The Implications of ncRNAs in the Development of Human Diseases

The mammalian genome comprehends a small minority of genes that encode for proteins (barely 2% of the total genome in humans) and an immense majority of genes that are transcribed into RNA but not encoded for proteins (ncRNAs). These non-coding genes are intimately related to the expression regulati...

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Detalles Bibliográficos
Autores: López-Jiménez, Elena, Andrés-León, Eduardo
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/247199
Acceso en línea:http://hdl.handle.net/10261/247199
Access Level:acceso abierto
Palabra clave:ncRNAs
lncRNAs
CircRNA
piRNAs
miRNAs in cancer
Cardiovascular and neurode-generative diseases
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spelling The Implications of ncRNAs in the Development of Human DiseasesLópez-Jiménez, ElenaAndrés-León, EduardoncRNAslncRNAsCircRNApiRNAsmiRNAs in cancerCardiovascular and neurode-generative diseasesThe mammalian genome comprehends a small minority of genes that encode for proteins (barely 2% of the total genome in humans) and an immense majority of genes that are transcribed into RNA but not encoded for proteins (ncRNAs). These non-coding genes are intimately related to the expression regulation of protein-coding genes. The ncRNAs subtypes differ in their size, so there are long non-coding genes (lncRNAs) and other smaller ones, like microRNAs (miRNAs) and piwi-interacting RNAs (piRNAs). Due to their important role in the maintenance of cellular functioning, any deregulation of the expression profiles of these ncRNAs can dissemble in the development of different types of diseases. Among them, we can highlight some of high incidence in the population, such as cancer, neurodegenerative, or cardiovascular disorders. In addition, thanks to the enormous advances in the field of medical genomics, these same ncRNAs are starting to be used as possible drugs, approved by the FDA, as an effective treatment for diseasesMultidisciplinary Digital Publishing InstituteConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2021202120212021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bcPublisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/247199reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.3390/ncrna7010017Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2471992026-05-22T06:33:51Z
dc.title.none.fl_str_mv The Implications of ncRNAs in the Development of Human Diseases
title The Implications of ncRNAs in the Development of Human Diseases
spellingShingle The Implications of ncRNAs in the Development of Human Diseases
López-Jiménez, Elena
ncRNAs
lncRNAs
CircRNA
piRNAs
miRNAs in cancer
Cardiovascular and neurode-generative diseases
title_short The Implications of ncRNAs in the Development of Human Diseases
title_full The Implications of ncRNAs in the Development of Human Diseases
title_fullStr The Implications of ncRNAs in the Development of Human Diseases
title_full_unstemmed The Implications of ncRNAs in the Development of Human Diseases
title_sort The Implications of ncRNAs in the Development of Human Diseases
dc.creator.none.fl_str_mv López-Jiménez, Elena
Andrés-León, Eduardo
author López-Jiménez, Elena
author_facet López-Jiménez, Elena
Andrés-León, Eduardo
author_role author
author2 Andrés-León, Eduardo
author2_role author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv ncRNAs
lncRNAs
CircRNA
piRNAs
miRNAs in cancer
Cardiovascular and neurode-generative diseases
topic ncRNAs
lncRNAs
CircRNA
piRNAs
miRNAs in cancer
Cardiovascular and neurode-generative diseases
description The mammalian genome comprehends a small minority of genes that encode for proteins (barely 2% of the total genome in humans) and an immense majority of genes that are transcribed into RNA but not encoded for proteins (ncRNAs). These non-coding genes are intimately related to the expression regulation of protein-coding genes. The ncRNAs subtypes differ in their size, so there are long non-coding genes (lncRNAs) and other smaller ones, like microRNAs (miRNAs) and piwi-interacting RNAs (piRNAs). Due to their important role in the maintenance of cellular functioning, any deregulation of the expression profiles of these ncRNAs can dissemble in the development of different types of diseases. Among them, we can highlight some of high incidence in the population, such as cancer, neurodegenerative, or cardiovascular disorders. In addition, thanks to the enormous advances in the field of medical genomics, these same ncRNAs are starting to be used as possible drugs, approved by the FDA, as an effective treatment for diseases
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_dcae04bc
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/247199
url http://hdl.handle.net/10261/247199
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.3390/ncrna7010017
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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