A Voxel-based analysis of FDG-PET in traumatic brain injury: regional metabolism and relationship between the thalamus and cortical areas
[EN] The objective was to study the correlations and the differences in glucose metabolism between the thalamus and cortical structures in a sample of severe traumatic brain injury (TBI) patients with different neurological outcomes. We studied 49 patients who had suffered a severe TBI and 10 health...
| Autores: | , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2011 |
| País: | España |
| Institución: | Universitat Politècnica de València (UPV) |
| Repositorio: | RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia |
| Idioma: | inglés |
| OAI Identifier: | oai:riunet.upv.es:10251/38236 |
| Acceso en línea: | https://riunet.upv.es/handle/10251/38236 |
| Access Level: | acceso abierto |
| Palabra clave: | Cerebral metabolism Consciousness Functional imaging Head injury Image analysis Positron emission tomography FISICA APLICADA |
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A Voxel-based analysis of FDG-PET in traumatic brain injury: regional metabolism and relationship between the thalamus and cortical areasGarcía Panach, JavierLull Noguera, NuriaFerri Domínguez, JoanMartínez, CarlosSopena, PabloRobles Viejo, MontserratChirivella Garrido, JavierNoé Sebastián, EnriqueLull, Juan-José|||0000-0002-4399-950XCerebral metabolismConsciousnessFunctional imagingHead injuryImage analysisPositron emission tomographyFISICA APLICADA[EN] The objective was to study the correlations and the differences in glucose metabolism between the thalamus and cortical structures in a sample of severe traumatic brain injury (TBI) patients with different neurological outcomes. We studied 49 patients who had suffered a severe TBI and 10 healthy control subjects using 18Ffluorodeoxyglucose positron emission tomography (18F-FDG-PET). The patients were divided into three groups: a vegetative or minimally-conscious state (MCS&VS) group (n = 17), which included patients who were in a vegetative or a minimally conscious state; an In-post-traumatic amnesia (In-PTA) group (n = 12), which included patients in PTA; and an Out-PTA group (n = 20), which included patients who had recovered from PTA. SPM5 software was used to determine the metabolic differences between the groups. FDG-PET images were normalized and four regions of interest were generated around the thalamus, precuneus, and the frontal and temporal lobes. The groups were parameterized using Student's t-test. Principal component analysis was used to obtain an intensity-estimated-value per subject to correlate the function between the structures. Differences in glucose metabolism in all structures were related to the neurological outcome, and the most severe patients showed the most severe hypometabolism. We also found a significant correlation between the cortico-thalamocortical metabolism in all groups. Voxel-based analysis suggests a functional correlation between these four areas, and decreased metabolism was associated with less favorable outcomes. Higher levels of activation of the cortico-cortical connections appear to be related to better neurological condition. Differences in the thalamocortical correlations between patients and controls may be related to traumatic dysfunction due to focal or diffuse lesions.A preliminary version of the manuscript presented here has obtained the 2nd award of IV Convocatoria de los Premios de Investigación en Medicina del Colegio de Médicos de Valladolid (IV edition of the Medical Research Award of the Official College of Physicians of Valladolid).Mary Ann LiebertDepartamento de Organización de EmpresasEscuela Técnica Superior de Ingeniería Aeroespacial y Diseño IndustrialRepositorio Institucional de la Universitat Politècnica de València Riunet20112011-09-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://riunet.upv.es/handle/10251/38236reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valénciainstname:Universitat Politècnica de València (UPV)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Reserva de todos los derechoshttp://rightsstatements.org/vocab/InC/1.0/info:eu-repo/semantics/openAccessoai:riunet.upv.es:10251/382362026-06-13T07:49:27Z |
| dc.title.none.fl_str_mv |
A Voxel-based analysis of FDG-PET in traumatic brain injury: regional metabolism and relationship between the thalamus and cortical areas |
| title |
A Voxel-based analysis of FDG-PET in traumatic brain injury: regional metabolism and relationship between the thalamus and cortical areas |
| spellingShingle |
A Voxel-based analysis of FDG-PET in traumatic brain injury: regional metabolism and relationship between the thalamus and cortical areas García Panach, Javier Cerebral metabolism Consciousness Functional imaging Head injury Image analysis Positron emission tomography FISICA APLICADA |
| title_short |
A Voxel-based analysis of FDG-PET in traumatic brain injury: regional metabolism and relationship between the thalamus and cortical areas |
| title_full |
A Voxel-based analysis of FDG-PET in traumatic brain injury: regional metabolism and relationship between the thalamus and cortical areas |
| title_fullStr |
A Voxel-based analysis of FDG-PET in traumatic brain injury: regional metabolism and relationship between the thalamus and cortical areas |
| title_full_unstemmed |
A Voxel-based analysis of FDG-PET in traumatic brain injury: regional metabolism and relationship between the thalamus and cortical areas |
| title_sort |
A Voxel-based analysis of FDG-PET in traumatic brain injury: regional metabolism and relationship between the thalamus and cortical areas |
| dc.creator.none.fl_str_mv |
García Panach, Javier Lull Noguera, Nuria Ferri Domínguez, Joan Martínez, Carlos Sopena, Pablo Robles Viejo, Montserrat Chirivella Garrido, Javier Noé Sebastián, Enrique Lull, Juan-José|||0000-0002-4399-950X |
| author |
García Panach, Javier |
| author_facet |
García Panach, Javier Lull Noguera, Nuria Ferri Domínguez, Joan Martínez, Carlos Sopena, Pablo Robles Viejo, Montserrat Chirivella Garrido, Javier Noé Sebastián, Enrique Lull, Juan-José|||0000-0002-4399-950X |
| author_role |
author |
| author2 |
Lull Noguera, Nuria Ferri Domínguez, Joan Martínez, Carlos Sopena, Pablo Robles Viejo, Montserrat Chirivella Garrido, Javier Noé Sebastián, Enrique Lull, Juan-José|||0000-0002-4399-950X |
| author2_role |
author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Departamento de Organización de Empresas Escuela Técnica Superior de Ingeniería Aeroespacial y Diseño Industrial Repositorio Institucional de la Universitat Politècnica de València Riunet |
| dc.subject.none.fl_str_mv |
Cerebral metabolism Consciousness Functional imaging Head injury Image analysis Positron emission tomography FISICA APLICADA |
| topic |
Cerebral metabolism Consciousness Functional imaging Head injury Image analysis Positron emission tomography FISICA APLICADA |
| description |
[EN] The objective was to study the correlations and the differences in glucose metabolism between the thalamus and cortical structures in a sample of severe traumatic brain injury (TBI) patients with different neurological outcomes. We studied 49 patients who had suffered a severe TBI and 10 healthy control subjects using 18Ffluorodeoxyglucose positron emission tomography (18F-FDG-PET). The patients were divided into three groups: a vegetative or minimally-conscious state (MCS&VS) group (n = 17), which included patients who were in a vegetative or a minimally conscious state; an In-post-traumatic amnesia (In-PTA) group (n = 12), which included patients in PTA; and an Out-PTA group (n = 20), which included patients who had recovered from PTA. SPM5 software was used to determine the metabolic differences between the groups. FDG-PET images were normalized and four regions of interest were generated around the thalamus, precuneus, and the frontal and temporal lobes. The groups were parameterized using Student's t-test. Principal component analysis was used to obtain an intensity-estimated-value per subject to correlate the function between the structures. Differences in glucose metabolism in all structures were related to the neurological outcome, and the most severe patients showed the most severe hypometabolism. We also found a significant correlation between the cortico-thalamocortical metabolism in all groups. Voxel-based analysis suggests a functional correlation between these four areas, and decreased metabolism was associated with less favorable outcomes. Higher levels of activation of the cortico-cortical connections appear to be related to better neurological condition. Differences in the thalamocortical correlations between patients and controls may be related to traumatic dysfunction due to focal or diffuse lesions. |
| publishDate |
2011 |
| dc.date.none.fl_str_mv |
2011 2011-09-01 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://riunet.upv.es/handle/10251/38236 |
| url |
https://riunet.upv.es/handle/10251/38236 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Reserva de todos los derechos http://rightsstatements.org/vocab/InC/1.0/ |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Reserva de todos los derechos http://rightsstatements.org/vocab/InC/1.0/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
Mary Ann Liebert |
| publisher.none.fl_str_mv |
Mary Ann Liebert |
| dc.source.none.fl_str_mv |
reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia instname:Universitat Politècnica de València (UPV) |
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Universitat Politècnica de València (UPV) |
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RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia |
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RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia |
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