Effects and Mechanisms of Cognitive, Aerobic Exercise, and Combined Training on Cognition, Health, and Brain Outcomes in Physically Inactive Older Adults: The Projecte Moviment Protocol

Introduction: Age-related health, brain, and cognitive impairment is a great challenge in current society. Cognitive training, aerobic exercise and their combination have been shown to benefit health, brain, cognition and psychological status in healthy older adults. Inconsistent results across stud...

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Autores: Castells Sánchez, Alba, Roig-Coll, Francesca, Lamonja-Vicente, Noemí, Altés Magret, Marina, Torán Monserrat, Pere, Via i García, Marc, García Molina, Alberto, Tormos, José María, Heras, Antonio, Alzamora, María Teresa, Forés, Rosa, Pera, Guillem, Dacosta-Aguayo, Rosalia, Soriano Raya, Juan José, Cáceres, Cynthia, Montero Alía, Pilar, Montero Alia, Juan José, Jiménez González, María Mercedes, Hernández Pérez, María, Perera Lluna, Alexandre, Grove, George A., Munuera, Josep, Domènech, Sira, Erickson, Kirk I., Mataró Serrat, Maria
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/175688
Acceso en línea:https://hdl.handle.net/2445/175688
Access Level:acceso abierto
Palabra clave:Persones grans
Exercici
Neurociència cognitiva
Older people
Exercise
Cognitive neuroscience
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spelling Effects and Mechanisms of Cognitive, Aerobic Exercise, and Combined Training on Cognition, Health, and Brain Outcomes in Physically Inactive Older Adults: The Projecte Moviment ProtocolCastells Sánchez, AlbaRoig-Coll, FrancescaLamonja-Vicente, NoemíAltés Magret, MarinaTorán Monserrat, PereVia i García, MarcGarcía Molina, AlbertoTormos, José MaríaHeras, AntonioAlzamora, María TeresaForés, RosaPera, GuillemDacosta-Aguayo, RosaliaSoriano Raya, Juan JoséCáceres, CynthiaMontero Alía, PilarMontero Alia, Juan JoséJiménez González, María MercedesHernández Pérez, MaríaPerera Lluna, AlexandreGrove, George A.Munuera, JosepDomènech, SiraErickson, Kirk I.Mataró Serrat, MariaPersones gransExerciciNeurociència cognitivaOlder peopleExerciseCognitive neuroscienceIntroduction: Age-related health, brain, and cognitive impairment is a great challenge in current society. Cognitive training, aerobic exercise and their combination have been shown to benefit health, brain, cognition and psychological status in healthy older adults. Inconsistent results across studies may be related to several variables. We need to better identify cognitive changes, individual variables that may predict the effect of these interventions, and changes in structural and functional brain outcomes as well as physiological molecular correlates that may be mediating these effects. Projecte Moviment is a multi-domain randomized trial examining the effect of these interventions applied 5 days per week for 3 months compared to a passive control group. The aim of this paper is to describe the sample, procedures and planned analyses. Methods: One hundred and forty healthy physically inactive older adults will be randomly assigned to computerized cognitive training (CCT), aerobic exercise (AE), combined training (COMB), or a control group. The intervention consists of a 3 month home-based program 5 days per week in sessions of 45 min. Data from cognitive, physical, and psychological tests, cardiovascular risk factors, structural and functional brain scans, and blood samples will be obtained before and after the intervention. Results: Effects of the interventions on cognitive outcomes will be described in intention-to-treat and per protocol analyses. We will also analyze potential genetic, demographic, brain, and physiological molecular correlates that may predict the effects of intervention, as well as the association between cognitive effects and changes in these variables using the per protocol sample. Discussion: Projecte Moviment is a multi-domain intervention trial based on prior evidence that aims to understand the effects of CCT, AE, and COMB on cognitive and psychological outcomes compared to a passive control group, and to determine related biological correlates and predictors of the intervention effects.Clinical Trial Registration: www.ClinicalTrials.gov, identifier NCT03123900.Frontiers Media2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/175688Articles publicats en revistes (Psicologia Clínica i Psicobiologia)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3389/fnagi.2019.00216Frontiers in Aging Neuroscience, 2019, vol. 11https://doi.org/10.3389/fnagi.2019.00216cc-by (c) Castells Sánchez, Alba et al., 2019http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1756882026-05-27T06:46:51Z
dc.title.none.fl_str_mv Effects and Mechanisms of Cognitive, Aerobic Exercise, and Combined Training on Cognition, Health, and Brain Outcomes in Physically Inactive Older Adults: The Projecte Moviment Protocol
title Effects and Mechanisms of Cognitive, Aerobic Exercise, and Combined Training on Cognition, Health, and Brain Outcomes in Physically Inactive Older Adults: The Projecte Moviment Protocol
spellingShingle Effects and Mechanisms of Cognitive, Aerobic Exercise, and Combined Training on Cognition, Health, and Brain Outcomes in Physically Inactive Older Adults: The Projecte Moviment Protocol
Castells Sánchez, Alba
Persones grans
Exercici
Neurociència cognitiva
Older people
Exercise
Cognitive neuroscience
title_short Effects and Mechanisms of Cognitive, Aerobic Exercise, and Combined Training on Cognition, Health, and Brain Outcomes in Physically Inactive Older Adults: The Projecte Moviment Protocol
title_full Effects and Mechanisms of Cognitive, Aerobic Exercise, and Combined Training on Cognition, Health, and Brain Outcomes in Physically Inactive Older Adults: The Projecte Moviment Protocol
title_fullStr Effects and Mechanisms of Cognitive, Aerobic Exercise, and Combined Training on Cognition, Health, and Brain Outcomes in Physically Inactive Older Adults: The Projecte Moviment Protocol
title_full_unstemmed Effects and Mechanisms of Cognitive, Aerobic Exercise, and Combined Training on Cognition, Health, and Brain Outcomes in Physically Inactive Older Adults: The Projecte Moviment Protocol
title_sort Effects and Mechanisms of Cognitive, Aerobic Exercise, and Combined Training on Cognition, Health, and Brain Outcomes in Physically Inactive Older Adults: The Projecte Moviment Protocol
dc.creator.none.fl_str_mv Castells Sánchez, Alba
Roig-Coll, Francesca
Lamonja-Vicente, Noemí
Altés Magret, Marina
Torán Monserrat, Pere
Via i García, Marc
García Molina, Alberto
Tormos, José María
Heras, Antonio
Alzamora, María Teresa
Forés, Rosa
Pera, Guillem
Dacosta-Aguayo, Rosalia
Soriano Raya, Juan José
Cáceres, Cynthia
Montero Alía, Pilar
Montero Alia, Juan José
Jiménez González, María Mercedes
Hernández Pérez, María
Perera Lluna, Alexandre
Grove, George A.
Munuera, Josep
Domènech, Sira
Erickson, Kirk I.
Mataró Serrat, Maria
author Castells Sánchez, Alba
author_facet Castells Sánchez, Alba
Roig-Coll, Francesca
Lamonja-Vicente, Noemí
Altés Magret, Marina
Torán Monserrat, Pere
Via i García, Marc
García Molina, Alberto
Tormos, José María
Heras, Antonio
Alzamora, María Teresa
Forés, Rosa
Pera, Guillem
Dacosta-Aguayo, Rosalia
Soriano Raya, Juan José
Cáceres, Cynthia
Montero Alía, Pilar
Montero Alia, Juan José
Jiménez González, María Mercedes
Hernández Pérez, María
Perera Lluna, Alexandre
Grove, George A.
Munuera, Josep
Domènech, Sira
Erickson, Kirk I.
Mataró Serrat, Maria
author_role author
author2 Roig-Coll, Francesca
Lamonja-Vicente, Noemí
Altés Magret, Marina
Torán Monserrat, Pere
Via i García, Marc
García Molina, Alberto
Tormos, José María
Heras, Antonio
Alzamora, María Teresa
Forés, Rosa
Pera, Guillem
Dacosta-Aguayo, Rosalia
Soriano Raya, Juan José
Cáceres, Cynthia
Montero Alía, Pilar
Montero Alia, Juan José
Jiménez González, María Mercedes
Hernández Pérez, María
Perera Lluna, Alexandre
Grove, George A.
Munuera, Josep
Domènech, Sira
Erickson, Kirk I.
Mataró Serrat, Maria
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Persones grans
Exercici
Neurociència cognitiva
Older people
Exercise
Cognitive neuroscience
topic Persones grans
Exercici
Neurociència cognitiva
Older people
Exercise
Cognitive neuroscience
description Introduction: Age-related health, brain, and cognitive impairment is a great challenge in current society. Cognitive training, aerobic exercise and their combination have been shown to benefit health, brain, cognition and psychological status in healthy older adults. Inconsistent results across studies may be related to several variables. We need to better identify cognitive changes, individual variables that may predict the effect of these interventions, and changes in structural and functional brain outcomes as well as physiological molecular correlates that may be mediating these effects. Projecte Moviment is a multi-domain randomized trial examining the effect of these interventions applied 5 days per week for 3 months compared to a passive control group. The aim of this paper is to describe the sample, procedures and planned analyses. Methods: One hundred and forty healthy physically inactive older adults will be randomly assigned to computerized cognitive training (CCT), aerobic exercise (AE), combined training (COMB), or a control group. The intervention consists of a 3 month home-based program 5 days per week in sessions of 45 min. Data from cognitive, physical, and psychological tests, cardiovascular risk factors, structural and functional brain scans, and blood samples will be obtained before and after the intervention. Results: Effects of the interventions on cognitive outcomes will be described in intention-to-treat and per protocol analyses. We will also analyze potential genetic, demographic, brain, and physiological molecular correlates that may predict the effects of intervention, as well as the association between cognitive effects and changes in these variables using the per protocol sample. Discussion: Projecte Moviment is a multi-domain intervention trial based on prior evidence that aims to understand the effects of CCT, AE, and COMB on cognitive and psychological outcomes compared to a passive control group, and to determine related biological correlates and predictors of the intervention effects.Clinical Trial Registration: www.ClinicalTrials.gov, identifier NCT03123900.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/175688
url https://hdl.handle.net/2445/175688
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3389/fnagi.2019.00216
Frontiers in Aging Neuroscience, 2019, vol. 11
https://doi.org/10.3389/fnagi.2019.00216
dc.rights.none.fl_str_mv cc-by (c) Castells Sánchez, Alba et al., 2019
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Castells Sánchez, Alba et al., 2019
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv Articles publicats en revistes (Psicologia Clínica i Psicobiologia)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.301603

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