WNT-FRIZZLED-LRP5/6 Signaling Mediates Posterior Fate and Prolifer-ation during Planarian Regeneration

An organizer is defined as a group of cells that secrete extracellular proteins that specify the fate of surrounding cells according to their concentration. Their function during embryogenesis is key in patterning new growing tissues. Although organizers should also participate in adult development...

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Detalles Bibliográficos
Autores: Pascual Carreras, Eudald, Sureda Gómez, Miquel, Barull Mascaró, Ramón, Jordà, Natàlia, Gelabert, María, Coronel-Córdoba, Pablo, Saló i Boix, Emili, Adell i Creixell, Teresa
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/174619
Acceso en línea:https://hdl.handle.net/2445/174619
Access Level:acceso abierto
Palabra clave:Planària (Gènere)
Regeneració (Biologia)
Proteïnes
Planaria (Genus)
Regeneration (Biology)
Proteins
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spelling WNT-FRIZZLED-LRP5/6 Signaling Mediates Posterior Fate and Prolifer-ation during Planarian RegenerationPascual Carreras, EudaldSureda Gómez, MiquelBarull Mascaró, RamónJordà, NatàliaGelabert, MaríaCoronel-Córdoba, PabloSaló i Boix, EmiliAdell i Creixell, TeresaPlanària (Gènere)Regeneració (Biologia)ProteïnesPlanaria (Genus)Regeneration (Biology)ProteinsAn organizer is defined as a group of cells that secrete extracellular proteins that specify the fate of surrounding cells according to their concentration. Their function during embryogenesis is key in patterning new growing tissues. Although organizers should also participate in adult development when new structures are regenerated, their presence in adults has only been identified in a few species with striking regenerative abilities, such as planarians. Planarians provide a unique model to understand the function of adult organizers, since the presence of adult pluripotent stem cells provides them with the ability to regenerate any body part. Previous studies have shown that the differential activation of the WNT/ -catenin signal in each wound is fundamental to establish an anterior or a posterior organizer in the corresponding wound. Here, we identify the receptors that mediate the WNT/ -catenin signal in posterior-facing wounds. We found that Wnt1-Fzd1-LRP5/6 signaling is evolutionarily conserved in executing a WNT/ -catenin signal to specify cell fate and to trigger a proliferative response. Our data allow a better understanding of the mechanism through which organizers signal to a "competent" field of cells and integrate the patterning and growth required during de novo formation of organs and tissues.MDPI2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/174619Articles publicats en revistes (Genètica, Microbiologia i Estadística)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/genes12010101Genes, 2021, vol. 12(1), num. 101https://doi.org/10.3390/genes12010101cc-by (c) Pascual Carreras, Eudald et al., 2021http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1746192026-05-27T06:46:51Z
dc.title.none.fl_str_mv WNT-FRIZZLED-LRP5/6 Signaling Mediates Posterior Fate and Prolifer-ation during Planarian Regeneration
title WNT-FRIZZLED-LRP5/6 Signaling Mediates Posterior Fate and Prolifer-ation during Planarian Regeneration
spellingShingle WNT-FRIZZLED-LRP5/6 Signaling Mediates Posterior Fate and Prolifer-ation during Planarian Regeneration
Pascual Carreras, Eudald
Planària (Gènere)
Regeneració (Biologia)
Proteïnes
Planaria (Genus)
Regeneration (Biology)
Proteins
title_short WNT-FRIZZLED-LRP5/6 Signaling Mediates Posterior Fate and Prolifer-ation during Planarian Regeneration
title_full WNT-FRIZZLED-LRP5/6 Signaling Mediates Posterior Fate and Prolifer-ation during Planarian Regeneration
title_fullStr WNT-FRIZZLED-LRP5/6 Signaling Mediates Posterior Fate and Prolifer-ation during Planarian Regeneration
title_full_unstemmed WNT-FRIZZLED-LRP5/6 Signaling Mediates Posterior Fate and Prolifer-ation during Planarian Regeneration
title_sort WNT-FRIZZLED-LRP5/6 Signaling Mediates Posterior Fate and Prolifer-ation during Planarian Regeneration
dc.creator.none.fl_str_mv Pascual Carreras, Eudald
Sureda Gómez, Miquel
Barull Mascaró, Ramón
Jordà, Natàlia
Gelabert, María
Coronel-Córdoba, Pablo
Saló i Boix, Emili
Adell i Creixell, Teresa
author Pascual Carreras, Eudald
author_facet Pascual Carreras, Eudald
Sureda Gómez, Miquel
Barull Mascaró, Ramón
Jordà, Natàlia
Gelabert, María
Coronel-Córdoba, Pablo
Saló i Boix, Emili
Adell i Creixell, Teresa
author_role author
author2 Sureda Gómez, Miquel
Barull Mascaró, Ramón
Jordà, Natàlia
Gelabert, María
Coronel-Córdoba, Pablo
Saló i Boix, Emili
Adell i Creixell, Teresa
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Planària (Gènere)
Regeneració (Biologia)
Proteïnes
Planaria (Genus)
Regeneration (Biology)
Proteins
topic Planària (Gènere)
Regeneració (Biologia)
Proteïnes
Planaria (Genus)
Regeneration (Biology)
Proteins
description An organizer is defined as a group of cells that secrete extracellular proteins that specify the fate of surrounding cells according to their concentration. Their function during embryogenesis is key in patterning new growing tissues. Although organizers should also participate in adult development when new structures are regenerated, their presence in adults has only been identified in a few species with striking regenerative abilities, such as planarians. Planarians provide a unique model to understand the function of adult organizers, since the presence of adult pluripotent stem cells provides them with the ability to regenerate any body part. Previous studies have shown that the differential activation of the WNT/ -catenin signal in each wound is fundamental to establish an anterior or a posterior organizer in the corresponding wound. Here, we identify the receptors that mediate the WNT/ -catenin signal in posterior-facing wounds. We found that Wnt1-Fzd1-LRP5/6 signaling is evolutionarily conserved in executing a WNT/ -catenin signal to specify cell fate and to trigger a proliferative response. Our data allow a better understanding of the mechanism through which organizers signal to a "competent" field of cells and integrate the patterning and growth required during de novo formation of organs and tissues.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/174619
url https://hdl.handle.net/2445/174619
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/genes12010101
Genes, 2021, vol. 12(1), num. 101
https://doi.org/10.3390/genes12010101
dc.rights.none.fl_str_mv cc-by (c) Pascual Carreras, Eudald et al., 2021
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Pascual Carreras, Eudald et al., 2021
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Genètica, Microbiologia i Estadística)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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