort study
title Increased COVID-19 mortality in people with previous cerebrovascular disease: a population-based cohort study
spellingShingle Increased COVID-19 mortality in people with previous cerebrovascular disease: a population-based cohort study
Cuadrado-Godia, Elisa
COVID-19 (Malaltia) - Mortalitat
Malalties cerebrovasculars - Epidemiologia
DISEASES::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections
Other subheadings::Other subheadings::Other subheadings::Other subheadings::/mortality
DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders
Other subheadings::Other subheadings::Other subheadings::/epidemiology
ENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus
Otros calificadores::Otros calificadores::Otros calificadores::Otros calificadores::/mortalidad
ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares
Otros calificadores::Otros calificadores::Otros calificadores::/epidemiología
title_short Increased COVID-19 mortality in people with previous cerebrovascular disease: a population-based cohort study
title_full Increased COVID-19 mortality in people with previous cerebrovascular disease: a population-based cohort study
title_fullStr Increased COVID-19 mortality in people with previous cerebrovascular disease: a population-based cohort study
title_full_unstemmed Increased COVID-19 mortality in people with previous cerebrovascular disease: a population-based cohort study
title_sort Increased COVID-19 mortality in people with previous cerebrovascular disease: a population-based cohort study
dc.creator.none.fl_str_mv Cuadrado-Godia, Elisa
Grau, Maria
Boher-Massaguer, Marc
Rodríguez Campello, Ana
Giralt Steinhauer, Eva
Fernandez-Perez, Isabel
Jiménez-Conde, Jordi
Roquer Gonzalez, Jaume
Ois, Angel
Martínez-Carbonell, Elisenda
Lazcano, Uxue
Subirana, Isaac
author Cuadrado-Godia, Elisa
author_facet Cuadrado-Godia, Elisa
Grau, Maria
Boher-Massaguer, Marc
Rodríguez Campello, Ana
Giralt Steinhauer, Eva
Fernandez-Perez, Isabel
Jiménez-Conde, Jordi
Roquer Gonzalez, Jaume
Ois, Angel
Martínez-Carbonell, Elisenda
Lazcano, Uxue
Subirana, Isaac
author_role author
author2 Grau, Maria
Boher-Massaguer, Marc
Rodríguez Campello, Ana
Giralt Steinhauer, Eva
Fernandez-Perez, Isabel
Jiménez-Conde, Jordi
Roquer Gonzalez, Jaume
Ois, Angel
Martínez-Carbonell, Elisenda
Lazcano, Uxue
Subirana, Isaac
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv [Lazcano U] Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Institut d'investigacions mèdiques Hospital del Mar, Barcelona, Spain. Agència de Qualitat i Avaluació Sanitàries de Catalunya (AQuAS), Departament de Salut, Generalitat de Catalunya, Barcelona, Spain. [Cuadrado-Godia E, Rodríguez-Campello A, Giralt-Steinhauer E, Fernández-Pérez I, Jiménez-Conde J, Roquer J, Ois A] Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Institut d'investigacions mèdiques Hospital del Mar, Barcelona, Spain. Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Institut d'investigacions mèdiques Hospital del Mar, Barcelona, Spain. Departament de Neurologia, Hospital del Mar, Departament de Medicina i Ciències de la Vida (CEXS), Universitat Pompeu Fabra, Universitat Autònoma de Barcelona, Barcelona, Spain. [Grau M] Consorcio Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Barcelona, Spain. Department of Medicine, University of Barcelona, Spain. [Subirana I] Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Institut d'investigacions mèdiques Hospital del Mar, Barcelona, Spain. Consorcio Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Barcelona, Spain. [Martínez-Carbonell E] Agència de Qualitat i Avaluació Sanitàries de Catalunya (AQuAS), Departament de Salut, Generalitat de Catalunya, Barcelona, Spain. [Boher-Massaguer M] Agència de Qualitat i Avaluació Sanitàries de Catalunya (AQuAS), Departament de Salut, Generalitat de Catalunya, Barcelona, Spain
Departament de Salut
dc.subject.none.fl_str_mv COVID-19 (Malaltia) - Mortalitat
Malalties cerebrovasculars - Epidemiologia
DISEASES::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections
Other subheadings::Other subheadings::Other subheadings::Other subheadings::/mortality
DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders
Other subheadings::Other subheadings::Other subheadings::/epidemiology
ENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus
Otros calificadores::Otros calificadores::Otros calificadores::Otros calificadores::/mortalidad
ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares
Otros calificadores::Otros calificadores::Otros calificadores::/epidemiología
topic COVID-19 (Malaltia) - Mortalitat
Malalties cerebrovasculars - Epidemiologia
DISEASES::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections
Other subheadings::Other subheadings::Other subheadings::Other subheadings::/mortality
DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular Disorders
Other subheadings::Other subheadings::Other subheadings::/epidemiology
ENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus
Otros calificadores::Otros calificadores::Otros calificadores::Otros calificadores::/mortalidad
ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovasculares
Otros calificadores::Otros calificadores::Otros calificadores::/epidemiología
description Coronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Ictus hemorràgic; Ictus isquèmic; Hemorràgia subaracnoidea
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/7367
url https://hdl.handle.net/11351/7367
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Stroke;53(4)
https://doi.org/10.1161/STROKEAHA.121.036257
dc.rights.none.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Lippincott, Williams & Wilkins 
publisher.none.fl_str_mv Lippincott, Williams & Wilkins 
dc.source.none.fl_str_mv Scientia
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869423793207771136
spelling Increased COVID-19 mortality in people with previous cerebrovascular disease: a population-based cohort studyCuadrado-Godia, ElisaGrau, MariaBoher-Massaguer, MarcRodríguez Campello, AnaGiralt Steinhauer, EvaFernandez-Perez, IsabelJiménez-Conde, JordiRoquer Gonzalez, JaumeOis, AngelMartínez-Carbonell, ElisendaLazcano, UxueSubirana, IsaacCOVID-19 (Malaltia) - MortalitatMalalties cerebrovasculars - EpidemiologiaDISEASES::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus InfectionsOther subheadings::Other subheadings::Other subheadings::Other subheadings::/mortalityDISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Cerebrovascular DisordersOther subheadings::Other subheadings::Other subheadings::/epidemiologyENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por CoronavirusOtros calificadores::Otros calificadores::Otros calificadores::Otros calificadores::/mortalidadENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::trastornos cerebrovascularesOtros calificadores::Otros calificadores::Otros calificadores::/epidemiologíaCoronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Ictus hemorràgic; Ictus isquèmic; Hemorràgia subaracnoideaCoronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Ictus hemorrágico; Ictus isquémico; Hemorragia subaracnoideaCoronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Hemorrhagic stroke; Ischemic stroke; Subarachnoid hemorrhageBackground: The aim of the study was to determine the association between previous stroke and mortality after coronavirus disease 2019 (COVID-19) according to sex, age groups, and stroke subtypes. Methods: Prospective population-based cohort study including all COVID-19 positive cases between February 1 and July 31, 2020. Comorbidities and mortality were extracted using linked health administration databases. Previous stroke included transient ischemic attack, ischemic stroke, hemorrhagic stroke, spontaneous subarachnoid hemorrhage, and combined stroke for cases with more than one category. Other comorbidities were obesity, diabetes, hypertension, ischemic heart disease, atrial fibrillation, heart failure, chronic obstructive pulmonary disease, chronic kidney disease, cirrhosis, dementia, individual socioeconomic index, and deprivation index. Cases were followed up until December 31, 2020. Primary outcome was mortality of any cause after COVID-19 positivity. Cox proportional regression analysis adjusted for comorbidities was used. Stratified analyses were performed for sex and age (<60, 60-79, and ≥80 years). Results: There were 91 629 COVID-19 cases. Previous strokes were 5752 (6.27%), of which 3887 (67.57%) were ischemic, 1237 (21.50%) transient ischemic attack, 255 (4.43%) combined, 203 (3.53%) hemorrhagic, and 170 (2.96%) subarachnoid hemorrhage. There were 9512 deaths (10.38%). Mortality was associated with previous stroke (hazard ratio [HR]=1.12 [95% CI, 1.06-1.18]; P<0.001), in both sexes separately (men=1.13 [1.05-1.22]; P=0.001; women=1.09 [1.01-1.18]; P=0.023), in people <60 years (HR=2.97 [1.97-4.48]; P<0.001) and 60 to 79 years (HR=1.32 [1.19-1.48]; P<0.001) but not in people ≥80 years (HR=1.02 [0.96-1.09]; P=0.437). Ischemic (HR=1.11 [1.05-1.18]; P=0.001), hemorrhagic (HR=1.53 [1.20-1.96]; P=0.001) and combined (HR=1.31 [1.05-1.63]; P=0.016) strokes were associated but not transient ischemic attack. Subarachnoid hemorrhage was associated only in people <60 years (HR=5.73 [1.82-18.06]; P=0.003). Conclusions: Previous stroke was associated with a higher mortality in people younger than 80 years. The association occurred for both ischemic and hemorrhagic stroke but not for transient ischemic attack. These data might help healthcare authorities to establish prioritization strategies for COVID-19 vaccination.This work was supported, in part, by Spain’s Ministry of Health (Instituto de Salud Carlos III FEDER, RD16/0019/0002 and RD16/0019/0010 INVICTUS-PLUS)Lippincott, Williams & Wilkins [Lazcano U] Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Institut d'investigacions mèdiques Hospital del Mar, Barcelona, Spain. Agència de Qualitat i Avaluació Sanitàries de Catalunya (AQuAS), Departament de Salut, Generalitat de Catalunya, Barcelona, Spain. [Cuadrado-Godia E, Rodríguez-Campello A, Giralt-Steinhauer E, Fernández-Pérez I, Jiménez-Conde J, Roquer J, Ois A] Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Institut d'investigacions mèdiques Hospital del Mar, Barcelona, Spain. Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Institut d'investigacions mèdiques Hospital del Mar, Barcelona, Spain. Departament de Neurologia, Hospital del Mar, Departament de Medicina i Ciències de la Vida (CEXS), Universitat Pompeu Fabra, Universitat Autònoma de Barcelona, Barcelona, Spain. [Grau M] Consorcio Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Barcelona, Spain. Department of Medicine, University of Barcelona, Spain. [Subirana I] Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Institut d'investigacions mèdiques Hospital del Mar, Barcelona, Spain. Consorcio Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Barcelona, Spain. [Martínez-Carbonell E] Agència de Qualitat i Avaluació Sanitàries de Catalunya (AQuAS), Departament de Salut, Generalitat de Catalunya, Barcelona, Spain. [Boher-Massaguer M] Agència de Qualitat i Avaluació Sanitàries de Catalunya (AQuAS), Departament de Salut, Generalitat de Catalunya, Barcelona, SpainDepartament de Salut202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/7367Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésStroke;53(4)https://doi.org/10.1161/STROKEAHA.121.036257Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:11351/73672026-05-29T05:05:01Z
score 15.812429

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