Gender Differences in Health-Related Quality of Life in Patients with Systolic Heart Failure: Results of the VIDA Multicenter Study

Previous studies have shown that heart failure is associated with worse health-related quality of life (HRQoL). The existence of differences according to gender remains controversial. We studied 1028 consecutive outpatients with heart failure and reduced ejection fraction (HFrEF) from a multicentre...

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Autores: Garay, Alberto, Tapia, Javier, Anguita, Manuel, Formiga Pérez, Francesc, Almenar, Luis, Crespo Leiro, María G., Manzano Espinosa, Luis, Muñiz, Javier, Chaves, José, Frutos, Trinidad De, Moliner, Pedro, Corbella, Xavier, Enjuanes, Cristina, Comín Colet, Josep
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/173412
Acceso en línea:https://hdl.handle.net/2445/173412
Access Level:acceso abierto
Palabra clave:Insuficiència cardíaca
Gènere
Qualitat de vida
Heart failure
Gender
Quality of life
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spelling Gender Differences in Health-Related Quality of Life in Patients with Systolic Heart Failure: Results of the VIDA Multicenter StudyGaray, AlbertoTapia, JavierAnguita, ManuelFormiga Pérez, FrancescAlmenar, LuisCrespo Leiro, María G.Manzano Espinosa, LuisMuñiz, JavierChaves, JoséFrutos, Trinidad DeMoliner, PedroCorbella, XavierEnjuanes, CristinaComín Colet, JosepInsuficiència cardíacaGènereQualitat de vidaHeart failureGenderQuality of lifePrevious studies have shown that heart failure is associated with worse health-related quality of life (HRQoL). The existence of differences according to gender remains controversial. We studied 1028 consecutive outpatients with heart failure and reduced ejection fraction (HFrEF) from a multicentre cross-sectional descriptive study across Spain that assessed HRQoL using two questionnaires (KCCQ, Kansas City Cardiomyopathy Questionnaire; and EQ-5D, EuroQoL 5 dimensions). The primary objective of the study was to describe differences in HRQoL between men and women in global scores and domains of health status of patients and explore gender differences and its interactions with heart failure related factors. In adjusted analysis women had lower scores in KCCQ overall summary scores when compared to men denoting worse HRQoL (54.7 +/- 1.3 vs. 62.7 +/- 0.8,p< 0.0001), and specifically got lower score in domains of symptom frequency, symptoms burden, physical limitation, quality of life and social limitation. No differences were found in domains of symptom stability and self-efficacy. Women also had lower scores on all items of EQ-5D (EQ-5D index 0.58 +/- 0.01 vs. 0.67 +/- 0.01,p< 0.0001). Finally, we analyzed interaction between gender and different clinical determinants regarding the presence of limitations in the 5Q-5D and overall summary score of KCCQ. Interestingly, there was no statistical significance for interaction for any variable. In conclusion, women with HFrEF have worse HRQoL compared to men. These differences do not appear to be mediated by clinical or biological factors classically associated with HRQoL nor with heart failure severity.MDPI2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/173412Articles publicats en revistes (Ciències Clíniques)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/jcm9092825Journal of Clinical Medicine, 2020, vol. 9, num. 9https://doi.org/10.3390/jcm9092825cc by (c) Garay et al., 2020http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1734122026-05-27T06:46:51Z
dc.title.none.fl_str_mv Gender Differences in Health-Related Quality of Life in Patients with Systolic Heart Failure: Results of the VIDA Multicenter Study
title Gender Differences in Health-Related Quality of Life in Patients with Systolic Heart Failure: Results of the VIDA Multicenter Study
spellingShingle Gender Differences in Health-Related Quality of Life in Patients with Systolic Heart Failure: Results of the VIDA Multicenter Study
Garay, Alberto
Insuficiència cardíaca
Gènere
Qualitat de vida
Heart failure
Gender
Quality of life
title_short Gender Differences in Health-Related Quality of Life in Patients with Systolic Heart Failure: Results of the VIDA Multicenter Study
title_full Gender Differences in Health-Related Quality of Life in Patients with Systolic Heart Failure: Results of the VIDA Multicenter Study
title_fullStr Gender Differences in Health-Related Quality of Life in Patients with Systolic Heart Failure: Results of the VIDA Multicenter Study
title_full_unstemmed Gender Differences in Health-Related Quality of Life in Patients with Systolic Heart Failure: Results of the VIDA Multicenter Study
title_sort Gender Differences in Health-Related Quality of Life in Patients with Systolic Heart Failure: Results of the VIDA Multicenter Study
dc.creator.none.fl_str_mv Garay, Alberto
Tapia, Javier
Anguita, Manuel
Formiga Pérez, Francesc
Almenar, Luis
Crespo Leiro, María G.
Manzano Espinosa, Luis
Muñiz, Javier
Chaves, José
Frutos, Trinidad De
Moliner, Pedro
Corbella, Xavier
Enjuanes, Cristina
Comín Colet, Josep
author Garay, Alberto
author_facet Garay, Alberto
Tapia, Javier
Anguita, Manuel
Formiga Pérez, Francesc
Almenar, Luis
Crespo Leiro, María G.
Manzano Espinosa, Luis
Muñiz, Javier
Chaves, José
Frutos, Trinidad De
Moliner, Pedro
Corbella, Xavier
Enjuanes, Cristina
Comín Colet, Josep
author_role author
author2 Tapia, Javier
Anguita, Manuel
Formiga Pérez, Francesc
Almenar, Luis
Crespo Leiro, María G.
Manzano Espinosa, Luis
Muñiz, Javier
Chaves, José
Frutos, Trinidad De
Moliner, Pedro
Corbella, Xavier
Enjuanes, Cristina
Comín Colet, Josep
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Insuficiència cardíaca
Gènere
Qualitat de vida
Heart failure
Gender
Quality of life
topic Insuficiència cardíaca
Gènere
Qualitat de vida
Heart failure
Gender
Quality of life
description Previous studies have shown that heart failure is associated with worse health-related quality of life (HRQoL). The existence of differences according to gender remains controversial. We studied 1028 consecutive outpatients with heart failure and reduced ejection fraction (HFrEF) from a multicentre cross-sectional descriptive study across Spain that assessed HRQoL using two questionnaires (KCCQ, Kansas City Cardiomyopathy Questionnaire; and EQ-5D, EuroQoL 5 dimensions). The primary objective of the study was to describe differences in HRQoL between men and women in global scores and domains of health status of patients and explore gender differences and its interactions with heart failure related factors. In adjusted analysis women had lower scores in KCCQ overall summary scores when compared to men denoting worse HRQoL (54.7 +/- 1.3 vs. 62.7 +/- 0.8,p< 0.0001), and specifically got lower score in domains of symptom frequency, symptoms burden, physical limitation, quality of life and social limitation. No differences were found in domains of symptom stability and self-efficacy. Women also had lower scores on all items of EQ-5D (EQ-5D index 0.58 +/- 0.01 vs. 0.67 +/- 0.01,p< 0.0001). Finally, we analyzed interaction between gender and different clinical determinants regarding the presence of limitations in the 5Q-5D and overall summary score of KCCQ. Interestingly, there was no statistical significance for interaction for any variable. In conclusion, women with HFrEF have worse HRQoL compared to men. These differences do not appear to be mediated by clinical or biological factors classically associated with HRQoL nor with heart failure severity.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/173412
url https://hdl.handle.net/2445/173412
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/jcm9092825
Journal of Clinical Medicine, 2020, vol. 9, num. 9
https://doi.org/10.3390/jcm9092825
dc.rights.none.fl_str_mv cc by (c) Garay et al., 2020
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Garay et al., 2020
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Clíniques)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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