Bleomycin in the treatment of keloids and hypertrophic scars by multiple needle punctures

BACKGROUND: The treatment of keloids and hypertrophic scars has been difficult and a recent French study showed that bleomycin has been useful in the treatment of these lesions. OBJECTIVE: To determine the effectiveness and safety of bleomycin in the treatment of hypertrophic scars and keloids when...

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Detalles Bibliográficos
Autores: España-Alonso, A. (Agustín)|||/items/a6e3549c-ab30-4d2e-90a5-fd108573bc9f, Solano, T. (Teresa)|||/items/b4f1b763-4b2c-4565-8f5f-00c1289e83fa, Quintanilla, E. (Emilio)|||/items/6dab7171-dc1a-4531-8f9c-15b60b766307
Tipo de recurso: artículo
Fecha de publicación:2001
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/27346
Acceso en línea:https://hdl.handle.net/10171/27346
Access Level:acceso abierto
Palabra clave:Bleomycin/administration & dosage
Cicatrix, Hypertrophic/drug therapy/pathology
Keloid/drug therapy/pathology
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spelling Bleomycin in the treatment of keloids and hypertrophic scars by multiple needle puncturesEspaña-Alonso, A. (Agustín)|||/items/a6e3549c-ab30-4d2e-90a5-fd108573bc9fSolano, T. (Teresa)|||/items/b4f1b763-4b2c-4565-8f5f-00c1289e83faQuintanilla, E. (Emilio)|||/items/6dab7171-dc1a-4531-8f9c-15b60b766307Bleomycin/administration & dosageCicatrix, Hypertrophic/drug therapy/pathologyKeloid/drug therapy/pathologyBACKGROUND: The treatment of keloids and hypertrophic scars has been difficult and a recent French study showed that bleomycin has been useful in the treatment of these lesions. OBJECTIVE: To determine the effectiveness and safety of bleomycin in the treatment of hypertrophic scars and keloids when this drug is administered through multiple superficial punctures. METHODS: We applied bleomycin to keloids and hypertrophic scars in 13 patients using a multiple-puncture method on the surface of the skin. All patients were given bleomycin at a concentration of 1.5 IU/ml. Clinical response after treatment was classified according to the following scale: complete flattening (100%), highly significant flattening (>90%), or significant flattening (75-90%). RESULTS: The clinical response was very positive in all cases: complete flattening in six cases, highly significant flattening in six cases, and significant flattening in one case. Two patients presented a recurrence as a small nodule 10 and 12 months after the last infiltration. CONCLUSIONS: These clinical findings show that administration of bleomycin in keloids and hypertrophic scars shows promise and needs further investigation.Wiley-BlackwellDadun. Depósito Académico Digital Universidad de Navarra20122012-12-0420012001-01-0120012001-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/27346reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/273462026-06-21T12:47:57Z
dc.title.none.fl_str_mv Bleomycin in the treatment of keloids and hypertrophic scars by multiple needle punctures
title Bleomycin in the treatment of keloids and hypertrophic scars by multiple needle punctures
spellingShingle Bleomycin in the treatment of keloids and hypertrophic scars by multiple needle punctures
España-Alonso, A. (Agustín)|||/items/a6e3549c-ab30-4d2e-90a5-fd108573bc9f
Bleomycin/administration & dosage
Cicatrix, Hypertrophic/drug therapy/pathology
Keloid/drug therapy/pathology
title_short Bleomycin in the treatment of keloids and hypertrophic scars by multiple needle punctures
title_full Bleomycin in the treatment of keloids and hypertrophic scars by multiple needle punctures
title_fullStr Bleomycin in the treatment of keloids and hypertrophic scars by multiple needle punctures
title_full_unstemmed Bleomycin in the treatment of keloids and hypertrophic scars by multiple needle punctures
title_sort Bleomycin in the treatment of keloids and hypertrophic scars by multiple needle punctures
dc.creator.none.fl_str_mv España-Alonso, A. (Agustín)|||/items/a6e3549c-ab30-4d2e-90a5-fd108573bc9f
Solano, T. (Teresa)|||/items/b4f1b763-4b2c-4565-8f5f-00c1289e83fa
Quintanilla, E. (Emilio)|||/items/6dab7171-dc1a-4531-8f9c-15b60b766307
author España-Alonso, A. (Agustín)|||/items/a6e3549c-ab30-4d2e-90a5-fd108573bc9f
author_facet España-Alonso, A. (Agustín)|||/items/a6e3549c-ab30-4d2e-90a5-fd108573bc9f
Solano, T. (Teresa)|||/items/b4f1b763-4b2c-4565-8f5f-00c1289e83fa
Quintanilla, E. (Emilio)|||/items/6dab7171-dc1a-4531-8f9c-15b60b766307
author_role author
author2 Solano, T. (Teresa)|||/items/b4f1b763-4b2c-4565-8f5f-00c1289e83fa
Quintanilla, E. (Emilio)|||/items/6dab7171-dc1a-4531-8f9c-15b60b766307
author2_role author
author
dc.contributor.none.fl_str_mv Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv Bleomycin/administration & dosage
Cicatrix, Hypertrophic/drug therapy/pathology
Keloid/drug therapy/pathology
topic Bleomycin/administration & dosage
Cicatrix, Hypertrophic/drug therapy/pathology
Keloid/drug therapy/pathology
description BACKGROUND: The treatment of keloids and hypertrophic scars has been difficult and a recent French study showed that bleomycin has been useful in the treatment of these lesions. OBJECTIVE: To determine the effectiveness and safety of bleomycin in the treatment of hypertrophic scars and keloids when this drug is administered through multiple superficial punctures. METHODS: We applied bleomycin to keloids and hypertrophic scars in 13 patients using a multiple-puncture method on the surface of the skin. All patients were given bleomycin at a concentration of 1.5 IU/ml. Clinical response after treatment was classified according to the following scale: complete flattening (100%), highly significant flattening (>90%), or significant flattening (75-90%). RESULTS: The clinical response was very positive in all cases: complete flattening in six cases, highly significant flattening in six cases, and significant flattening in one case. Two patients presented a recurrence as a small nodule 10 and 12 months after the last infiltration. CONCLUSIONS: These clinical findings show that administration of bleomycin in keloids and hypertrophic scars shows promise and needs further investigation.
publishDate 2001
dc.date.none.fl_str_mv 2001
2001-01-01
2001
2001-01-01
2012
2012-12-04
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10171/27346
url https://hdl.handle.net/10171/27346
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley-Blackwell
publisher.none.fl_str_mv Wiley-Blackwell
dc.source.none.fl_str_mv reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra
instname:Universidad de Navarra
instname_str Universidad de Navarra
reponame_str Dadun. Depósito Académico Digital de la Universidad de Navarra
collection Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300724

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