Relevance of gastrointestinal manifestations in a large Spanish cohort of patients with systemic lupus erythematosus: what do we know?

Tejera Segura, Beatriz; Altabás González, Irene; Rúa-Figueroa, Iñigo; Pérez Veiga, Natalia; Del Campo Pérez, Victor; Olivé-Marqués, Alejandro; Galindo, María; Calvo, Jaime; Ovalles-Bonilla, Juan Gabriel; Fernández-Nebro, Antonio; Menor-Almagro, Raúl; Tomero, Eva; Del Val Del Amo, Natividad; Uriarte Isacelaya, Esther; Martínez-Taboada, Víctor Manuel; Andreu, Jose L; Boteanu, Alina; Narváez, Javier; Movasat, Atusa; Montilla, Carlos; Senabre Gallego, Jose Miguel; Hernández-Cruz, Blanca; Andrés, Mariano; Salgado, Eva; Freire, Mercedes; Machín García, Sergio; Moriano, Clara; Expósito, Lorena; Pérez Velásquez, Clara; Velloso-Feijoo, M L; Cacheda, Ana Paula; Lozano-Rivas, Nuria; Bonilla, Gema; Arévalo, Marta; Jiménez, Inmaculada; Quevedo-Vila, Víctor; Manero-Ruiz, Francisco J; García de la Peña Lefebvre, Paloma; Vázquez-Rodríguez, Tomás Ramón; Ibañez-Rua, Jesús; Cobo-Ibañez, Tatiana; Pego-Reigosa, Jose María

Relevance of gastrointestinal manifestations in a large Spanish cohort of patients with systemic lupus erythematosus: what do we know?

SLE can affect any part of the gastrointestinal (GI) tract. GI symptoms are reported to occur in >50% of SLE patients. To describe the GI manifestations of SLE in the RELESSER (Registry of SLE Patients of the Spanish Society of Rheumatology) cohort and to determine whether these are associated wi...

ver descrição completa

Detalhes bibliográficos
Autores:	Tejera Segura, Beatriz, Altabás González, Irene, Rúa-Figueroa, Iñigo, Pérez Veiga, Natalia, Del Campo Pérez, Victor, Olivé-Marqués, Alejandro, Galindo, María, Calvo, Jaime, Ovalles-Bonilla, Juan Gabriel, Fernández-Nebro, Antonio, Menor-Almagro, Raúl, Tomero, Eva, Del Val Del Amo, Natividad, Uriarte Isacelaya, Esther, Martínez-Taboada, Víctor Manuel, Andreu, Jose L, Boteanu, Alina, Narváez, Javier, Movasat, Atusa, Montilla, Carlos, Senabre Gallego, Jose Miguel, Hernández-Cruz, Blanca, Andrés, Mariano, Salgado, Eva, Freire, Mercedes, Machín García, Sergio, Moriano, Clara, Expósito, Lorena, Pérez Velásquez, Clara, Velloso-Feijoo, M L, Cacheda, Ana Paula, Lozano-Rivas, Nuria, Bonilla, Gema, Arévalo, Marta, Jiménez, Inmaculada, Quevedo-Vila, Víctor, Manero-Ruiz, Francisco J, García de la Peña Lefebvre, Paloma, Vázquez-Rodríguez, Tomás Ramón, Ibañez-Rua, Jesús, Cobo-Ibañez, Tatiana, Pego-Reigosa, Jose María
Formato:	artículo
Fecha de publicación:	2021
País:	España
Recursos:	Universidad de Zaragoza
Repositorio:	Zaguán. Repositorio Digital de la Universidad de Zaragoza
OAI Identifier:	oai:zaguan.unizar.es:110876
Acesso em linha:	http://zaguan.unizar.es/record/110876
Access Level:	acceso abierto

id	ES_ee60e9062c8bcbe8a45f9305449875a3
oai_identifier_str	oai:zaguan.unizar.es:110876
network_acronym_str	ES
network_name_str	España
repository_id_str
spelling	Relevance of gastrointestinal manifestations in a large Spanish cohort of patients with systemic lupus erythematosus: what do we know?Tejera Segura, BeatrizAltabás González, IreneRúa-Figueroa, IñigoPérez Veiga, NataliaDel Campo Pérez, VictorOlivé-Marqués, AlejandroGalindo, MaríaCalvo, JaimeOvalles-Bonilla, Juan GabrielFernández-Nebro, AntonioMenor-Almagro, RaúlTomero, EvaDel Val Del Amo, NatividadUriarte Isacelaya, EstherMartínez-Taboada, Víctor ManuelAndreu, Jose LBoteanu, AlinaNarváez, JavierMovasat, AtusaMontilla, CarlosSenabre Gallego, Jose MiguelHernández-Cruz, BlancaAndrés, MarianoSalgado, EvaFreire, MercedesMachín García, SergioMoriano, ClaraExpósito, LorenaPérez Velásquez, ClaraVelloso-Feijoo, M LCacheda, Ana PaulaLozano-Rivas, NuriaBonilla, GemaArévalo, MartaJiménez, InmaculadaQuevedo-Vila, VíctorManero-Ruiz, Francisco JGarcía de la Peña Lefebvre, PalomaVázquez-Rodríguez, Tomás RamónIbañez-Rua, JesúsCobo-Ibañez, TatianaPego-Reigosa, Jose MaríaSLE can affect any part of the gastrointestinal (GI) tract. GI symptoms are reported to occur in >50% of SLE patients. To describe the GI manifestations of SLE in the RELESSER (Registry of SLE Patients of the Spanish Society of Rheumatology) cohort and to determine whether these are associated with a more severe disease, damage accrual and a worse prognosis. METHODS: We conducted a nationwide, retrospective, multicentre, cross-sectional cohort study of 3658 SLE patients who fulfil =4 ACR-97 criteria. Data on demographics, disease characteristics, activity (SLEDAI-2K or BILAG), damage (SLICC/ACR/DI) and therapies were collected. Demographic and clinical characteristics were compared between lupus patients with and without GI damage to establish whether GI damage is associated with a more severe disease. RESULTS: From 3654 lupus patients, 3.7% developed GI damage. Patients in this group (group 1) were older, they had longer disease duration, and were more likely to have vasculitis, renal disease and serositis than patients without GI damage (group 2). Hospitalizations and mortality were significantly higher in group 1. Patients in group 1 had higher modified SDI (SLICC Damage Index). The presence of oral ulcers reduced the risk of developing damage in 33% of patients. CONCLUSION: Having GI damage is associated with a worse prognosis. Patients on a high dose of glucocorticoids are at higher risk of developing GI damage which reinforces the strategy of minimizing glucocorticoids. Oral ulcers appear to decrease the risk of GI damage. © The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Rheumatology.2021info:eu-repo/semantics/articleapplication/pdfhttp://zaguan.unizar.es/record/110876reponame:Zaguán. Repositorio Digital de la Universidad de Zaragozainstname:Universidad de ZaragozaInglésinfo:eu-repo/semantics/openAccessoai:zaguan.unizar.es:1108762026-05-29T13:59:51Z
dc.title.none.fl_str_mv	Relevance of gastrointestinal manifestations in a large Spanish cohort of patients with systemic lupus erythematosus: what do we know?
title	Relevance of gastrointestinal manifestations in a large Spanish cohort of patients with systemic lupus erythematosus: what do we know?
spellingShingle	Relevance of gastrointestinal manifestations in a large Spanish cohort of patients with systemic lupus erythematosus: what do we know? Tejera Segura, Beatriz
title_short	Relevance of gastrointestinal manifestations in a large Spanish cohort of patients with systemic lupus erythematosus: what do we know?
title_full	Relevance of gastrointestinal manifestations in a large Spanish cohort of patients with systemic lupus erythematosus: what do we know?
title_fullStr	Relevance of gastrointestinal manifestations in a large Spanish cohort of patients with systemic lupus erythematosus: what do we know?
title_full_unstemmed	Relevance of gastrointestinal manifestations in a large Spanish cohort of patients with systemic lupus erythematosus: what do we know?
title_sort	Relevance of gastrointestinal manifestations in a large Spanish cohort of patients with systemic lupus erythematosus: what do we know?
dc.creator.none.fl_str_mv	Tejera Segura, Beatriz Altabás González, Irene Rúa-Figueroa, Iñigo Pérez Veiga, Natalia Del Campo Pérez, Victor Olivé-Marqués, Alejandro Galindo, María Calvo, Jaime Ovalles-Bonilla, Juan Gabriel Fernández-Nebro, Antonio Menor-Almagro, Raúl Tomero, Eva Del Val Del Amo, Natividad Uriarte Isacelaya, Esther Martínez-Taboada, Víctor Manuel Andreu, Jose L Boteanu, Alina Narváez, Javier Movasat, Atusa Montilla, Carlos Senabre Gallego, Jose Miguel Hernández-Cruz, Blanca Andrés, Mariano Salgado, Eva Freire, Mercedes Machín García, Sergio Moriano, Clara Expósito, Lorena Pérez Velásquez, Clara Velloso-Feijoo, M L Cacheda, Ana Paula Lozano-Rivas, Nuria Bonilla, Gema Arévalo, Marta Jiménez, Inmaculada Quevedo-Vila, Víctor Manero-Ruiz, Francisco J García de la Peña Lefebvre, Paloma Vázquez-Rodríguez, Tomás Ramón Ibañez-Rua, Jesús Cobo-Ibañez, Tatiana Pego-Reigosa, Jose María
author	Tejera Segura, Beatriz
author_facet	Tejera Segura, Beatriz Altabás González, Irene Rúa-Figueroa, Iñigo Pérez Veiga, Natalia Del Campo Pérez, Victor Olivé-Marqués, Alejandro Galindo, María Calvo, Jaime Ovalles-Bonilla, Juan Gabriel Fernández-Nebro, Antonio Menor-Almagro, Raúl Tomero, Eva Del Val Del Amo, Natividad Uriarte Isacelaya, Esther Martínez-Taboada, Víctor Manuel Andreu, Jose L Boteanu, Alina Narváez, Javier Movasat, Atusa Montilla, Carlos Senabre Gallego, Jose Miguel Hernández-Cruz, Blanca Andrés, Mariano Salgado, Eva Freire, Mercedes Machín García, Sergio Moriano, Clara Expósito, Lorena Pérez Velásquez, Clara Velloso-Feijoo, M L Cacheda, Ana Paula Lozano-Rivas, Nuria Bonilla, Gema Arévalo, Marta Jiménez, Inmaculada Quevedo-Vila, Víctor Manero-Ruiz, Francisco J García de la Peña Lefebvre, Paloma Vázquez-Rodríguez, Tomás Ramón Ibañez-Rua, Jesús Cobo-Ibañez, Tatiana Pego-Reigosa, Jose María
author_role	author
author2	Altabás González, Irene Rúa-Figueroa, Iñigo Pérez Veiga, Natalia Del Campo Pérez, Victor Olivé-Marqués, Alejandro Galindo, María Calvo, Jaime Ovalles-Bonilla, Juan Gabriel Fernández-Nebro, Antonio Menor-Almagro, Raúl Tomero, Eva Del Val Del Amo, Natividad Uriarte Isacelaya, Esther Martínez-Taboada, Víctor Manuel Andreu, Jose L Boteanu, Alina Narváez, Javier Movasat, Atusa Montilla, Carlos Senabre Gallego, Jose Miguel Hernández-Cruz, Blanca Andrés, Mariano Salgado, Eva Freire, Mercedes Machín García, Sergio Moriano, Clara Expósito, Lorena Pérez Velásquez, Clara Velloso-Feijoo, M L Cacheda, Ana Paula Lozano-Rivas, Nuria Bonilla, Gema Arévalo, Marta Jiménez, Inmaculada Quevedo-Vila, Víctor Manero-Ruiz, Francisco J García de la Peña Lefebvre, Paloma Vázquez-Rodríguez, Tomás Ramón Ibañez-Rua, Jesús Cobo-Ibañez, Tatiana Pego-Reigosa, Jose María
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
description	SLE can affect any part of the gastrointestinal (GI) tract. GI symptoms are reported to occur in >50% of SLE patients. To describe the GI manifestations of SLE in the RELESSER (Registry of SLE Patients of the Spanish Society of Rheumatology) cohort and to determine whether these are associated with a more severe disease, damage accrual and a worse prognosis. METHODS: We conducted a nationwide, retrospective, multicentre, cross-sectional cohort study of 3658 SLE patients who fulfil =4 ACR-97 criteria. Data on demographics, disease characteristics, activity (SLEDAI-2K or BILAG), damage (SLICC/ACR/DI) and therapies were collected. Demographic and clinical characteristics were compared between lupus patients with and without GI damage to establish whether GI damage is associated with a more severe disease. RESULTS: From 3654 lupus patients, 3.7% developed GI damage. Patients in this group (group 1) were older, they had longer disease duration, and were more likely to have vasculitis, renal disease and serositis than patients without GI damage (group 2). Hospitalizations and mortality were significantly higher in group 1. Patients in group 1 had higher modified SDI (SLICC Damage Index). The presence of oral ulcers reduced the risk of developing damage in 33% of patients. CONCLUSION: Having GI damage is associated with a worse prognosis. Patients on a high dose of glucocorticoids are at higher risk of developing GI damage which reinforces the strategy of minimizing glucocorticoids. Oral ulcers appear to decrease the risk of GI damage. © The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Rheumatology.
publishDate	2021
dc.date.none.fl_str_mv	2021
dc.type.none.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	http://zaguan.unizar.es/record/110876
url	http://zaguan.unizar.es/record/110876
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv
publisher.none.fl_str_mv
dc.source.none.fl_str_mv	reponame:Zaguán. Repositorio Digital de la Universidad de Zaragoza instname:Universidad de Zaragoza
instname_str	Universidad de Zaragoza
reponame_str	Zaguán. Repositorio Digital de la Universidad de Zaragoza
collection	Zaguán. Repositorio Digital de la Universidad de Zaragoza
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_	1869423639858774016
score	15.301603

Relevance of gastrointestinal manifestations in a large Spanish cohort of patients with systemic lupus erythematosus: what do we know?

Registos relacionados