Real-Life Impact of Glucocorticoid Treatment in COVID-19 Mortality: A Multicenter Retrospective Study

We aimed to determine the impact of steroid use in COVID-19 in-hospital mortality, in a retrospective cohort study of the SEMICOVID19 database of admitted patients with SARS-CoV-2 laboratory-confirmed pneumonia from 131 Spanish hospitals. Patients treated with corticosteroids were compared to patien...

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Detalles Bibliográficos
Autores: Munoz-Gomez, A, Fernandez-Cruz, A, Lavilla-Olleros, C, Giner-Galvan, V, Ausin-Garcia, C, Wikman, P, Bendala-Estrada, AD, Vargas, JA, Rubio-Rivas, M, Laureiro, J, Fernandez-Bermudez, D, Buonaiuto, VA, de Larriva, AAP, Pascual-Perez, MD, Alcala-Pedrajas, JN, Ruiz, ALI, Hernandez-Milian, A, del Mazo, MG, Antequera, B, Mella-Perez, C, Navas-Alcantara, MD, Soto-Delgado, JF, Gamez-Mancera, RM, Sardina-Gonzalez, C, Meijide-Miguez, H, Ramos-Rincon, JM, Gomez-Huelgas, R, Network
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
Repositorio:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
OAI Identifier:oai:isabial.fundanetsuite.com:p8362
Acceso en línea:https://isabial.portalinvestigacion.com/publicaciones8362
Access Level:acceso abierto
Palabra clave:corticosteroids
SARS-CoV-2
COVID-19
mortality
Descripción
Sumario:We aimed to determine the impact of steroid use in COVID-19 in-hospital mortality, in a retrospective cohort study of the SEMICOVID19 database of admitted patients with SARS-CoV-2 laboratory-confirmed pneumonia from 131 Spanish hospitals. Patients treated with corticosteroids were compared to patients not treated with corticosteroids; and adjusted using a propensity-score for steroid treatment. From March-July 2020, 5.262 (35.26%) were treated with corticosteroids and 9.659 (64.73%) were not. In-hospital mortality overall was 20.50%; it was higher in patients treated with corticosteroids than in controls (28.5% versus 16.2%, OR 2.068 [95% confidence interval; 1.908 to 2.242]; p = 0.0001); however, when adjusting by occurrence of ARDS, mortality was significantly lower in the steroid group (43.4% versus 57.6%; OR 0.564 [95% confidence interval; 0.503 to 0.633]; p = 0.0001). Moreover, the greater the respiratory failure, the greater the impact on mortality of the steroid treatment. When adjusting these results including the propensity score as a covariate, in-hospital mortality remained significantly lower in the steroid group (OR 0.774 [0.660 to 0.907], p = 0.002). Steroid treatment reduced mortality by 24% relative to no steroid treatment (RRR 0.24). These results support the use of glucocorticoids in COVID-19 in this subgroup of patients.</p>

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