Green Pathways: Enhancing Amine Synthesis Using Deep Eutectic Solvents

Deep eutectic solvents (DESs) have emerged as prominent, environmentally benign substitutes for traditional solvents and catalysts in organic synthesis, notably in the synthesis of amines, pivotal structures in many industrial sectors. Their distinctive physicochemical attributes—including negligibl...

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Detalhes bibliográficos
Autores: Alcántara, Andrés R., Gonzalo Calvo, Gonzalo de
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2025
País:España
Recursos:Universidad de Sevilla (US)
Repositório:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/179171
Acesso em linha:https://hdl.handle.net/11441/179171
https://doi.org/10.3390/catal15060586
Access Level:Acceso aberto
Palavra-chave:Deep eutectic solvents
Amines
Biocatalysis
Metal-based catalysis
Multicomponent reactions
Transaminases
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spelling Green Pathways: Enhancing Amine Synthesis Using Deep Eutectic SolventsAlcántara, Andrés R.Gonzalo Calvo, Gonzalo deDeep eutectic solventsAminesBiocatalysisMetal-based catalysisMulticomponent reactionsTransaminasesDeep eutectic solvents (DESs) have emerged as prominent, environmentally benign substitutes for traditional solvents and catalysts in organic synthesis, notably in the synthesis of amines, pivotal structures in many industrial sectors. Their distinctive physicochemical attributes—including negligible volatility, exceptional thermal stability, and adjustable polarity—render them particularly advantageous for facilitating a broad spectrum of amination reactions. DESs can serve dually as reaction media and as intrinsic catalytic systems, accelerating reaction kinetics without necessitating supplementary catalysts or severe reaction conditions. They are especially efficacious in processes such as reductive amination, transamination, and multicomponent transformations, often affording superior yields and streamlining product isolation. The extensive hydrogen-bonding network intrinsic to DESs is believed to mediate crucial mechanistic steps, frequently obviating the requirement for external additives. Moreover, DESs are recyclable and exhibit compatibility with a diverse array of substrates, encompassing bio-derived and pharmaceutical intermediates.Multidisciplinary Digital Publishing Institute (MDPI)Química OrgánicaMinisterio de Ciencia, Innovación y Universidades (MICIU). EspañaEuropean Union (UE)2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11441/179171https://doi.org/10.3390/catal15060586reponame:idUS. Depósito de Investigación de la Universidad de Sevillainstname:Universidad de Sevilla (US)InglésCatalysts, 15 (6), 586.TED2021-129564B-I00101072731https://doi.org/10.3390/catal15060586info:eu-repo/semantics/openAccessoai:idus.us.es:11441/1791712026-06-17T12:51:07Z
dc.title.none.fl_str_mv Green Pathways: Enhancing Amine Synthesis Using Deep Eutectic Solvents
title Green Pathways: Enhancing Amine Synthesis Using Deep Eutectic Solvents
spellingShingle Green Pathways: Enhancing Amine Synthesis Using Deep Eutectic Solvents
Alcántara, Andrés R.
Deep eutectic solvents
Amines
Biocatalysis
Metal-based catalysis
Multicomponent reactions
Transaminases
title_short Green Pathways: Enhancing Amine Synthesis Using Deep Eutectic Solvents
title_full Green Pathways: Enhancing Amine Synthesis Using Deep Eutectic Solvents
title_fullStr Green Pathways: Enhancing Amine Synthesis Using Deep Eutectic Solvents
title_full_unstemmed Green Pathways: Enhancing Amine Synthesis Using Deep Eutectic Solvents
title_sort Green Pathways: Enhancing Amine Synthesis Using Deep Eutectic Solvents
dc.creator.none.fl_str_mv Alcántara, Andrés R.
Gonzalo Calvo, Gonzalo de
author Alcántara, Andrés R.
author_facet Alcántara, Andrés R.
Gonzalo Calvo, Gonzalo de
author_role author
author2 Gonzalo Calvo, Gonzalo de
author2_role author
dc.contributor.none.fl_str_mv Química Orgánica
Ministerio de Ciencia, Innovación y Universidades (MICIU). España
European Union (UE)
dc.subject.none.fl_str_mv Deep eutectic solvents
Amines
Biocatalysis
Metal-based catalysis
Multicomponent reactions
Transaminases
topic Deep eutectic solvents
Amines
Biocatalysis
Metal-based catalysis
Multicomponent reactions
Transaminases
description Deep eutectic solvents (DESs) have emerged as prominent, environmentally benign substitutes for traditional solvents and catalysts in organic synthesis, notably in the synthesis of amines, pivotal structures in many industrial sectors. Their distinctive physicochemical attributes—including negligible volatility, exceptional thermal stability, and adjustable polarity—render them particularly advantageous for facilitating a broad spectrum of amination reactions. DESs can serve dually as reaction media and as intrinsic catalytic systems, accelerating reaction kinetics without necessitating supplementary catalysts or severe reaction conditions. They are especially efficacious in processes such as reductive amination, transamination, and multicomponent transformations, often affording superior yields and streamlining product isolation. The extensive hydrogen-bonding network intrinsic to DESs is believed to mediate crucial mechanistic steps, frequently obviating the requirement for external additives. Moreover, DESs are recyclable and exhibit compatibility with a diverse array of substrates, encompassing bio-derived and pharmaceutical intermediates.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11441/179171
https://doi.org/10.3390/catal15060586
url https://hdl.handle.net/11441/179171
https://doi.org/10.3390/catal15060586
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Catalysts, 15 (6), 586.
TED2021-129564B-I00
101072731
https://doi.org/10.3390/catal15060586
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
dc.source.none.fl_str_mv reponame:idUS. Depósito de Investigación de la Universidad de Sevilla
instname:Universidad de Sevilla (US)
instname_str Universidad de Sevilla (US)
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
collection idUS. Depósito de Investigación de la Universidad de Sevilla
repository.name.fl_str_mv
repository.mail.fl_str_mv
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