Effect of defunctionalization on colon carcinogenesis in the rat

Objective: to examine the effect of fecal absence on experimental colon carcinogenesis in both male and female rats. Material and methods: a total of 138 10-week-old Sprague- Dawley, male and female rats were divided into five groups: A) 20 rats, no treatment; B) 26 rats, colonic defunctionalization...

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Autores: Pérez-Holanda Fernández, Sergio, Rodrigo, Luis, Viñas Salas, Joan, Piñol Felis, Carme, Ildefonso, C.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2006
País:España
Institución:Universitat de Lleida (UdL)
Repositorio:Repositori Obert UdL
OAI Identifier:oai:repositori.udl.cat:10459.1/49278
Acceso en línea:http://hdl.handle.net/10459.1/49278
Access Level:acceso abierto
Palabra clave:Cancer
Carcinogenesis
Colon
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spelling Effect of defunctionalization on colon carcinogenesis in the ratPérez-Holanda Fernández, SergioRodrigo, LuisViñas Salas, JoanPiñol Felis, CarmeIldefonso, C.CancerCarcinogenesisColonObjective: to examine the effect of fecal absence on experimental colon carcinogenesis in both male and female rats. Material and methods: a total of 138 10-week-old Sprague- Dawley, male and female rats were divided into five groups: A) 20 rats, no treatment; B) 26 rats, colonic defunctionalization; C) 30 rats, 18 weekly doses of dimethylhydrazine (DMH), 21 mg/kg body weight each, from the beginning of the study; D) 20 rats, ethylen-diamine-tetraacetic acid for 18 weeks; and E) 42 rats, same surgical procedure as rats in group B plus DMH injections at the same doses as rats in group C. Animals were sacrificed after 25-27 weeks. Number of tumors, their location, and pathological findings were all compared between groups. Results: no tumors developed in the dimethylhydrazine-free groups. No differences were obtained either in number of tumors or tumors per rat for group C as compared to group E. Fecal absence was associated with smaller-sized tumors (p = 0.007), greater numbers of non-mucinous tumors (p = 0.00009), better differentiation (p = 0.0054), and lesser penetration into the wall (p = 0.015) for group E as compared to group C. In the dimethylhydrazine group, fecal absence altered the number of tumors developing in males as compared to female rats (p = 0.025). Moreover, this fecal absence showed no inhibitory effect on right colonic tumors (p = 0.0065). Conclusions: fecal absence alters the DMH-carcinogenic pattern in the defunctionalized colon when using an experimental model in both male and female rats.Sociedad Española de Patología DigestivaArán Ediciones2006info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10459.1/49278reponame:Repositori Obert UdL instname:Universitat de Lleida (UdL)InglésReproducció del document publicat a http://scielo.isciii.es/scielo.php?pid=S1130-01082006000900002&script=sci_arttextRevista Española de Enfermedades Digestivas, 2006, vol. 98, núm. 8, p. 644-649(c) Arán Ediciones, 2006info:eu-repo/semantics/openAccessoai:repositori.udl.cat:10459.1/492782026-06-24T12:42:17Z
dc.title.none.fl_str_mv Effect of defunctionalization on colon carcinogenesis in the rat
title Effect of defunctionalization on colon carcinogenesis in the rat
spellingShingle Effect of defunctionalization on colon carcinogenesis in the rat
Pérez-Holanda Fernández, Sergio
Cancer
Carcinogenesis
Colon
title_short Effect of defunctionalization on colon carcinogenesis in the rat
title_full Effect of defunctionalization on colon carcinogenesis in the rat
title_fullStr Effect of defunctionalization on colon carcinogenesis in the rat
title_full_unstemmed Effect of defunctionalization on colon carcinogenesis in the rat
title_sort Effect of defunctionalization on colon carcinogenesis in the rat
dc.creator.none.fl_str_mv Pérez-Holanda Fernández, Sergio
Rodrigo, Luis
Viñas Salas, Joan
Piñol Felis, Carme
Ildefonso, C.
author Pérez-Holanda Fernández, Sergio
author_facet Pérez-Holanda Fernández, Sergio
Rodrigo, Luis
Viñas Salas, Joan
Piñol Felis, Carme
Ildefonso, C.
author_role author
author2 Rodrigo, Luis
Viñas Salas, Joan
Piñol Felis, Carme
Ildefonso, C.
author2_role author
author
author
author
dc.subject.none.fl_str_mv Cancer
Carcinogenesis
Colon
topic Cancer
Carcinogenesis
Colon
description Objective: to examine the effect of fecal absence on experimental colon carcinogenesis in both male and female rats. Material and methods: a total of 138 10-week-old Sprague- Dawley, male and female rats were divided into five groups: A) 20 rats, no treatment; B) 26 rats, colonic defunctionalization; C) 30 rats, 18 weekly doses of dimethylhydrazine (DMH), 21 mg/kg body weight each, from the beginning of the study; D) 20 rats, ethylen-diamine-tetraacetic acid for 18 weeks; and E) 42 rats, same surgical procedure as rats in group B plus DMH injections at the same doses as rats in group C. Animals were sacrificed after 25-27 weeks. Number of tumors, their location, and pathological findings were all compared between groups. Results: no tumors developed in the dimethylhydrazine-free groups. No differences were obtained either in number of tumors or tumors per rat for group C as compared to group E. Fecal absence was associated with smaller-sized tumors (p = 0.007), greater numbers of non-mucinous tumors (p = 0.00009), better differentiation (p = 0.0054), and lesser penetration into the wall (p = 0.015) for group E as compared to group C. In the dimethylhydrazine group, fecal absence altered the number of tumors developing in males as compared to female rats (p = 0.025). Moreover, this fecal absence showed no inhibitory effect on right colonic tumors (p = 0.0065). Conclusions: fecal absence alters the DMH-carcinogenic pattern in the defunctionalized colon when using an experimental model in both male and female rats.
publishDate 2006
dc.date.none.fl_str_mv 2006
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10459.1/49278
url http://hdl.handle.net/10459.1/49278
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a http://scielo.isciii.es/scielo.php?pid=S1130-01082006000900002&script=sci_arttext
Revista Española de Enfermedades Digestivas, 2006, vol. 98, núm. 8, p. 644-649
dc.rights.none.fl_str_mv (c) Arán Ediciones, 2006
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Arán Ediciones, 2006
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Sociedad Española de Patología Digestiva
Arán Ediciones
publisher.none.fl_str_mv Sociedad Española de Patología Digestiva
Arán Ediciones
dc.source.none.fl_str_mv reponame:Repositori Obert UdL
instname:Universitat de Lleida (UdL)
instname_str Universitat de Lleida (UdL)
reponame_str Repositori Obert UdL
collection Repositori Obert UdL
repository.name.fl_str_mv
repository.mail.fl_str_mv
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