Low birth weight and small for gestational age are associated with complications of childhood and adolescence obesity: Systematic review and meta-analysis

In recent decades, the incidence of type 2 diabetes (T2D) has increased dramatically in children and adolescents, posing a real public health problem. Beyond unhealthy diets and sedentary lifestyles, growing evidence suggests that some perinatal factors, such as low birth weight (LBW), are associate...

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Autores: Martin-Calvo, Nerea, Goni, Leticia, Tur, Josep A, Martinez, J. Alfredo
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/23476
Acceso en línea:https://hdl.handle.net/20.500.12105/23476
Access Level:acceso abierto
Palabra clave:insulin resistance
low birth weight
small for gestational age
STOP project
Nacimiento Prematuro
Recién Nacido
Femenino
Lactante
Obesidad Pediátrica
Adolescente
Recién Nacido de Bajo Peso
Humanos
Recién Nacido Pequeño para la Edad Gestacional
Edad Gestacional
Embarazo
Diabetes Mellitus Tipo 2
Peso al Nacer
Niño
Adulto
Child
Diabetes Mellitus, Type 2
Adult
Birth Weight
Humans
Adolescent
Gestational Age
Infant, Small for Gestational Age
Infant
Pediatric Obesity
Pregnancy
Infant, Low Birth Weight
Infant, Newborn
Female
Premature Birth
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network_acronym_str ES
network_name_str España
repository_id_str
spelling Low birth weight and small for gestational age are associated with complications of childhood and adolescence obesity: Systematic review and meta-analysisMartin-Calvo, NereaGoni, LeticiaTur, Josep AMartinez, J. Alfredoinsulin resistancelow birth weightsmall for gestational ageSTOP projectNacimiento PrematuroRecién NacidoFemeninoLactanteObesidad PediátricaAdolescenteRecién Nacido de Bajo PesoHumanosRecién Nacido Pequeño para la Edad GestacionalEdad GestacionalEmbarazoDiabetes Mellitus Tipo 2Peso al NacerNiñoAdultoChildDiabetes Mellitus, Type 2AdultBirth WeightHumansAdolescentGestational AgeInfant, Small for Gestational AgeInfantPediatric ObesityPregnancyInfant, Low Birth WeightInfant, NewbornFemalePremature BirthIn recent decades, the incidence of type 2 diabetes (T2D) has increased dramatically in children and adolescents, posing a real public health problem. Beyond unhealthy diets and sedentary lifestyles, growing evidence suggests that some perinatal factors, such as low birth weight (LBW), are associated with higher risk of T2D in adulthood. In this regard, it remains unclear whether the increased risk is already present in childhood and adolescence. We conducted a systematic review and meta-analysis to clarify the association of LBW or being small for gestational age (SGA) with insulin resistance in childhood and adolescence. The systematic review resulted in 28 individual studies, and those with the same outcome were included within two random-effects meta-analyses. Compared with children or adolescents born with adequate size for gestational age, those SGA had 2.33-fold higher risk of T2D (95% confidence interval [CI]: 1.05-5.17). Furthermore, LBW and being SGA were associated with 0.20 higher mean homeostasis model assessment of insulin resistance (HOMA-IR) values (95% CI: 0.02-0.38). Given the high prevalence of preterm babies, from a population perspective, these results may be of great importance as they point to the existence of a potentially vulnerable subgroup of children and adolescents that could benefit from screening tests and early preventive strategies.Wiley20242024-10-0420222022-01-0120222022-01-01review articlehttp://purl.org/coar/resource_type/c_dcae04bcinfo:eu-repo/semantics/articlehttps://hdl.handle.net/20.500.12105/23476reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/234762026-06-12T12:43:37Z
dc.title.none.fl_str_mv Low birth weight and small for gestational age are associated with complications of childhood and adolescence obesity: Systematic review and meta-analysis
title Low birth weight and small for gestational age are associated with complications of childhood and adolescence obesity: Systematic review and meta-analysis
spellingShingle Low birth weight and small for gestational age are associated with complications of childhood and adolescence obesity: Systematic review and meta-analysis
Martin-Calvo, Nerea
insulin resistance
low birth weight
small for gestational age
STOP project
Nacimiento Prematuro
Recién Nacido
Femenino
Lactante
Obesidad Pediátrica
Adolescente
Recién Nacido de Bajo Peso
Humanos
Recién Nacido Pequeño para la Edad Gestacional
Edad Gestacional
Embarazo
Diabetes Mellitus Tipo 2
Peso al Nacer
Niño
Adulto
Child
Diabetes Mellitus, Type 2
Adult
Birth Weight
Humans
Adolescent
Gestational Age
Infant, Small for Gestational Age
Infant
Pediatric Obesity
Pregnancy
Infant, Low Birth Weight
Infant, Newborn
Female
Premature Birth
title_short Low birth weight and small for gestational age are associated with complications of childhood and adolescence obesity: Systematic review and meta-analysis
title_full Low birth weight and small for gestational age are associated with complications of childhood and adolescence obesity: Systematic review and meta-analysis
title_fullStr Low birth weight and small for gestational age are associated with complications of childhood and adolescence obesity: Systematic review and meta-analysis
title_full_unstemmed Low birth weight and small for gestational age are associated with complications of childhood and adolescence obesity: Systematic review and meta-analysis
title_sort Low birth weight and small for gestational age are associated with complications of childhood and adolescence obesity: Systematic review and meta-analysis
dc.creator.none.fl_str_mv Martin-Calvo, Nerea
Goni, Leticia
Tur, Josep A
Martinez, J. Alfredo
author Martin-Calvo, Nerea
author_facet Martin-Calvo, Nerea
Goni, Leticia
Tur, Josep A
Martinez, J. Alfredo
author_role author
author2 Goni, Leticia
Tur, Josep A
Martinez, J. Alfredo
author2_role author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv insulin resistance
low birth weight
small for gestational age
STOP project
Nacimiento Prematuro
Recién Nacido
Femenino
Lactante
Obesidad Pediátrica
Adolescente
Recién Nacido de Bajo Peso
Humanos
Recién Nacido Pequeño para la Edad Gestacional
Edad Gestacional
Embarazo
Diabetes Mellitus Tipo 2
Peso al Nacer
Niño
Adulto
Child
Diabetes Mellitus, Type 2
Adult
Birth Weight
Humans
Adolescent
Gestational Age
Infant, Small for Gestational Age
Infant
Pediatric Obesity
Pregnancy
Infant, Low Birth Weight
Infant, Newborn
Female
Premature Birth
topic insulin resistance
low birth weight
small for gestational age
STOP project
Nacimiento Prematuro
Recién Nacido
Femenino
Lactante
Obesidad Pediátrica
Adolescente
Recién Nacido de Bajo Peso
Humanos
Recién Nacido Pequeño para la Edad Gestacional
Edad Gestacional
Embarazo
Diabetes Mellitus Tipo 2
Peso al Nacer
Niño
Adulto
Child
Diabetes Mellitus, Type 2
Adult
Birth Weight
Humans
Adolescent
Gestational Age
Infant, Small for Gestational Age
Infant
Pediatric Obesity
Pregnancy
Infant, Low Birth Weight
Infant, Newborn
Female
Premature Birth
description In recent decades, the incidence of type 2 diabetes (T2D) has increased dramatically in children and adolescents, posing a real public health problem. Beyond unhealthy diets and sedentary lifestyles, growing evidence suggests that some perinatal factors, such as low birth weight (LBW), are associated with higher risk of T2D in adulthood. In this regard, it remains unclear whether the increased risk is already present in childhood and adolescence. We conducted a systematic review and meta-analysis to clarify the association of LBW or being small for gestational age (SGA) with insulin resistance in childhood and adolescence. The systematic review resulted in 28 individual studies, and those with the same outcome were included within two random-effects meta-analyses. Compared with children or adolescents born with adequate size for gestational age, those SGA had 2.33-fold higher risk of T2D (95% confidence interval [CI]: 1.05-5.17). Furthermore, LBW and being SGA were associated with 0.20 higher mean homeostasis model assessment of insulin resistance (HOMA-IR) values (95% CI: 0.02-0.38). Given the high prevalence of preterm babies, from a population perspective, these results may be of great importance as they point to the existence of a potentially vulnerable subgroup of children and adolescents that could benefit from screening tests and early preventive strategies.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-01-01
2022
2022-01-01
2024
2024-10-04
dc.type.none.fl_str_mv review article
http://purl.org/coar/resource_type/c_dcae04bc
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.12105/23476
url https://hdl.handle.net/20.500.12105/23476
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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