Vaccinated COVID-19 Index Cases Are Less Likely to Transmit SARS-CoV-2 to Their Household Contacts

The aim of this study was to evaluate the impact of index case vaccination on SARS-CoV-2 transmission to household contacts. In our epidemiological cohort study (May 2022-November 2023), we surveyed registered index case vaccination status and test results for contacts (testing on day 0, and on day...

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Detalhes bibliográficos
Autores: Godoy, Pere|||0000-0002-2896-7286, Martínez-Baz, Iván|||0000-0002-3405-2277, Parrón, Ignacio|||0000-0002-4875-0236, García Cenoz, Manuel|||0000-0001-7316-9104, Ferras, Joaquim, Carol, Mònica, Bes, Nuria, Guillaumes, Montserrat|||0009-0008-2827-8836, Godoy, Sofia, Toledo, Diana|||0000-0003-0794-9238, Follia, Núria, Miret, Carme|||0000-0001-6154-3998, Pardos, Jessica, Alsedà, Miquel|||0000-0003-4008-3616, Plans-Rubió, Pedro|||0000-0002-4424-2971, Sanz, Inma, Sala, Maria-Rosa, Caylà, Joan A.|||0000-0003-3891-111X, Mendioroz Peña, Jacobo|||0000-0002-8883-2180, Muñoz-Almagro, Carmen|||0000-0001-5586-404X, Castilla, Jesus|||0000-0002-6396-7265, Domínguez, Ángela|||0000-0003-0219-1907
Tipo de documento: artigo
Data de publicação:2024
País:España
Recursos:Universitat Autònoma de Barcelona
Repositório:Dipòsit Digital de Documents de la UAB
Idioma:inglês
OAI Identifier:oai:ddd.uab.cat:305617
Acesso em linha:https://ddd.uab.cat/record/305617
https://dx.doi.org/urn:doi:10.3390/vaccines12030240
Access Level:Acceso aberto
Palavra-chave:COVID-19
SARS-CoV-2
Household contact
Incidence rate
Secondary attack rate
Vaccine
Descrição
Resumo:The aim of this study was to evaluate the impact of index case vaccination on SARS-CoV-2 transmission to household contacts. In our epidemiological cohort study (May 2022-November 2023), we surveyed registered index case vaccination status and test results for contacts (testing on day 0, and on day 7 for negative contacts) and calculated the secondary attack rate (SAR), i.e., newly infected contacts/susceptible included contacts. The association of the independent variable, index case COVID-19 vaccination (yes/no), with household contact infection was determined using the adjusted odds ratio (aOR) and its 95% confidence interval (CI). We recorded 181 index cases and 314 contacts, of whom 250 agreed to participate; 16 contacts were excluded upon testing positive on day 0. Of the 234 included contacts, 49.1% were women, and the mean (SD) age was 51.9 (19.8) years. The overall SAR of 37.2% (87/234) was lower in the contacts of both vaccinated index cases (34.9% vs. 63.2%; p = 0.014) and index cases with a previous SARS-CoV-2 infection history (27.0% vs. 46.3%; p = 0.002). Index case vaccination showed a protective effect against infection for their household contacts (aOR = 0.21; 95% CI: 0.07, 0.67). The household SAR was high when the Omicron variant circulated. Vaccinated index cases were less likely to transmit SARS-CoV-2 to their contacts.

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