Improving the nutritional evaluation in head neck cancer patients using bioelectrical impedance analysis: Not only the phase angle matters

[Background] Malnutrition and sarcopenia are highly prevalent in patients with head neck cancer (HNC). An accurate early diagnosis is necessary for starting nutritional support, as both are clearly associated with clinical outcomes and mortality. We aimed to evaluate the applicability and accuracy o...

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Autores: Herrera-Martínez, Aura D., Prior-Sánchez, Inmaculada, Fernández-Soto, María L., García Olivares, María, Novo Rodríguez, María, González Pacheco, María, Martínez-Ramírez, María José, Carmona-Llanos, Alba, Jiménez-Sánchez, Andrés, Muñoz-Jiménez, Concepción, Torres-Flores, Fátima, Fernández-Jiménez, Rocío, Boughanem, Hatim, Galindo-Gallardo, María Carmen del, Luengo-Pérez, Luis Miguel, Molina Puerta, María José, García-Almeida, José Manuel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/386652
Acceso en línea:http://hdl.handle.net/10261/386652
https://api.elsevier.com/content/abstract/scopus_id/85207034050
Access Level:acceso abierto
Palabra clave:Sarcopenia
Bioelectrical impedance analysis
Head neck cancer
Malnutrition
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spelling Improving the nutritional evaluation in head neck cancer patients using bioelectrical impedance analysis: Not only the phase angle mattersHerrera-Martínez, Aura D.Prior-Sánchez, InmaculadaFernández-Soto, María L.García Olivares, MaríaNovo Rodríguez, MaríaGonzález Pacheco, MaríaMartínez-Ramírez, María JoséCarmona-Llanos, AlbaJiménez-Sánchez, AndrésMuñoz-Jiménez, ConcepciónTorres-Flores, FátimaFernández-Jiménez, RocíoBoughanem, HatimGalindo-Gallardo, María Carmen delLuengo-Pérez, Luis MiguelMolina Puerta, María JoséGarcía-Almeida, José ManuelSarcopeniaBioelectrical impedance analysisHead neck cancerMalnutrition[Background] Malnutrition and sarcopenia are highly prevalent in patients with head neck cancer (HNC). An accurate early diagnosis is necessary for starting nutritional support, as both are clearly associated with clinical outcomes and mortality. We aimed to evaluate the applicability and accuracy of body composition analysis using electrical bioimpedance vectorial analysis (BIVA) for diagnosing malnutrition and sarcopenia in patients with HNC cancer undergoing systemic treatment with chemotherapy or radiotherapy.[Methods] Cross-sectional, observational study that included 509 HNC patients. A comprehensive nutritional evaluation that included BIVA was performed.[Results] The prevalence of malnutrition was higher in patients that received treatment with chemotherapy (59.2% vs. 40.8%, P < 0.001); increased mortality was observed in malnourished patients (33.3% vs. 20.1%; P < 0.001); ECOG status (1–4) was also worse in malnourished patients (59.2% vs. 22.8% P < 0.001). Body cell mass (BCM) and fat mass were the most significantly associated parameters with malnutrition [OR 0.88 (0.84–0.93) and 0.98 (0.95–1.01), respectively]; BCM and fat free mass index (FFMI) were associated with several aspects including (1) the patient-generated subjective global assessment [OR 0.93 (0.84–0.98) and 0.86 (0.76–0.97), respectively], (2) the presence of sarcopenia [OR 0.81 (0.76–0.87) and 0.78 (0.66–0.92), respectively]. A BCM index (BCMI) < 7.8 in combination with other parameters including FFMI and BCM accurately predicted patients with malnutrition [accuracy 95% CI: 0.803 (0.763–0.839); kappa index: 0.486; AUC: 0.618 (P < 0.01)]. A BCMI cutoff of 7.6 was enough for identifying males with malnutrition (P < 0.001), while it should be combined with other parameters in females.[Conclusions] Body composition parameters determined by BIVA accurately identify patients with HNC and malnutrition. Phase angle, but other parameters including BCMI, FFMI and BCM provide significant information about nutritional status in patients with HNC.This work was funded by FRESENEIUS KABI® and Project PI23/01554 funded by Instituto de Salud Carlos III (ISCIII) and co-funded by the European Union, JR19/00050, ISCIII.Peer reviewedJohn Wiley & SonsInstituto de Salud Carlos IIIEuropean CommissionHerrera-Martínez, Aura D. [0000-0003-1437-9878]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202520252024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/386652https://api.elsevier.com/content/abstract/scopus_id/85207034050reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésThe underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.1002/jcsm.13577https://doi.org/10.1002/jcsm.13577Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3866522026-05-22T06:33:51Z
dc.title.none.fl_str_mv Improving the nutritional evaluation in head neck cancer patients using bioelectrical impedance analysis: Not only the phase angle matters
title Improving the nutritional evaluation in head neck cancer patients using bioelectrical impedance analysis: Not only the phase angle matters
spellingShingle Improving the nutritional evaluation in head neck cancer patients using bioelectrical impedance analysis: Not only the phase angle matters
Herrera-Martínez, Aura D.
Sarcopenia
Bioelectrical impedance analysis
Head neck cancer
Malnutrition
title_short Improving the nutritional evaluation in head neck cancer patients using bioelectrical impedance analysis: Not only the phase angle matters
title_full Improving the nutritional evaluation in head neck cancer patients using bioelectrical impedance analysis: Not only the phase angle matters
title_fullStr Improving the nutritional evaluation in head neck cancer patients using bioelectrical impedance analysis: Not only the phase angle matters
title_full_unstemmed Improving the nutritional evaluation in head neck cancer patients using bioelectrical impedance analysis: Not only the phase angle matters
title_sort Improving the nutritional evaluation in head neck cancer patients using bioelectrical impedance analysis: Not only the phase angle matters
dc.creator.none.fl_str_mv Herrera-Martínez, Aura D.
Prior-Sánchez, Inmaculada
Fernández-Soto, María L.
García Olivares, María
Novo Rodríguez, María
González Pacheco, María
Martínez-Ramírez, María José
Carmona-Llanos, Alba
Jiménez-Sánchez, Andrés
Muñoz-Jiménez, Concepción
Torres-Flores, Fátima
Fernández-Jiménez, Rocío
Boughanem, Hatim
Galindo-Gallardo, María Carmen del
Luengo-Pérez, Luis Miguel
Molina Puerta, María José
García-Almeida, José Manuel
author Herrera-Martínez, Aura D.
author_facet Herrera-Martínez, Aura D.
Prior-Sánchez, Inmaculada
Fernández-Soto, María L.
García Olivares, María
Novo Rodríguez, María
González Pacheco, María
Martínez-Ramírez, María José
Carmona-Llanos, Alba
Jiménez-Sánchez, Andrés
Muñoz-Jiménez, Concepción
Torres-Flores, Fátima
Fernández-Jiménez, Rocío
Boughanem, Hatim
Galindo-Gallardo, María Carmen del
Luengo-Pérez, Luis Miguel
Molina Puerta, María José
García-Almeida, José Manuel
author_role author
author2 Prior-Sánchez, Inmaculada
Fernández-Soto, María L.
García Olivares, María
Novo Rodríguez, María
González Pacheco, María
Martínez-Ramírez, María José
Carmona-Llanos, Alba
Jiménez-Sánchez, Andrés
Muñoz-Jiménez, Concepción
Torres-Flores, Fátima
Fernández-Jiménez, Rocío
Boughanem, Hatim
Galindo-Gallardo, María Carmen del
Luengo-Pérez, Luis Miguel
Molina Puerta, María José
García-Almeida, José Manuel
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Instituto de Salud Carlos III
European Commission
Herrera-Martínez, Aura D. [0000-0003-1437-9878]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Sarcopenia
Bioelectrical impedance analysis
Head neck cancer
Malnutrition
topic Sarcopenia
Bioelectrical impedance analysis
Head neck cancer
Malnutrition
description [Background] Malnutrition and sarcopenia are highly prevalent in patients with head neck cancer (HNC). An accurate early diagnosis is necessary for starting nutritional support, as both are clearly associated with clinical outcomes and mortality. We aimed to evaluate the applicability and accuracy of body composition analysis using electrical bioimpedance vectorial analysis (BIVA) for diagnosing malnutrition and sarcopenia in patients with HNC cancer undergoing systemic treatment with chemotherapy or radiotherapy.
publishDate 2024
dc.date.none.fl_str_mv 2024
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/386652
https://api.elsevier.com/content/abstract/scopus_id/85207034050
url http://hdl.handle.net/10261/386652
https://api.elsevier.com/content/abstract/scopus_id/85207034050
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.1002/jcsm.13577
https://doi.org/10.1002/jcsm.13577
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons
publisher.none.fl_str_mv John Wiley & Sons
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812455

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