Plasma acylcarnitines and gut-derived aromatic amino acids as sex-specific hub metabolites of the human aging metabolome.

Aging biology entails a cell/tissue deregulated metabolism that affects all levels of biological organization. Therefore, the application of "omic" techniques that are closer to phenotype, such as metabolomics, to the study of the aging process should be a turning point in the definition o...

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Autores: Sol, Joaquim, Obis, Elia, Mota-Martorell, Natalia, Pradas, Irene, Galo-Licona, Jose Daniel, Martin-Gari, Meritxell, Fernandez-Bernal, Anna, Ortega-Bravo, Marta, Mayneris-Perxachs, Jordi, Borras, Consuelo, Vina, Jose, de la Fuente, Monica, Mate, Ianire, Biarnes, Carles, Pedraza, Salvador, Vilanova, Joan C, Brugada, Ramon, Ramos, Rafel, Serena, Joaquin, Ramio-Torrenta, Lluis, Pineda, Victor, Daunis-I-Estadella, Pepus, Thio-Henestrosa, Santiago, Barretina, Jordi, Garre-Olmo, Josep, Portero-Otin, Manuel, Fernandez-Real, Jose Manuel, Puig, Josep, Jove, Mariona, Pamplona, Reinald
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:INCLIVA
Repositorio:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
OAI Identifier:oai:incliva.fundanetsuite.com:p17359
Acceso en línea:https://incliva.portalinvestigacion.com/publicaciones/17359
Access Level:acceso abierto
Palabra clave:aging
aromatic amino acids
bioenergetics
liquid chromatography-mass spectrometry
metabolomics
sex/gender perspective
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spelling Plasma acylcarnitines and gut-derived aromatic amino acids as sex-specific hub metabolites of the human aging metabolome.Sol, JoaquimObis, EliaMota-Martorell, NataliaPradas, IreneGalo-Licona, Jose DanielMartin-Gari, MeritxellFernandez-Bernal, AnnaOrtega-Bravo, MartaMayneris-Perxachs, JordiBorras, ConsueloVina, Josede la Fuente, MonicaMate, IanireBiarnes, CarlesPedraza, SalvadorVilanova, Joan CBrugada, RamonRamos, RafelSerena, JoaquinRamio-Torrenta, LluisPineda, VictorDaunis-I-Estadella, PepusThio-Henestrosa, SantiagoBarretina, JordiGarre-Olmo, JosepPortero-Otin, ManuelFernandez-Real, Jose ManuelPuig, JosepJove, MarionaPamplona, Reinaldagingaromatic amino acidsbioenergeticsliquid chromatography-mass spectrometrymetabolomicssex/gender perspectiveAging biology entails a cell/tissue deregulated metabolism that affects all levels of biological organization. Therefore, the application of "omic" techniques that are closer to phenotype, such as metabolomics, to the study of the aging process should be a turning point in the definition of cellular processes involved. The main objective of the present study was to describe the changes in plasma metabolome associated with biological aging and the role of sex in the metabolic regulation during aging. A high-throughput untargeted metabolomic analysis was applied in plasma samples to detect hub metabolites and biomarkers of aging incorporating a sex/gender perspective. A cohort of 1030 healthy human adults (45.9% females, and 54.1% males) from 50 to 98years of age was used. Results were validated using two independent cohorts (1: n=146, 53% females, 30-100years old; 2: n=68, 70% females, 19-107years old). Metabolites related to lipid and aromatic amino acid (AAA) metabolisms arose as the main metabolic pathways affected by age, with a high influence of sex. Globally, we describe changes in bioenergetic pathways that point to a decrease in mitochondrial beta-oxidation and an accumulation of unsaturated fatty acids and acylcarnitines that could be responsible for the increment of oxidative damage and inflammation characteristic of this physiological process. Furthermore, we describe for the first time the importance of gut-derived AAA catabolites in the aging process describing novel biomarkers that could contribute to better understand this physiological process but also age-related diseases. © 2023 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.WILEY2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://incliva.portalinvestigacion.com/publicaciones/17359AGING CELLISSN: 14749718ISSNe: 14749726reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVAinstname:INCLIVAInglésinfo:eu-repo/semantics/openAccessoai:incliva.fundanetsuite.com:p173592026-06-07T16:35:31Z
dc.title.none.fl_str_mv Plasma acylcarnitines and gut-derived aromatic amino acids as sex-specific hub metabolites of the human aging metabolome.
title Plasma acylcarnitines and gut-derived aromatic amino acids as sex-specific hub metabolites of the human aging metabolome.
spellingShingle Plasma acylcarnitines and gut-derived aromatic amino acids as sex-specific hub metabolites of the human aging metabolome.
Sol, Joaquim
aging
aromatic amino acids
bioenergetics
liquid chromatography-mass spectrometry
metabolomics
sex/gender perspective
title_short Plasma acylcarnitines and gut-derived aromatic amino acids as sex-specific hub metabolites of the human aging metabolome.
title_full Plasma acylcarnitines and gut-derived aromatic amino acids as sex-specific hub metabolites of the human aging metabolome.
title_fullStr Plasma acylcarnitines and gut-derived aromatic amino acids as sex-specific hub metabolites of the human aging metabolome.
title_full_unstemmed Plasma acylcarnitines and gut-derived aromatic amino acids as sex-specific hub metabolites of the human aging metabolome.
title_sort Plasma acylcarnitines and gut-derived aromatic amino acids as sex-specific hub metabolites of the human aging metabolome.
dc.creator.none.fl_str_mv Sol, Joaquim
Obis, Elia
Mota-Martorell, Natalia
Pradas, Irene
Galo-Licona, Jose Daniel
Martin-Gari, Meritxell
Fernandez-Bernal, Anna
Ortega-Bravo, Marta
Mayneris-Perxachs, Jordi
Borras, Consuelo
Vina, Jose
de la Fuente, Monica
Mate, Ianire
Biarnes, Carles
Pedraza, Salvador
Vilanova, Joan C
Brugada, Ramon
Ramos, Rafel
Serena, Joaquin
Ramio-Torrenta, Lluis
Pineda, Victor
Daunis-I-Estadella, Pepus
Thio-Henestrosa, Santiago
Barretina, Jordi
Garre-Olmo, Josep
Portero-Otin, Manuel
Fernandez-Real, Jose Manuel
Puig, Josep
Jove, Mariona
Pamplona, Reinald
author Sol, Joaquim
author_facet Sol, Joaquim
Obis, Elia
Mota-Martorell, Natalia
Pradas, Irene
Galo-Licona, Jose Daniel
Martin-Gari, Meritxell
Fernandez-Bernal, Anna
Ortega-Bravo, Marta
Mayneris-Perxachs, Jordi
Borras, Consuelo
Vina, Jose
de la Fuente, Monica
Mate, Ianire
Biarnes, Carles
Pedraza, Salvador
Vilanova, Joan C
Brugada, Ramon
Ramos, Rafel
Serena, Joaquin
Ramio-Torrenta, Lluis
Pineda, Victor
Daunis-I-Estadella, Pepus
Thio-Henestrosa, Santiago
Barretina, Jordi
Garre-Olmo, Josep
Portero-Otin, Manuel
Fernandez-Real, Jose Manuel
Puig, Josep
Jove, Mariona
Pamplona, Reinald
author_role author
author2 Obis, Elia
Mota-Martorell, Natalia
Pradas, Irene
Galo-Licona, Jose Daniel
Martin-Gari, Meritxell
Fernandez-Bernal, Anna
Ortega-Bravo, Marta
Mayneris-Perxachs, Jordi
Borras, Consuelo
Vina, Jose
de la Fuente, Monica
Mate, Ianire
Biarnes, Carles
Pedraza, Salvador
Vilanova, Joan C
Brugada, Ramon
Ramos, Rafel
Serena, Joaquin
Ramio-Torrenta, Lluis
Pineda, Victor
Daunis-I-Estadella, Pepus
Thio-Henestrosa, Santiago
Barretina, Jordi
Garre-Olmo, Josep
Portero-Otin, Manuel
Fernandez-Real, Jose Manuel
Puig, Josep
Jove, Mariona
Pamplona, Reinald
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv aging
aromatic amino acids
bioenergetics
liquid chromatography-mass spectrometry
metabolomics
sex/gender perspective
topic aging
aromatic amino acids
bioenergetics
liquid chromatography-mass spectrometry
metabolomics
sex/gender perspective
description Aging biology entails a cell/tissue deregulated metabolism that affects all levels of biological organization. Therefore, the application of "omic" techniques that are closer to phenotype, such as metabolomics, to the study of the aging process should be a turning point in the definition of cellular processes involved. The main objective of the present study was to describe the changes in plasma metabolome associated with biological aging and the role of sex in the metabolic regulation during aging. A high-throughput untargeted metabolomic analysis was applied in plasma samples to detect hub metabolites and biomarkers of aging incorporating a sex/gender perspective. A cohort of 1030 healthy human adults (45.9% females, and 54.1% males) from 50 to 98years of age was used. Results were validated using two independent cohorts (1: n=146, 53% females, 30-100years old; 2: n=68, 70% females, 19-107years old). Metabolites related to lipid and aromatic amino acid (AAA) metabolisms arose as the main metabolic pathways affected by age, with a high influence of sex. Globally, we describe changes in bioenergetic pathways that point to a decrease in mitochondrial beta-oxidation and an accumulation of unsaturated fatty acids and acylcarnitines that could be responsible for the increment of oxidative damage and inflammation characteristic of this physiological process. Furthermore, we describe for the first time the importance of gut-derived AAA catabolites in the aging process describing novel biomarkers that could contribute to better understand this physiological process but also age-related diseases. © 2023 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://incliva.portalinvestigacion.com/publicaciones/17359
url https://incliva.portalinvestigacion.com/publicaciones/17359
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv WILEY
publisher.none.fl_str_mv WILEY
dc.source.none.fl_str_mv AGING CELL
ISSN: 14749718
ISSNe: 14749726
reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname:INCLIVA
instname_str INCLIVA
reponame_str r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
collection r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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