Nr4a2 Transcription Factor in Hippocampal Synaptic Plasticity, Memory and Cognitive Dysfunction

Long-lasting changes of synaptic efficacy are largely mediated by activity-induced gene transcription and are essential for neuronal plasticity and memory. In this scenario, transcription factors have emerged as pivotal players underlying synaptic plasticity and the modification of neural networks r...

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Autores: Català-Solsona, Judit|||0000-0002-2927-9135, Miñano Molina, Alfredo Jesús|||0000-0002-7761-5682, Rodríguez Álvarez, José|||0000-0001-8582-8082
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:302627
Acceso en línea:https://ddd.uab.cat/record/302627
https://dx.doi.org/urn:doi:10.3389/fnmol.2021.786226
Access Level:acceso abierto
Palabra clave:Nr4a2
Transcription factor
Hippocampus
Synaptic plasticity
Brain
Learning
Memory
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spelling Nr4a2 Transcription Factor in Hippocampal Synaptic Plasticity, Memory and Cognitive DysfunctionA Perspective ReviewCatalà-Solsona, Judit|||0000-0002-2927-9135Miñano Molina, Alfredo Jesús|||0000-0002-7761-5682Rodríguez Álvarez, José|||0000-0001-8582-8082Nr4a2Transcription factorHippocampusSynaptic plasticityBrainLearningMemoryLong-lasting changes of synaptic efficacy are largely mediated by activity-induced gene transcription and are essential for neuronal plasticity and memory. In this scenario, transcription factors have emerged as pivotal players underlying synaptic plasticity and the modification of neural networks required for memory formation and consolidation. Hippocampal synaptic dysfunction is widely accepted to underlie the cognitive decline observed in some neurodegenerative disorders including Alzheimer's disease. Therefore, understanding the molecular pathways regulating gene expression profiles may help to identify new synaptic therapeutic targets. The nuclear receptor 4A subfamily (Nr4a) of transcription factors has been involved in a variety of physiological processes within the hippocampus, ranging from inflammation to neuroprotection. Recent studies have also pointed out a role for the activity-dependent nuclear receptor subfamily 4, group A, member 2 (Nr4a2/Nurr1) in hippocampal synaptic plasticity and cognitive functions, although the underlying molecular mechanisms are still poorly understood. In this review, we highlight the specific effects of Nr4a2 in hippocampal synaptic plasticity and memory formation and we discuss whether the dysregulation of this transcription factor could contribute to hippocampal synaptic dysfunction, altogether suggesting the possibility that Nr4a2 may emerge as a novel synaptic therapeutic target in brain pathologies associated to cognitive dysfunctions. 22021-01-0120212021-01-01Article de revisióhttp://purl.org/coar/resource_type/c_dcae04bcVoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/302627https://dx.doi.org/urn:doi:10.3389/fnmol.2021.786226reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengAgencia Estatal de Investigación https://doi.org/10.13039/501100011033 SAF2017-89271-RAgencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2020-117510RB-I00Ministerio de Sanidad y Consumo CB06/05/0042Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-0749open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3026272026-06-06T12:50:31Z
dc.title.none.fl_str_mv Nr4a2 Transcription Factor in Hippocampal Synaptic Plasticity, Memory and Cognitive Dysfunction
A Perspective Review
title Nr4a2 Transcription Factor in Hippocampal Synaptic Plasticity, Memory and Cognitive Dysfunction
spellingShingle Nr4a2 Transcription Factor in Hippocampal Synaptic Plasticity, Memory and Cognitive Dysfunction
Català-Solsona, Judit|||0000-0002-2927-9135
Nr4a2
Transcription factor
Hippocampus
Synaptic plasticity
Brain
Learning
Memory
title_short Nr4a2 Transcription Factor in Hippocampal Synaptic Plasticity, Memory and Cognitive Dysfunction
title_full Nr4a2 Transcription Factor in Hippocampal Synaptic Plasticity, Memory and Cognitive Dysfunction
title_fullStr Nr4a2 Transcription Factor in Hippocampal Synaptic Plasticity, Memory and Cognitive Dysfunction
title_full_unstemmed Nr4a2 Transcription Factor in Hippocampal Synaptic Plasticity, Memory and Cognitive Dysfunction
title_sort Nr4a2 Transcription Factor in Hippocampal Synaptic Plasticity, Memory and Cognitive Dysfunction
dc.creator.none.fl_str_mv Català-Solsona, Judit|||0000-0002-2927-9135
Miñano Molina, Alfredo Jesús|||0000-0002-7761-5682
Rodríguez Álvarez, José|||0000-0001-8582-8082
author Català-Solsona, Judit|||0000-0002-2927-9135
author_facet Català-Solsona, Judit|||0000-0002-2927-9135
Miñano Molina, Alfredo Jesús|||0000-0002-7761-5682
Rodríguez Álvarez, José|||0000-0001-8582-8082
author_role author
author2 Miñano Molina, Alfredo Jesús|||0000-0002-7761-5682
Rodríguez Álvarez, José|||0000-0001-8582-8082
author2_role author
author
dc.subject.none.fl_str_mv Nr4a2
Transcription factor
Hippocampus
Synaptic plasticity
Brain
Learning
Memory
topic Nr4a2
Transcription factor
Hippocampus
Synaptic plasticity
Brain
Learning
Memory
description Long-lasting changes of synaptic efficacy are largely mediated by activity-induced gene transcription and are essential for neuronal plasticity and memory. In this scenario, transcription factors have emerged as pivotal players underlying synaptic plasticity and the modification of neural networks required for memory formation and consolidation. Hippocampal synaptic dysfunction is widely accepted to underlie the cognitive decline observed in some neurodegenerative disorders including Alzheimer's disease. Therefore, understanding the molecular pathways regulating gene expression profiles may help to identify new synaptic therapeutic targets. The nuclear receptor 4A subfamily (Nr4a) of transcription factors has been involved in a variety of physiological processes within the hippocampus, ranging from inflammation to neuroprotection. Recent studies have also pointed out a role for the activity-dependent nuclear receptor subfamily 4, group A, member 2 (Nr4a2/Nurr1) in hippocampal synaptic plasticity and cognitive functions, although the underlying molecular mechanisms are still poorly understood. In this review, we highlight the specific effects of Nr4a2 in hippocampal synaptic plasticity and memory formation and we discuss whether the dysregulation of this transcription factor could contribute to hippocampal synaptic dysfunction, altogether suggesting the possibility that Nr4a2 may emerge as a novel synaptic therapeutic target in brain pathologies associated to cognitive dysfunctions.
publishDate 2021
dc.date.none.fl_str_mv 2
2021-01-01
2021
2021-01-01
dc.type.none.fl_str_mv Article de revisió
http://purl.org/coar/resource_type/c_dcae04bc
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/302627
https://dx.doi.org/urn:doi:10.3389/fnmol.2021.786226
url https://ddd.uab.cat/record/302627
https://dx.doi.org/urn:doi:10.3389/fnmol.2021.786226
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 SAF2017-89271-R
Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2020-117510RB-I00
Ministerio de Sanidad y Consumo CB06/05/0042
Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-0749
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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