Outcomes with intensive treatment for acute myeloid leukemia
Since 2017, targeted therapies combined with conventional intensive chemotherapy have started to improve outcomes of patients with acute myeloid leukemia (AML). However, even before these innovations, outcomes with intensive chemotherapy had improved, which has not yet been extensively studied. Thus...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | artículo |
| Fecha de publicación: | 2025 |
| País: | España |
| Recursos: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:322619 |
| Acesso em linha: | https://ddd.uab.cat/record/322619 https://dx.doi.org/urn:doi:10.3324/haematol.2024.285805 |
| Access Level: | acceso abierto |
| Palavra-chave: | Adolescent Adult Aged Aged, 80 and over Antineoplastic Combined Chemotherapy Protocols Europe Female Hematopoietic Stem Cell Transplantation Humans Leukemia, Myeloid, Acute Male Middle Aged Prognosis Treatment Outcome Young Adult |
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Outcomes with intensive treatment for acute myeloid leukemiaan analysis of two decades of data from the HARMONY AllianceSobas, Marta AnnaTurki, Amin|||0000-0003-1347-3360Villaverde Ramiro, Ángela|||0000-0002-7337-7218Hernández-Sánchez, Alberto|||0000-0002-6601-3096Martínez Elicegui, Javier|||0000-0001-5294-6162González, TeresaMelchor, R.A.Abáigar, MaríaTur, L.Dall'Olio, DanieleSträng, E.Tettero, JM.|||0000-0002-0811-0824Castellani, Gastone|||0000-0003-4892-925XBenner, Axel|||0000-0002-7238-6956Döhner, Konstanze|||0000-0002-2261-9862Thiede, Christian|||0000-0003-1241-2048Metzeler, Klaus H.|||0000-0003-3920-7490Haferlach, T.|||0000-0003-0196-2837Damm, FrederikAyala, Rosa|||0000-0002-2699-8353Martínez-López, Joaquín|||0000-0001-7908-0063Mills, Ken|||0000-0002-6362-4481Sierra, Jorge|||0000-0002-7966-0356Lehmann, Sylvain|||0000-0001-6117-562XDella Porta, Matteo Giovanni|||0000-0002-6915-5970Mayer, Jiří|||0000-0003-0567-9887Reinhardt, DirkVilloria Medina, RubénSchulze-Rath, RenateBarbus, MartjeHernández Rivas, Jesús María|||0000-0002-9661-9371Huntly, Brian|||0000-0003-0312-161XOssenkoppele, G.Döhner, Hartmut|||0000-0003-2116-5536Bullinger, Lars|||0000-0002-5890-5510AdolescentAdultAgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsEuropeFemaleHematopoietic Stem Cell TransplantationHumansLeukemia, Myeloid, AcuteMaleMiddle AgedPrognosisTreatment OutcomeYoung AdultSince 2017, targeted therapies combined with conventional intensive chemotherapy have started to improve outcomes of patients with acute myeloid leukemia (AML). However, even before these innovations, outcomes with intensive chemotherapy had improved, which has not yet been extensively studied. Thus, we used a large pan-European multicenter dataset of the HARMONY Alliance to evaluate treatment-time dependent outcomes over two decades. In 5,359 AML patients, we compared the impact of intensive induction therapy on outcome over four consecutive 5-year calendar periods from 1997 to 2016. During that time, the 5-year survival of AML patients improved significantly, also across different genetic risk groups. In particular, the 60-day mortality rate dropped from 13.0% to 4.7% over time. The independent effect of calendar periods on outcome was confirmed in multivariate models. Improvements were documented both for patients <60 and ≥60 years old, and in those treated with and without consolidating allogeneic hematopoietic stem cell transplantation (alloHCT). While survival of AML elderly patients remains poor, patients ≥60 years old overall have a 20% survival benefit at 5 years if they receive an alloHCT. While further outcome improvement in intensively treated AML patients will likely be driven by targeted treatment approaches, this pan-European HARMONY dataset can serve as a multicenter comparator for future studies.Universitat Autònoma de Barcelona. Departament de Medicina 22025-01-0120252025-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/322619https://dx.doi.org/urn:doi:10.3324/haematol.2024.285805reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3226192026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
Outcomes with intensive treatment for acute myeloid leukemia an analysis of two decades of data from the HARMONY Alliance |
| title |
Outcomes with intensive treatment for acute myeloid leukemia |
| spellingShingle |
Outcomes with intensive treatment for acute myeloid leukemia Sobas, Marta Anna Adolescent Adult Aged Aged, 80 and over Antineoplastic Combined Chemotherapy Protocols Europe Female Hematopoietic Stem Cell Transplantation Humans Leukemia, Myeloid, Acute Male Middle Aged Prognosis Treatment Outcome Young Adult |
| title_short |
Outcomes with intensive treatment for acute myeloid leukemia |
| title_full |
Outcomes with intensive treatment for acute myeloid leukemia |
| title_fullStr |
Outcomes with intensive treatment for acute myeloid leukemia |
| title_full_unstemmed |
Outcomes with intensive treatment for acute myeloid leukemia |
| title_sort |
Outcomes with intensive treatment for acute myeloid leukemia |
| dc.creator.none.fl_str_mv |
Sobas, Marta Anna Turki, Amin|||0000-0003-1347-3360 Villaverde Ramiro, Ángela|||0000-0002-7337-7218 Hernández-Sánchez, Alberto|||0000-0002-6601-3096 Martínez Elicegui, Javier|||0000-0001-5294-6162 González, Teresa Melchor, R.A. Abáigar, María Tur, L. Dall'Olio, Daniele Sträng, E. Tettero, JM.|||0000-0002-0811-0824 Castellani, Gastone|||0000-0003-4892-925X Benner, Axel|||0000-0002-7238-6956 Döhner, Konstanze|||0000-0002-2261-9862 Thiede, Christian|||0000-0003-1241-2048 Metzeler, Klaus H.|||0000-0003-3920-7490 Haferlach, T.|||0000-0003-0196-2837 Damm, Frederik Ayala, Rosa|||0000-0002-2699-8353 Martínez-López, Joaquín|||0000-0001-7908-0063 Mills, Ken|||0000-0002-6362-4481 Sierra, Jorge|||0000-0002-7966-0356 Lehmann, Sylvain|||0000-0001-6117-562X Della Porta, Matteo Giovanni|||0000-0002-6915-5970 Mayer, Jiří|||0000-0003-0567-9887 Reinhardt, Dirk Villoria Medina, Rubén Schulze-Rath, Renate Barbus, Martje Hernández Rivas, Jesús María|||0000-0002-9661-9371 Huntly, Brian|||0000-0003-0312-161X Ossenkoppele, G. Döhner, Hartmut|||0000-0003-2116-5536 Bullinger, Lars|||0000-0002-5890-5510 |
| author |
Sobas, Marta Anna |
| author_facet |
Sobas, Marta Anna Turki, Amin|||0000-0003-1347-3360 Villaverde Ramiro, Ángela|||0000-0002-7337-7218 Hernández-Sánchez, Alberto|||0000-0002-6601-3096 Martínez Elicegui, Javier|||0000-0001-5294-6162 González, Teresa Melchor, R.A. Abáigar, María Tur, L. Dall'Olio, Daniele Sträng, E. Tettero, JM.|||0000-0002-0811-0824 Castellani, Gastone|||0000-0003-4892-925X Benner, Axel|||0000-0002-7238-6956 Döhner, Konstanze|||0000-0002-2261-9862 Thiede, Christian|||0000-0003-1241-2048 Metzeler, Klaus H.|||0000-0003-3920-7490 Haferlach, T.|||0000-0003-0196-2837 Damm, Frederik Ayala, Rosa|||0000-0002-2699-8353 Martínez-López, Joaquín|||0000-0001-7908-0063 Mills, Ken|||0000-0002-6362-4481 Sierra, Jorge|||0000-0002-7966-0356 Lehmann, Sylvain|||0000-0001-6117-562X Della Porta, Matteo Giovanni|||0000-0002-6915-5970 Mayer, Jiří|||0000-0003-0567-9887 Reinhardt, Dirk Villoria Medina, Rubén Schulze-Rath, Renate Barbus, Martje Hernández Rivas, Jesús María|||0000-0002-9661-9371 Huntly, Brian|||0000-0003-0312-161X Ossenkoppele, G. Döhner, Hartmut|||0000-0003-2116-5536 Bullinger, Lars|||0000-0002-5890-5510 |
| author_role |
author |
| author2 |
Turki, Amin|||0000-0003-1347-3360 Villaverde Ramiro, Ángela|||0000-0002-7337-7218 Hernández-Sánchez, Alberto|||0000-0002-6601-3096 Martínez Elicegui, Javier|||0000-0001-5294-6162 González, Teresa Melchor, R.A. Abáigar, María Tur, L. Dall'Olio, Daniele Sträng, E. Tettero, JM.|||0000-0002-0811-0824 Castellani, Gastone|||0000-0003-4892-925X Benner, Axel|||0000-0002-7238-6956 Döhner, Konstanze|||0000-0002-2261-9862 Thiede, Christian|||0000-0003-1241-2048 Metzeler, Klaus H.|||0000-0003-3920-7490 Haferlach, T.|||0000-0003-0196-2837 Damm, Frederik Ayala, Rosa|||0000-0002-2699-8353 Martínez-López, Joaquín|||0000-0001-7908-0063 Mills, Ken|||0000-0002-6362-4481 Sierra, Jorge|||0000-0002-7966-0356 Lehmann, Sylvain|||0000-0001-6117-562X Della Porta, Matteo Giovanni|||0000-0002-6915-5970 Mayer, Jiří|||0000-0003-0567-9887 Reinhardt, Dirk Villoria Medina, Rubén Schulze-Rath, Renate Barbus, Martje Hernández Rivas, Jesús María|||0000-0002-9661-9371 Huntly, Brian|||0000-0003-0312-161X Ossenkoppele, G. Döhner, Hartmut|||0000-0003-2116-5536 Bullinger, Lars|||0000-0002-5890-5510 |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universitat Autònoma de Barcelona. Departament de Medicina |
| dc.subject.none.fl_str_mv |
Adolescent Adult Aged Aged, 80 and over Antineoplastic Combined Chemotherapy Protocols Europe Female Hematopoietic Stem Cell Transplantation Humans Leukemia, Myeloid, Acute Male Middle Aged Prognosis Treatment Outcome Young Adult |
| topic |
Adolescent Adult Aged Aged, 80 and over Antineoplastic Combined Chemotherapy Protocols Europe Female Hematopoietic Stem Cell Transplantation Humans Leukemia, Myeloid, Acute Male Middle Aged Prognosis Treatment Outcome Young Adult |
| description |
Since 2017, targeted therapies combined with conventional intensive chemotherapy have started to improve outcomes of patients with acute myeloid leukemia (AML). However, even before these innovations, outcomes with intensive chemotherapy had improved, which has not yet been extensively studied. Thus, we used a large pan-European multicenter dataset of the HARMONY Alliance to evaluate treatment-time dependent outcomes over two decades. In 5,359 AML patients, we compared the impact of intensive induction therapy on outcome over four consecutive 5-year calendar periods from 1997 to 2016. During that time, the 5-year survival of AML patients improved significantly, also across different genetic risk groups. In particular, the 60-day mortality rate dropped from 13.0% to 4.7% over time. The independent effect of calendar periods on outcome was confirmed in multivariate models. Improvements were documented both for patients <60 and ≥60 years old, and in those treated with and without consolidating allogeneic hematopoietic stem cell transplantation (alloHCT). While survival of AML elderly patients remains poor, patients ≥60 years old overall have a 20% survival benefit at 5 years if they receive an alloHCT. While further outcome improvement in intensively treated AML patients will likely be driven by targeted treatment approaches, this pan-European HARMONY dataset can serve as a multicenter comparator for future studies. |
| publishDate |
2025 |
| dc.date.none.fl_str_mv |
2 2025-01-01 2025 2025-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
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article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/322619 https://dx.doi.org/urn:doi:10.3324/haematol.2024.285805 |
| url |
https://ddd.uab.cat/record/322619 https://dx.doi.org/urn:doi:10.3324/haematol.2024.285805 |
| dc.language.none.fl_str_mv |
Inglés eng |
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Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc/4.0/ |
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openAccess |
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application/pdf |
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reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
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Universitat Autònoma de Barcelona |
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Dipòsit Digital de Documents de la UAB |
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Dipòsit Digital de Documents de la UAB |
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