First evidence of a pro-inflammatory response to severe infection with influenza virus H1N1

The great majority of infections caused by the pandemic variant of the influenza virus (nvH1N1) are self-limited, but a small percentage of patients develop severe symptoms requiring hospitalization. Bermejo-Martin and colleagues have presented a pilot study describing the differences in the early i...

Descripción completa

Detalles Bibliográficos
Autores: Fernández de Castro, Isabel, Guzman-Fulgencio, Maria, Garcia-Alvarez, Monica, Resino, Salvador
Tipo de recurso: artículo
Fecha de publicación:2010
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/7622
Acceso en línea:http://hdl.handle.net/20.500.12105/7622
Access Level:acceso abierto
Palabra clave:Case-Control Studies
Cytokines
Humans
Inflammation
Influenza A Virus, H1N1 Subtype
Influenza, Human
id ES_ededcb3fcd0a2e9457dfb22f23a772fa
oai_identifier_str oai:repisalud.isciii.es:20.500.12105/7622
network_acronym_str ES
network_name_str España
repository_id_str
spelling First evidence of a pro-inflammatory response to severe infection with influenza virus H1N1Fernández de Castro, IsabelGuzman-Fulgencio, MariaGarcia-Alvarez, MonicaResino, SalvadorCase-Control StudiesCytokinesHumansInflammationInfluenza A Virus, H1N1 SubtypeInfluenza, HumanThe great majority of infections caused by the pandemic variant of the influenza virus (nvH1N1) are self-limited, but a small percentage of patients develop severe symptoms requiring hospitalization. Bermejo-Martin and colleagues have presented a pilot study describing the differences in the early immune response for patients both mildly and severely infected with nvH1N1. Patients who develop severe symptoms after nvH1N1 infection showed Th1 and Th17 'hypercytokinemia', compared to mildly infected patients and healthy controls. The mediators involved with the Th1 and Th17 profiles are known to be involved in antiviral, pro-inflammatory and autoimmune responses. This is the first work reporting the association of a pro-inflamatory immune response with a severe pandemic infection, although it is likely that more studies are needed to understand the detrimental or beneficial roles these cytokines play in the evolution of mild and severe nvH1N1 infection.BioMed Central (BMC)Instituto de Salud Carlos III20192019-05-2120102010-01-0120102010-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/20.500.12105/7622reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)InglésengES PI08 0738ES UIPY1467 07ES CM09 00031ES CM08 00101open accesshttp://purl.org/coar/access_right/c_abf2Atribución-NoComercial-CompartirIgual 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/76222026-06-12T12:43:37Z
dc.title.none.fl_str_mv First evidence of a pro-inflammatory response to severe infection with influenza virus H1N1
title First evidence of a pro-inflammatory response to severe infection with influenza virus H1N1
spellingShingle First evidence of a pro-inflammatory response to severe infection with influenza virus H1N1
Fernández de Castro, Isabel
Case-Control Studies
Cytokines
Humans
Inflammation
Influenza A Virus, H1N1 Subtype
Influenza, Human
title_short First evidence of a pro-inflammatory response to severe infection with influenza virus H1N1
title_full First evidence of a pro-inflammatory response to severe infection with influenza virus H1N1
title_fullStr First evidence of a pro-inflammatory response to severe infection with influenza virus H1N1
title_full_unstemmed First evidence of a pro-inflammatory response to severe infection with influenza virus H1N1
title_sort First evidence of a pro-inflammatory response to severe infection with influenza virus H1N1
dc.creator.none.fl_str_mv Fernández de Castro, Isabel
Guzman-Fulgencio, Maria
Garcia-Alvarez, Monica
Resino, Salvador
author Fernández de Castro, Isabel
author_facet Fernández de Castro, Isabel
Guzman-Fulgencio, Maria
Garcia-Alvarez, Monica
Resino, Salvador
author_role author
author2 Guzman-Fulgencio, Maria
Garcia-Alvarez, Monica
Resino, Salvador
author2_role author
author
author
dc.contributor.none.fl_str_mv Instituto de Salud Carlos III
dc.subject.none.fl_str_mv Case-Control Studies
Cytokines
Humans
Inflammation
Influenza A Virus, H1N1 Subtype
Influenza, Human
topic Case-Control Studies
Cytokines
Humans
Inflammation
Influenza A Virus, H1N1 Subtype
Influenza, Human
description The great majority of infections caused by the pandemic variant of the influenza virus (nvH1N1) are self-limited, but a small percentage of patients develop severe symptoms requiring hospitalization. Bermejo-Martin and colleagues have presented a pilot study describing the differences in the early immune response for patients both mildly and severely infected with nvH1N1. Patients who develop severe symptoms after nvH1N1 infection showed Th1 and Th17 'hypercytokinemia', compared to mildly infected patients and healthy controls. The mediators involved with the Th1 and Th17 profiles are known to be involved in antiviral, pro-inflammatory and autoimmune responses. This is the first work reporting the association of a pro-inflamatory immune response with a severe pandemic infection, although it is likely that more studies are needed to understand the detrimental or beneficial roles these cytokines play in the evolution of mild and severe nvH1N1 infection.
publishDate 2010
dc.date.none.fl_str_mv 2010
2010-01-01
2010
2010-01-01
2019
2019-05-21
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/7622
url http://hdl.handle.net/20.500.12105/7622
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv ES PI08 0738
ES UIPY1467 07
ES CM09 00031
ES CM08 00101
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución-NoComercial-CompartirIgual 4.0 Internacional
http://creativecommons.org/licenses/by-nc-sa/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución-NoComercial-CompartirIgual 4.0 Internacional
http://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BioMed Central (BMC)
publisher.none.fl_str_mv BioMed Central (BMC)
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869423573299363840
score 15,811543

Similares en LA Referencia