Intrinsic functional brain connectivity changes following aerobic exercise, computerized cognitive training, and their combination in physically inactive healthy late-middle-aged adults: the Projecte Moviment

Lifestyle interventions have positive neuroprotective effects in aging. However, there are still open questions about how changes in resting-state functional connectivity (rsFC) contribute to cognitive improvements. The Projecte Moviment is a 12-week randomized controlled trial of a multimodal data...

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Detalles Bibliográficos
Autores: Dimitriadis, Stavros, Castells Sánchez, Alba, Roig Coll, Francesca, Dacosta Aguayo, Rosalía, Lamonja Vicente, Noemí, Toran Monserrat, Pere, García Molina, Alberto, Monte Rubio, Gemma, Stillman, Chelsea, Perera Lluna, Alexandre|||0000-0001-6427-851X, Mataro Serrat, Maria
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universitat Politècnica de Catalunya (UPC)
Repositorio:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglés
OAI Identifier:oai:upcommons.upc.edu:2117/396425
Acceso en línea:https://hdl.handle.net/2117/396425
https://dx.doi.org/10.1007/s11357-023-00946-8
Access Level:acceso abierto
Palabra clave:Exercise therapy
Neurosciences
Computational neuroscience
Middle aged persons
Aerobic exercise
Computerized cognitive training
Combined training
MRI
Resting-state functional connectivity
Default mode network
Multiplexity
Exercici terapèutic
Neurociències
Neurociència computacional
Persones de mitjana edat
Àrees temàtiques de la UPC::Informàtica
Àrees temàtiques de la UPC::Ciències de la salut::Medicina::Neurologia
Descripción
Sumario:Lifestyle interventions have positive neuroprotective effects in aging. However, there are still open questions about how changes in resting-state functional connectivity (rsFC) contribute to cognitive improvements. The Projecte Moviment is a 12-week randomized controlled trial of a multimodal data acquisition protocol that investigated the effects of aerobic exercise (AE), computerized cognitive training (CCT), and their combination (COMB). An initial list of 109 participants was recruited from which a total of 82 participants (62% female; age¿=¿58.38¿±¿5.47) finished the intervention with a level of adherence¿>¿80%. Only in the COMB group, we revealed an extended network of 33 connections that involved an increased and decreased rsFC within and between the aDMN/pDMN and a reduced rsFC between the bilateral supplementary motor areas and the right thalamus. No global and especially local rsFC changes due to any intervention mediated the cognitive benefits detected in the AE and COMB groups. Projecte Moviment provides evidence of the clinical relevance of lifestyle interventions and the potential benefits when combining them.

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