Gut Microbiota Metabolism of Bile Acids Could Contribute to the Bariatric Surgery Improvements in Extreme Obesity

Bariatric surgery is the only procedure to obtain and maintain weight loss in the long term, although the mechanisms driving these benefits are not completely understood. In the last years, gut microbiota has emerged as one of the drivers through its metabolites, especially secondary bile acids. In...

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Detalhes bibliográficos
Autores: Ocaña-Wilhelmi, Luis, Martín-Núñez, Gracia María, Ruiz-Limón, Patricia, Alcaide, Juan, García-Fuentes, Eduardo, Gutiérrez-Repiso, Carolina, Tinahones, Francisco J., Moreno-Indias, Isabel
Formato: artículo
Fecha de publicación:2021
País:España
Recursos:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/18490
Acesso em linha:http://hdl.handle.net/20.500.12105/18490
Access Level:acceso abierto
Palavra-chave:Bile acids
Bariatric surgery
Gut microbiota
Enterobacteriaceae
Ácidos y sales biliares
Cirugía bariátrica
Microbioma gastrointestinal
Probióticos
Obesidad
Bariatric Surgery
Obesity, Morbid
Veillonella
Gastrectomy
Weight Loss
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spelling Gut Microbiota Metabolism of Bile Acids Could Contribute to the Bariatric Surgery Improvements in Extreme ObesityOcaña-Wilhelmi, LuisMartín-Núñez, Gracia MaríaRuiz-Limón, PatriciaAlcaide, JuanGarcía-Fuentes, EduardoGutiérrez-Repiso, CarolinaTinahones, Francisco J.Moreno-Indias, IsabelBile acidsBariatric surgeryGut microbiotaEnterobacteriaceaeÁcidos y sales biliaresCirugía bariátricaMicrobioma gastrointestinalProbióticosObesidadBariatric SurgeryObesity, MorbidVeillonellaGastrectomyWeight LossBariatric surgery is the only procedure to obtain and maintain weight loss in the long term, although the mechanisms driving these benefits are not completely understood. In the last years, gut microbiota has emerged as one of the drivers through its metabolites, especially secondary bile acids. In the current study, we have compared the gut microbiota and the bile acid pool, as well as anthropometric and biochemical parameters, of patient with morbid obesity who underwent bariatric surgery by two different techniques, namely Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG). Gut microbiota populations differed after the respective procedures, particularly with respect to the Enterobacteriaceae family. Both techniques resulted in changes in the bile acids pool, but RYGB was the procedure which suffered the greatest changes, with a reduction in most of their levels. Blautia and Veillonella were the two genera that more relationships showed with secondary bile acids, indicating a possible role in their formation and inhibition, respectively. Correlations with the anthropometric and biochemical variables showed that secondary bile acids could have a role in the amelioration of the glucose and HDL-cholesterol levels. Thus, we have observed a possible relationship between the interaction of the bile acids pool metabolized by the gut microbiota in the metabolic improvements obtained by bariatric surgery in the frame of morbid obesity, deserving further investigation in greater cohorts to decipher the role of each bile acid in the homeostasis of the host for their possible use in the development of microbiota-based therapeutics, such as new drugs, postbiotics or probiotics.Multidisciplinary Digital Publishing Institute (MDPI)[Ocaña-Wilhelmi,L] Departamento de Especialidades Quirúrgicas, Bioquímica e Inmunología, Universidad de Málaga, Málaga, Spain. [Ocaña-Wilhelmi,L] Unidad de Gestión Clínica de Cirugía General y del Aparato Digestivo, Hospital Universitario Virgen de la Victoria, Málaga, Spain. [Martín-Núñez,GM; , Ruiz-Limón,P; Alcaide,J; Gutiérrez-Repisom,C; Tinahones,FJ; Moreno-Indias,I] Department of Endocrinology and Nutrition, Virgen de la Victoria Hospital, Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga University, Málaga, Spain. [Martín-Núñez,GM; , Ruiz-Limón,P; Alcaide,J; Gutiérrez-Repisom,C; Tinahones,FJ; Moreno-Indias,I] Centro de Investigación Biomédica en Red de la Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. [García-Fuentes,E] Department of Gastroenterology, Virgen de la Victoria University Hospital, Institute of Biomedical Research in Málaga (IBIMA), Málaga University, Málaga, Spain. [García-Fuentes,E] CIBER Enfermedades Hepáticas y Digestivas-CIBEREHD, Instituto de Salud Carlos III, Madrid, Spain.20242024-02-1920212021-10-2720212021-10-27research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://hdl.handle.net/20.500.12105/18490reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/184902026-06-12T12:43:37Z
dc.title.none.fl_str_mv Gut Microbiota Metabolism of Bile Acids Could Contribute to the Bariatric Surgery Improvements in Extreme Obesity
title Gut Microbiota Metabolism of Bile Acids Could Contribute to the Bariatric Surgery Improvements in Extreme Obesity
spellingShingle Gut Microbiota Metabolism of Bile Acids Could Contribute to the Bariatric Surgery Improvements in Extreme Obesity
Ocaña-Wilhelmi, Luis
Bile acids
Bariatric surgery
Gut microbiota
Enterobacteriaceae
Ácidos y sales biliares
Cirugía bariátrica
Microbioma gastrointestinal
Probióticos
Obesidad
Bariatric Surgery
Obesity, Morbid
Veillonella
Gastrectomy
Weight Loss
title_short Gut Microbiota Metabolism of Bile Acids Could Contribute to the Bariatric Surgery Improvements in Extreme Obesity
title_full Gut Microbiota Metabolism of Bile Acids Could Contribute to the Bariatric Surgery Improvements in Extreme Obesity
title_fullStr Gut Microbiota Metabolism of Bile Acids Could Contribute to the Bariatric Surgery Improvements in Extreme Obesity
title_full_unstemmed Gut Microbiota Metabolism of Bile Acids Could Contribute to the Bariatric Surgery Improvements in Extreme Obesity
title_sort Gut Microbiota Metabolism of Bile Acids Could Contribute to the Bariatric Surgery Improvements in Extreme Obesity
dc.creator.none.fl_str_mv Ocaña-Wilhelmi, Luis
Martín-Núñez, Gracia María
Ruiz-Limón, Patricia
Alcaide, Juan
García-Fuentes, Eduardo
Gutiérrez-Repiso, Carolina
Tinahones, Francisco J.
Moreno-Indias, Isabel
author Ocaña-Wilhelmi, Luis
author_facet Ocaña-Wilhelmi, Luis
Martín-Núñez, Gracia María
Ruiz-Limón, Patricia
Alcaide, Juan
García-Fuentes, Eduardo
Gutiérrez-Repiso, Carolina
Tinahones, Francisco J.
Moreno-Indias, Isabel
author_role author
author2 Martín-Núñez, Gracia María
Ruiz-Limón, Patricia
Alcaide, Juan
García-Fuentes, Eduardo
Gutiérrez-Repiso, Carolina
Tinahones, Francisco J.
Moreno-Indias, Isabel
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv [Ocaña-Wilhelmi,L] Departamento de Especialidades Quirúrgicas, Bioquímica e Inmunología, Universidad de Málaga, Málaga, Spain. [Ocaña-Wilhelmi,L] Unidad de Gestión Clínica de Cirugía General y del Aparato Digestivo, Hospital Universitario Virgen de la Victoria, Málaga, Spain. [Martín-Núñez,GM; , Ruiz-Limón,P; Alcaide,J; Gutiérrez-Repisom,C; Tinahones,FJ; Moreno-Indias,I] Department of Endocrinology and Nutrition, Virgen de la Victoria Hospital, Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga University, Málaga, Spain. [Martín-Núñez,GM; , Ruiz-Limón,P; Alcaide,J; Gutiérrez-Repisom,C; Tinahones,FJ; Moreno-Indias,I] Centro de Investigación Biomédica en Red de la Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. [García-Fuentes,E] Department of Gastroenterology, Virgen de la Victoria University Hospital, Institute of Biomedical Research in Málaga (IBIMA), Málaga University, Málaga, Spain. [García-Fuentes,E] CIBER Enfermedades Hepáticas y Digestivas-CIBEREHD, Instituto de Salud Carlos III, Madrid, Spain.
dc.subject.none.fl_str_mv Bile acids
Bariatric surgery
Gut microbiota
Enterobacteriaceae
Ácidos y sales biliares
Cirugía bariátrica
Microbioma gastrointestinal
Probióticos
Obesidad
Bariatric Surgery
Obesity, Morbid
Veillonella
Gastrectomy
Weight Loss
topic Bile acids
Bariatric surgery
Gut microbiota
Enterobacteriaceae
Ácidos y sales biliares
Cirugía bariátrica
Microbioma gastrointestinal
Probióticos
Obesidad
Bariatric Surgery
Obesity, Morbid
Veillonella
Gastrectomy
Weight Loss
description Bariatric surgery is the only procedure to obtain and maintain weight loss in the long term, although the mechanisms driving these benefits are not completely understood. In the last years, gut microbiota has emerged as one of the drivers through its metabolites, especially secondary bile acids. In the current study, we have compared the gut microbiota and the bile acid pool, as well as anthropometric and biochemical parameters, of patient with morbid obesity who underwent bariatric surgery by two different techniques, namely Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG). Gut microbiota populations differed after the respective procedures, particularly with respect to the Enterobacteriaceae family. Both techniques resulted in changes in the bile acids pool, but RYGB was the procedure which suffered the greatest changes, with a reduction in most of their levels. Blautia and Veillonella were the two genera that more relationships showed with secondary bile acids, indicating a possible role in their formation and inhibition, respectively. Correlations with the anthropometric and biochemical variables showed that secondary bile acids could have a role in the amelioration of the glucose and HDL-cholesterol levels. Thus, we have observed a possible relationship between the interaction of the bile acids pool metabolized by the gut microbiota in the metabolic improvements obtained by bariatric surgery in the frame of morbid obesity, deserving further investigation in greater cohorts to decipher the role of each bile acid in the homeostasis of the host for their possible use in the development of microbiota-based therapeutics, such as new drugs, postbiotics or probiotics.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-10-27
2021
2021-10-27
2024
2024-02-19
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/18490
url http://hdl.handle.net/20.500.12105/18490
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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