Degradation of the anticancer drug erlotinib during water chlorination: Non-targeted approach for the identification of transformation products

Erlotinib is a highly potent tyrosine kinase inhibitor used in the treatment of the most common type of lung cancer. Due to its recent introduction, very scarce information is available on its occurrence, environmental fate and toxicological effects on aquatic organisms. During chlorination processe...

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Autores: Negreira, Noelia, Regueiro, Jorge, López de Alda, Miren, Barceló i Cullerés, Damià
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10256/12574
Acceso en línea:http://hdl.handle.net/10256/12574
Access Level:acceso embargado
Palabra clave:Aigua -- Contaminació
Water -- Pollution
Contaminants emergents en l'aigua
Emerging contaminants in water
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spelling Degradation of the anticancer drug erlotinib during water chlorination: Non-targeted approach for the identification of transformation productsNegreira, NoeliaRegueiro, JorgeLópez de Alda, MirenBarceló i Cullerés, DamiàAigua -- ContaminacióWater -- PollutionContaminants emergents en l'aiguaEmerging contaminants in waterErlotinib is a highly potent tyrosine kinase inhibitor used in the treatment of the most common type of lung cancer. Due to its recent introduction, very scarce information is available on its occurrence, environmental fate and toxicological effects on aquatic organisms. During chlorination processes normally carried out in wastewater treatment plants and in the pretreatment of hospital effluents, chlorinated transformation products can be formed with an enhanced toxicity relative to the parent compound.Thus, the reactivity of the cytostatic drug erlotinib in free chlorine-containing water was investigated for the first time in the present work. A non-targeted screening approach based on the use of differential profiling tools was applied in order to reveal its potential transformation products. Structural elucidation of the detected transformation products was performed by ultra-performance liquid chromatography coupled to high-resolution hybrid quadrupole-Orbitrap tandem mass spectrometry. The proposed approach allowed detecting a total of nineteen transformation products, being eighteen of them described for the first time in this work, which demonstrates its potential in environmental analysis. Among them, six compounds presented chlorine atoms in their structures, which may be of major concern. Other transformation products involved hydroxylation and oxidation reactions. Time-course profiles of erlotinib and its transformation products were followed in real wastewater samples under conditions that simulate wastewater disinfection. Although the structures of these transformation products could not be positively confirmed due to lack of standards, their chemical formulas and product ions can be added to databases, which will allow their screening in future monitoring studiesThis study has been financially supported by the EU through the FP7 projects CYTOTHREAT (265264) and SOLUTIONS (603437), by the Spanish Ministry of Economy and Competitiveness through the project SCARCE (Consolider-Ingenio 2010 CSD2009-00065), and by the Generalitat de Catalunya (Consolidated Research Groups “2014 SGR 418dWater and Soil Quality Unit” and 2014 SGR 291dICRAElsevierMinisterio de Economía y Competitividad (Espanya)infoinfo2015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10256/12574http://hdl.handle.net/10256/12574© Water Research, 2015, vol. 85, p. 103-113Articles publicats (ICRA)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)Inglésinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.watres.2015.08.005info:eu-repo/semantics/altIdentifier/issn/0043-1354info:eu-repo/semantics/altIdentifier/eissn/1879-2448info:eu-repo/grantAgreement/MICINN//CSD2009-00065Tots els drets reservatsinfo:eu-repo/semantics/embargoedAccessoai:recercat.cat:10256/125742026-05-29T05:05:01Z
dc.title.none.fl_str_mv Degradation of the anticancer drug erlotinib during water chlorination: Non-targeted approach for the identification of transformation products
title Degradation of the anticancer drug erlotinib during water chlorination: Non-targeted approach for the identification of transformation products
spellingShingle Degradation of the anticancer drug erlotinib during water chlorination: Non-targeted approach for the identification of transformation products
Negreira, Noelia
Aigua -- Contaminació
Water -- Pollution
Contaminants emergents en l'aigua
Emerging contaminants in water
title_short Degradation of the anticancer drug erlotinib during water chlorination: Non-targeted approach for the identification of transformation products
title_full Degradation of the anticancer drug erlotinib during water chlorination: Non-targeted approach for the identification of transformation products
title_fullStr Degradation of the anticancer drug erlotinib during water chlorination: Non-targeted approach for the identification of transformation products
title_full_unstemmed Degradation of the anticancer drug erlotinib during water chlorination: Non-targeted approach for the identification of transformation products
title_sort Degradation of the anticancer drug erlotinib during water chlorination: Non-targeted approach for the identification of transformation products
dc.creator.none.fl_str_mv Negreira, Noelia
Regueiro, Jorge
López de Alda, Miren
Barceló i Cullerés, Damià
author Negreira, Noelia
author_facet Negreira, Noelia
Regueiro, Jorge
López de Alda, Miren
Barceló i Cullerés, Damià
author_role author
author2 Regueiro, Jorge
López de Alda, Miren
Barceló i Cullerés, Damià
author2_role author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (Espanya)
dc.subject.none.fl_str_mv Aigua -- Contaminació
Water -- Pollution
Contaminants emergents en l'aigua
Emerging contaminants in water
topic Aigua -- Contaminació
Water -- Pollution
Contaminants emergents en l'aigua
Emerging contaminants in water
description Erlotinib is a highly potent tyrosine kinase inhibitor used in the treatment of the most common type of lung cancer. Due to its recent introduction, very scarce information is available on its occurrence, environmental fate and toxicological effects on aquatic organisms. During chlorination processes normally carried out in wastewater treatment plants and in the pretreatment of hospital effluents, chlorinated transformation products can be formed with an enhanced toxicity relative to the parent compound.Thus, the reactivity of the cytostatic drug erlotinib in free chlorine-containing water was investigated for the first time in the present work. A non-targeted screening approach based on the use of differential profiling tools was applied in order to reveal its potential transformation products. Structural elucidation of the detected transformation products was performed by ultra-performance liquid chromatography coupled to high-resolution hybrid quadrupole-Orbitrap tandem mass spectrometry. The proposed approach allowed detecting a total of nineteen transformation products, being eighteen of them described for the first time in this work, which demonstrates its potential in environmental analysis. Among them, six compounds presented chlorine atoms in their structures, which may be of major concern. Other transformation products involved hydroxylation and oxidation reactions. Time-course profiles of erlotinib and its transformation products were followed in real wastewater samples under conditions that simulate wastewater disinfection. Although the structures of these transformation products could not be positively confirmed due to lack of standards, their chemical formulas and product ions can be added to databases, which will allow their screening in future monitoring studies
publishDate 2015
dc.date.none.fl_str_mv 2015
info
info
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10256/12574
http://hdl.handle.net/10256/12574
url http://hdl.handle.net/10256/12574
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.watres.2015.08.005
info:eu-repo/semantics/altIdentifier/issn/0043-1354
info:eu-repo/semantics/altIdentifier/eissn/1879-2448
info:eu-repo/grantAgreement/MICINN//CSD2009-00065
dc.rights.none.fl_str_mv Tots els drets reservats
info:eu-repo/semantics/embargoedAccess
rights_invalid_str_mv Tots els drets reservats
eu_rights_str_mv embargoedAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv © Water Research, 2015, vol. 85, p. 103-113
Articles publicats (ICRA)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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