Consumption of peanut products improves memory and stress response in healthy adults from the ARISTOTLE study: A 6-month randomized controlled trial

Background: Peanuts are rich in bioactive compounds that may have a positive impact on memory and stress response. Objective: To evaluate the effect of regular consumption of peanut products on cognitive functions and stress response in healthy young adults. Design: A three-arm parallel-group random...

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Autores: Parilli Moser, Isabella, Domínguez López, Inés, Trius-Soler, Marta, Castellví, Magdalena, Bosch Capdevila, Beatriz, Castro-Barquero, Sara, Estruch Riba, Ramon, Hurtado Barroso, Sara, Lamuela Raventós, Rosa Ma.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/183049
Acceso en línea:https://hdl.handle.net/2445/183049
Access Level:acceso abierto
Palabra clave:Polifenols
Cognició
Àcids grassos saturats
Polyphenols
Cognition
Saturated fatty acids
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spelling Consumption of peanut products improves memory and stress response in healthy adults from the ARISTOTLE study: A 6-month randomized controlled trialParilli Moser, IsabellaDomínguez López, InésTrius-Soler, MartaCastellví, MagdalenaBosch Capdevila, BeatrizCastro-Barquero, SaraEstruch Riba, RamonHurtado Barroso, SaraLamuela Raventós, Rosa Ma.PolifenolsCognicióÀcids grassos saturatsPolyphenolsCognitionSaturated fatty acidsBackground: Peanuts are rich in bioactive compounds that may have a positive impact on memory and stress response. Objective: To evaluate the effect of regular consumption of peanut products on cognitive functions and stress response in healthy young adults. Design: A three-arm parallel-group randomized controlled trial was conducted in 63 healthy young adults that consumed 25 g/day of skin roasted peanuts (SRP, n = 21), 32 g/d of peanut butter (PB, n = 23) or 32 g/d of a control butter made from peanut oil (free of phenolic compounds and fiber) (CB, n = 19) for six months. Polyphenol intake, cognitive functions, and anxiety and depression scores were evaluated using validated tests. Fecal short-chain fatty acids (SCFAs) and plasma and fecal fatty acids were assessed by chromatographic methods. Urinary cortisol was quantified by an enzymatic method. Results: Comparing the two interventions with the control, a significant reduction in anxiety scores was observed in the SRP compared to the CB group. After the intervention, consumers of SRP and PB had an improved immediate memory (p = 0.046 and p = 0.011). Lower anxiety scores were associated with SRP and PB (p < 0.001 and p = 0.002, respectively) and lower depression scores with SRP, PB and CB (p = 0.007, p = 0.003 and p = 0.032, respectively). Memory functions and stress response were significantly correlated with polyphenol intake, fecal SCFAs, plasma and fecal very long chain saturated fatty acids (VLCSFAs). Conclusions: Regular peanut and peanut butter consumption may enhance memory function and stress response in a healthy young population. These effects seem to be associated with the intake of peanut polyphenols, increased levels of fecal SCFAs, and unexpectedly, VLCSFAs, which were also present in the control product. Keywords: Cognition; Gut-brain axis; Polyphenols; Resveratrol; Short-chain fatty acids; Very long-chain saturated fatty acids.Elsevier2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/183049Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1016/j.clnu.2021.09.020Clinical Nutrition, 2021, vol. 40, num. 11, p. 5556-5567https://doi.org/10.1016/j.clnu.2021.09.020cc-by (c) Isabella Parilli-Moser, et al., 2021http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1830492026-05-27T06:46:51Z
dc.title.none.fl_str_mv Consumption of peanut products improves memory and stress response in healthy adults from the ARISTOTLE study: A 6-month randomized controlled trial
title Consumption of peanut products improves memory and stress response in healthy adults from the ARISTOTLE study: A 6-month randomized controlled trial
spellingShingle Consumption of peanut products improves memory and stress response in healthy adults from the ARISTOTLE study: A 6-month randomized controlled trial
Parilli Moser, Isabella
Polifenols
Cognició
Àcids grassos saturats
Polyphenols
Cognition
Saturated fatty acids
title_short Consumption of peanut products improves memory and stress response in healthy adults from the ARISTOTLE study: A 6-month randomized controlled trial
title_full Consumption of peanut products improves memory and stress response in healthy adults from the ARISTOTLE study: A 6-month randomized controlled trial
title_fullStr Consumption of peanut products improves memory and stress response in healthy adults from the ARISTOTLE study: A 6-month randomized controlled trial
title_full_unstemmed Consumption of peanut products improves memory and stress response in healthy adults from the ARISTOTLE study: A 6-month randomized controlled trial
title_sort Consumption of peanut products improves memory and stress response in healthy adults from the ARISTOTLE study: A 6-month randomized controlled trial
dc.creator.none.fl_str_mv Parilli Moser, Isabella
Domínguez López, Inés
Trius-Soler, Marta
Castellví, Magdalena
Bosch Capdevila, Beatriz
Castro-Barquero, Sara
Estruch Riba, Ramon
Hurtado Barroso, Sara
Lamuela Raventós, Rosa Ma.
author Parilli Moser, Isabella
author_facet Parilli Moser, Isabella
Domínguez López, Inés
Trius-Soler, Marta
Castellví, Magdalena
Bosch Capdevila, Beatriz
Castro-Barquero, Sara
Estruch Riba, Ramon
Hurtado Barroso, Sara
Lamuela Raventós, Rosa Ma.
author_role author
author2 Domínguez López, Inés
Trius-Soler, Marta
Castellví, Magdalena
Bosch Capdevila, Beatriz
Castro-Barquero, Sara
Estruch Riba, Ramon
Hurtado Barroso, Sara
Lamuela Raventós, Rosa Ma.
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Polifenols
Cognició
Àcids grassos saturats
Polyphenols
Cognition
Saturated fatty acids
topic Polifenols
Cognició
Àcids grassos saturats
Polyphenols
Cognition
Saturated fatty acids
description Background: Peanuts are rich in bioactive compounds that may have a positive impact on memory and stress response. Objective: To evaluate the effect of regular consumption of peanut products on cognitive functions and stress response in healthy young adults. Design: A three-arm parallel-group randomized controlled trial was conducted in 63 healthy young adults that consumed 25 g/day of skin roasted peanuts (SRP, n = 21), 32 g/d of peanut butter (PB, n = 23) or 32 g/d of a control butter made from peanut oil (free of phenolic compounds and fiber) (CB, n = 19) for six months. Polyphenol intake, cognitive functions, and anxiety and depression scores were evaluated using validated tests. Fecal short-chain fatty acids (SCFAs) and plasma and fecal fatty acids were assessed by chromatographic methods. Urinary cortisol was quantified by an enzymatic method. Results: Comparing the two interventions with the control, a significant reduction in anxiety scores was observed in the SRP compared to the CB group. After the intervention, consumers of SRP and PB had an improved immediate memory (p = 0.046 and p = 0.011). Lower anxiety scores were associated with SRP and PB (p < 0.001 and p = 0.002, respectively) and lower depression scores with SRP, PB and CB (p = 0.007, p = 0.003 and p = 0.032, respectively). Memory functions and stress response were significantly correlated with polyphenol intake, fecal SCFAs, plasma and fecal very long chain saturated fatty acids (VLCSFAs). Conclusions: Regular peanut and peanut butter consumption may enhance memory function and stress response in a healthy young population. These effects seem to be associated with the intake of peanut polyphenols, increased levels of fecal SCFAs, and unexpectedly, VLCSFAs, which were also present in the control product. Keywords: Cognition; Gut-brain axis; Polyphenols; Resveratrol; Short-chain fatty acids; Very long-chain saturated fatty acids.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/183049
url https://hdl.handle.net/2445/183049
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1016/j.clnu.2021.09.020
Clinical Nutrition, 2021, vol. 40, num. 11, p. 5556-5567
https://doi.org/10.1016/j.clnu.2021.09.020
dc.rights.none.fl_str_mv cc-by (c) Isabella Parilli-Moser, et al., 2021
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Isabella Parilli-Moser, et al., 2021
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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