Characterization of COPD admissions during the first COVID-19 outbreak

Purpose: Exacerbations of COPD (ECOPD) are a frequent cause of hospitalization that seemed to ameliorate during the COVID outbreak. We aimed to evaluate the clinical characteristics of COPD-related hospital admissions and mortality in relation to the presence of COVID-19. Patients and Methods: We co...

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Autores: Cosío, Borja G., Shafiek, Hanaa, Toledo-Pons, Nuria, Iglesias, Amanda, Barceló, Margalida, Represas-Represas, Cristina, López-Campos Bodineau, José Luis, Soler-Cataluña, Juan José
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/139230
Acceso en línea:https://hdl.handle.net/11441/139230
Access Level:acceso abierto
Palabra clave:COPD exacerbation
Hospitalization
Inhaled corticosteroids
Mortality
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spelling Characterization of COPD admissions during the first COVID-19 outbreakCosío, Borja G.Shafiek, HanaaToledo-Pons, NuriaIglesias, AmandaBarceló, MargalidaRepresas-Represas, CristinaLópez-Campos Bodineau, José LuisSoler-Cataluña, Juan JoséCOPD exacerbationHospitalizationInhaled corticosteroidsMortalityPurpose: Exacerbations of COPD (ECOPD) are a frequent cause of hospitalization that seemed to ameliorate during the COVID outbreak. We aimed to evaluate the clinical characteristics of COPD-related hospital admissions and mortality in relation to the presence of COVID-19. Patients and Methods: We conducted a case-control study of patients admitted in four teaching hospitals throughout Spain between March 15 and April 30, 2020. Hospital admis- sions of respiratory cause with and without PCR-proven SARS-CoV-2 infection in patients with COPD were evaluated. Baseline and episode-related clinical characteristics were ana- lyzed. Logistic regression analysis was performed to evaluate the risk for mortality. Results: During the study period, 2101 patients were admitted for respiratory worsening, 1200 (57.1%) with COVID-19. A total of 228 (10.8%) were admitted due to COPD worsening, of whom 52 (22.8%) tested positive for COVID-19. COPD patients with COVID-19, when compared to those without COVID-19, were more frequently males with better lung function (FEV1 postbronchodilator 71% vs 46% respectively, p<0.001) and had higher mortality (44.9% vs 13.6% respectively, p<0.001) despite similar age, comorbidities, total days of hospitalization and admission to intensive care unit. COVID-19 and eosinopenia were the strongest risk factors for mortality in the multivariate analysis in the overall COPD population. Inhaled corticosteroid use was not associated to mortality. Conclusion: Hospitalizations for ECOPD without COVID-19 were more frequent than COPD with COVID-19 during the first outbreak, but the latter were associated with higher mortality and low eosinophil counts that warrant further analysis. © 2021 Cosio et al.Dove Medical Press LDTUniversidad de Sevilla. Departamento de MedicinaGlaxoSmithKline (GSK)202220222021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/139230reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésInternational Journal of Chronic Obstructive Pulmonary Disease, 16, 1549-1554.https://pubmed.ncbi.nlm.nih.gov/34113088/info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1392302025-07-17T12:48:51Z
dc.title.none.fl_str_mv Characterization of COPD admissions during the first COVID-19 outbreak
title Characterization of COPD admissions during the first COVID-19 outbreak
spellingShingle Characterization of COPD admissions during the first COVID-19 outbreak
Cosío, Borja G.
COPD exacerbation
Hospitalization
Inhaled corticosteroids
Mortality
title_short Characterization of COPD admissions during the first COVID-19 outbreak
title_full Characterization of COPD admissions during the first COVID-19 outbreak
title_fullStr Characterization of COPD admissions during the first COVID-19 outbreak
title_full_unstemmed Characterization of COPD admissions during the first COVID-19 outbreak
title_sort Characterization of COPD admissions during the first COVID-19 outbreak
dc.creator.none.fl_str_mv Cosío, Borja G.
Shafiek, Hanaa
Toledo-Pons, Nuria
Iglesias, Amanda
Barceló, Margalida
Represas-Represas, Cristina
López-Campos Bodineau, José Luis
Soler-Cataluña, Juan José
author Cosío, Borja G.
author_facet Cosío, Borja G.
Shafiek, Hanaa
Toledo-Pons, Nuria
Iglesias, Amanda
Barceló, Margalida
Represas-Represas, Cristina
López-Campos Bodineau, José Luis
Soler-Cataluña, Juan José
author_role author
author2 Shafiek, Hanaa
Toledo-Pons, Nuria
Iglesias, Amanda
Barceló, Margalida
Represas-Represas, Cristina
López-Campos Bodineau, José Luis
Soler-Cataluña, Juan José
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad de Sevilla. Departamento de Medicina
GlaxoSmithKline (GSK)
dc.subject.none.fl_str_mv COPD exacerbation
Hospitalization
Inhaled corticosteroids
Mortality
topic COPD exacerbation
Hospitalization
Inhaled corticosteroids
Mortality
description Purpose: Exacerbations of COPD (ECOPD) are a frequent cause of hospitalization that seemed to ameliorate during the COVID outbreak. We aimed to evaluate the clinical characteristics of COPD-related hospital admissions and mortality in relation to the presence of COVID-19. Patients and Methods: We conducted a case-control study of patients admitted in four teaching hospitals throughout Spain between March 15 and April 30, 2020. Hospital admis- sions of respiratory cause with and without PCR-proven SARS-CoV-2 infection in patients with COPD were evaluated. Baseline and episode-related clinical characteristics were ana- lyzed. Logistic regression analysis was performed to evaluate the risk for mortality. Results: During the study period, 2101 patients were admitted for respiratory worsening, 1200 (57.1%) with COVID-19. A total of 228 (10.8%) were admitted due to COPD worsening, of whom 52 (22.8%) tested positive for COVID-19. COPD patients with COVID-19, when compared to those without COVID-19, were more frequently males with better lung function (FEV1 postbronchodilator 71% vs 46% respectively, p<0.001) and had higher mortality (44.9% vs 13.6% respectively, p<0.001) despite similar age, comorbidities, total days of hospitalization and admission to intensive care unit. COVID-19 and eosinopenia were the strongest risk factors for mortality in the multivariate analysis in the overall COPD population. Inhaled corticosteroid use was not associated to mortality. Conclusion: Hospitalizations for ECOPD without COVID-19 were more frequent than COPD with COVID-19 during the first outbreak, but the latter were associated with higher mortality and low eosinophil counts that warrant further analysis. © 2021 Cosio et al.
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/139230
url https://hdl.handle.net/11441/139230
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv International Journal of Chronic Obstructive Pulmonary Disease, 16, 1549-1554.
https://pubmed.ncbi.nlm.nih.gov/34113088/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Dove Medical Press LDT
publisher.none.fl_str_mv Dove Medical Press LDT
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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