A novel amphibian herpesvirus (candidate Batravirus ranidallo5) associated with disease in free-ranging Iberian painted frogs (Discoglossus galganoi) in Spain

Amphibians are undergoing a dramatic global decline. This massive biodiversity loss, which is critically impacting public and planetary health, has been attributed to multiple causes including infectious diseases. Of the known pathogens associated with obvious diseases in amphibians, herpesviruses h...

Descripción completa

Detalles Bibliográficos
Autores: Bosch, Jaime, Thumsová, Barbora, Pérez-Martín, Justina, Caballero-Díaz, Carlos, Velarde, Roser, Martínez-Silvestre, Albert, Portmann, Jasmine, Origgi, Francesco C
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/410791
Acceso en línea:http://hdl.handle.net/10261/410791
https://api.elsevier.com/content/abstract/scopus_id/105022598889
Access Level:acceso abierto
Palabra clave:Wildlife
Amphibian
Disease
Frog
Putative Batravirus ranidallo5
id ES_ee47413cebb96d2ca7d3198b7cebed29
oai_identifier_str oai:digital.csic.es:10261/410791
network_acronym_str ES
network_name_str España
repository_id_str
spelling A novel amphibian herpesvirus (candidate Batravirus ranidallo5) associated with disease in free-ranging Iberian painted frogs (Discoglossus galganoi) in SpainBosch, JaimeThumsová, BarboraPérez-Martín, JustinaCaballero-Díaz, CarlosVelarde, RoserMartínez-Silvestre, AlbertPortmann, JasmineOriggi, Francesco CWildlifeAmphibianDiseaseFrogPutative Batravirus ranidallo5Amphibians are undergoing a dramatic global decline. This massive biodiversity loss, which is critically impacting public and planetary health, has been attributed to multiple causes including infectious diseases. Of the known pathogens associated with obvious diseases in amphibians, herpesviruses have recently raised attention secondary to the discovery of two new species, both associated with skin diseases. Here, we provide the detection and characterization of a novel amphibian herpesvirus associated with a proliferative skin disease, closely resembling that previously described in association with Batravirus ranidallo3 (previously Ranid herpesvirus 3-RaHV3) and Bufonid herpesvirus 1 (BfHV1). The novel virus, tentatively named candidate Batravirus ranidallo5 is genetically related, but distinct from the previously described Batraviruses and it is the first amphibian herpesvirus described in Spain. The full-length genome obtained for this novel herpesvirus is approximately 220 kb and it contains the homologues of herpesvirus hallmark genes, which allows us to propose its unambiguous classification as a herpesvirus. Interestingly, a number of predicted ORFs showed to match closer to fish Alloherpesviruses homologues than Batraviruses. The discovery within a limited time span of three distinct herpesviruses, all associated with obvious skin diseases in Europe is alarming and may have significant implication for amphibian conservation.BT was supported by ‘Doctorados Industriales de la Comunidad de Madrid’ (Ref. IND2020/AMB-17438).Peer reviewedSpringer NatureComunidad de MadridBosch, Jaime [0000-0002-0099-7934]Thumsová, Barbora [0000-0003-2856-2331]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202520252025info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/410791https://api.elsevier.com/content/abstract/scopus_id/105022598889reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésThe underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.1038/s41598-025-25189-9https://doi.org/10.1038/s41598-025-25189-9Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/4107912026-05-22T06:33:51Z
dc.title.none.fl_str_mv A novel amphibian herpesvirus (candidate Batravirus ranidallo5) associated with disease in free-ranging Iberian painted frogs (Discoglossus galganoi) in Spain
title A novel amphibian herpesvirus (candidate Batravirus ranidallo5) associated with disease in free-ranging Iberian painted frogs (Discoglossus galganoi) in Spain
spellingShingle A novel amphibian herpesvirus (candidate Batravirus ranidallo5) associated with disease in free-ranging Iberian painted frogs (Discoglossus galganoi) in Spain
Bosch, Jaime
Wildlife
Amphibian
Disease
Frog
Putative Batravirus ranidallo5
title_short A novel amphibian herpesvirus (candidate Batravirus ranidallo5) associated with disease in free-ranging Iberian painted frogs (Discoglossus galganoi) in Spain
title_full A novel amphibian herpesvirus (candidate Batravirus ranidallo5) associated with disease in free-ranging Iberian painted frogs (Discoglossus galganoi) in Spain
title_fullStr A novel amphibian herpesvirus (candidate Batravirus ranidallo5) associated with disease in free-ranging Iberian painted frogs (Discoglossus galganoi) in Spain
title_full_unstemmed A novel amphibian herpesvirus (candidate Batravirus ranidallo5) associated with disease in free-ranging Iberian painted frogs (Discoglossus galganoi) in Spain
title_sort A novel amphibian herpesvirus (candidate Batravirus ranidallo5) associated with disease in free-ranging Iberian painted frogs (Discoglossus galganoi) in Spain
dc.creator.none.fl_str_mv Bosch, Jaime
Thumsová, Barbora
Pérez-Martín, Justina
Caballero-Díaz, Carlos
Velarde, Roser
Martínez-Silvestre, Albert
Portmann, Jasmine
Origgi, Francesco C
author Bosch, Jaime
author_facet Bosch, Jaime
Thumsová, Barbora
Pérez-Martín, Justina
Caballero-Díaz, Carlos
Velarde, Roser
Martínez-Silvestre, Albert
Portmann, Jasmine
Origgi, Francesco C
author_role author
author2 Thumsová, Barbora
Pérez-Martín, Justina
Caballero-Díaz, Carlos
Velarde, Roser
Martínez-Silvestre, Albert
Portmann, Jasmine
Origgi, Francesco C
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Comunidad de Madrid
Bosch, Jaime [0000-0002-0099-7934]
Thumsová, Barbora [0000-0003-2856-2331]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Wildlife
Amphibian
Disease
Frog
Putative Batravirus ranidallo5
topic Wildlife
Amphibian
Disease
Frog
Putative Batravirus ranidallo5
description Amphibians are undergoing a dramatic global decline. This massive biodiversity loss, which is critically impacting public and planetary health, has been attributed to multiple causes including infectious diseases. Of the known pathogens associated with obvious diseases in amphibians, herpesviruses have recently raised attention secondary to the discovery of two new species, both associated with skin diseases. Here, we provide the detection and characterization of a novel amphibian herpesvirus associated with a proliferative skin disease, closely resembling that previously described in association with Batravirus ranidallo3 (previously Ranid herpesvirus 3-RaHV3) and Bufonid herpesvirus 1 (BfHV1). The novel virus, tentatively named candidate Batravirus ranidallo5 is genetically related, but distinct from the previously described Batraviruses and it is the first amphibian herpesvirus described in Spain. The full-length genome obtained for this novel herpesvirus is approximately 220 kb and it contains the homologues of herpesvirus hallmark genes, which allows us to propose its unambiguous classification as a herpesvirus. Interestingly, a number of predicted ORFs showed to match closer to fish Alloherpesviruses homologues than Batraviruses. The discovery within a limited time span of three distinct herpesviruses, all associated with obvious skin diseases in Europe is alarming and may have significant implication for amphibian conservation.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/410791
https://api.elsevier.com/content/abstract/scopus_id/105022598889
url http://hdl.handle.net/10261/410791
https://api.elsevier.com/content/abstract/scopus_id/105022598889
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.1038/s41598-025-25189-9
https://doi.org/10.1038/s41598-025-25189-9
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869423630583070720
score 15.811543

Similares en LA Referencia