Adenosine and Metabotropic Glutamate Receptors Are Present in Blood Serum and Exosomes from SAMP8 Mice: Modulation by Aging and Resveratrol

Adenosine (ARs) and metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors (GPCRs) that are modulated in the brain of SAMP8 mice, an animal model of Alzheimer's disease (AD). In the present work, it is shown the presence of ARs and mGluRs in blood serum and derived exosomes f...

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Detalles Bibliográficos
Autores: Sánchez-Melgar, Alejandro, Albasanz, José Luis, Griñán Ferré, Christian, Pallàs i Llibería, Mercè, 1964-, Martín, Mairena
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/174828
Acceso en línea:https://hdl.handle.net/2445/174828
Access Level:acceso abierto
Palabra clave:Adenosina
Envelliment
Malalties neurodegeneratives
Adenosine
Aging
Neurodegenerative Diseases
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spelling Adenosine and Metabotropic Glutamate Receptors Are Present in Blood Serum and Exosomes from SAMP8 Mice: Modulation by Aging and ResveratrolSánchez-Melgar, AlejandroAlbasanz, José LuisGriñán Ferré, ChristianPallàs i Llibería, Mercè, 1964-Martín, MairenaAdenosinaEnvellimentMalalties neurodegenerativesAdenosineAgingNeurodegenerative DiseasesAdenosine (ARs) and metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors (GPCRs) that are modulated in the brain of SAMP8 mice, an animal model of Alzheimer's disease (AD). In the present work, it is shown the presence of ARs and mGluRs in blood serum and derived exosomes from SAMP8 mice as well as its possible modulation by aging and resveratrol (RSV) consumption. In blood serum, adenosineA1 andA2A receptors remained unaltered from 5 to 7 months of age. However, an age-related decrease in adenosine level was observed, while 50-Nucleotidase activity was not modulated. Regarding the glutamatergic system, it was observed a decrease in mGluR5 density and glutamate levels in older mice. In addition, dietary RSV supplementation caused an age-dependent modulation in both adenosinergic and glutamatergic systems. These GPCRs were also found in blood serum-derived exosomes, which might suggest that these receptors could be released into circulation via exosomes. Interestingly, changes elicited by age and RSV supplementation on mGluR5 density, and adenosine and glutamate levels were similar to that detected in whole-brain. Therefore, we might suggest that the quantification of these receptors, and their corresponding endogenous ligands, in blood serum could have predictive value for early diagnosis in combination with other distinctive hallmarks of AD.MDPI2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/174828Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3390/cells9071628Cells, 2020, vol. 9(7), num. 1628https://doi.org/10.3390/cells9071628cc-by (c) Sánchez-Melgar, Alejandro et al., 2020http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1748282026-05-27T06:46:51Z
dc.title.none.fl_str_mv Adenosine and Metabotropic Glutamate Receptors Are Present in Blood Serum and Exosomes from SAMP8 Mice: Modulation by Aging and Resveratrol
title Adenosine and Metabotropic Glutamate Receptors Are Present in Blood Serum and Exosomes from SAMP8 Mice: Modulation by Aging and Resveratrol
spellingShingle Adenosine and Metabotropic Glutamate Receptors Are Present in Blood Serum and Exosomes from SAMP8 Mice: Modulation by Aging and Resveratrol
Sánchez-Melgar, Alejandro
Adenosina
Envelliment
Malalties neurodegeneratives
Adenosine
Aging
Neurodegenerative Diseases
title_short Adenosine and Metabotropic Glutamate Receptors Are Present in Blood Serum and Exosomes from SAMP8 Mice: Modulation by Aging and Resveratrol
title_full Adenosine and Metabotropic Glutamate Receptors Are Present in Blood Serum and Exosomes from SAMP8 Mice: Modulation by Aging and Resveratrol
title_fullStr Adenosine and Metabotropic Glutamate Receptors Are Present in Blood Serum and Exosomes from SAMP8 Mice: Modulation by Aging and Resveratrol
title_full_unstemmed Adenosine and Metabotropic Glutamate Receptors Are Present in Blood Serum and Exosomes from SAMP8 Mice: Modulation by Aging and Resveratrol
title_sort Adenosine and Metabotropic Glutamate Receptors Are Present in Blood Serum and Exosomes from SAMP8 Mice: Modulation by Aging and Resveratrol
dc.creator.none.fl_str_mv Sánchez-Melgar, Alejandro
Albasanz, José Luis
Griñán Ferré, Christian
Pallàs i Llibería, Mercè, 1964-
Martín, Mairena
author Sánchez-Melgar, Alejandro
author_facet Sánchez-Melgar, Alejandro
Albasanz, José Luis
Griñán Ferré, Christian
Pallàs i Llibería, Mercè, 1964-
Martín, Mairena
author_role author
author2 Albasanz, José Luis
Griñán Ferré, Christian
Pallàs i Llibería, Mercè, 1964-
Martín, Mairena
author2_role author
author
author
author
dc.subject.none.fl_str_mv Adenosina
Envelliment
Malalties neurodegeneratives
Adenosine
Aging
Neurodegenerative Diseases
topic Adenosina
Envelliment
Malalties neurodegeneratives
Adenosine
Aging
Neurodegenerative Diseases
description Adenosine (ARs) and metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors (GPCRs) that are modulated in the brain of SAMP8 mice, an animal model of Alzheimer's disease (AD). In the present work, it is shown the presence of ARs and mGluRs in blood serum and derived exosomes from SAMP8 mice as well as its possible modulation by aging and resveratrol (RSV) consumption. In blood serum, adenosineA1 andA2A receptors remained unaltered from 5 to 7 months of age. However, an age-related decrease in adenosine level was observed, while 50-Nucleotidase activity was not modulated. Regarding the glutamatergic system, it was observed a decrease in mGluR5 density and glutamate levels in older mice. In addition, dietary RSV supplementation caused an age-dependent modulation in both adenosinergic and glutamatergic systems. These GPCRs were also found in blood serum-derived exosomes, which might suggest that these receptors could be released into circulation via exosomes. Interestingly, changes elicited by age and RSV supplementation on mGluR5 density, and adenosine and glutamate levels were similar to that detected in whole-brain. Therefore, we might suggest that the quantification of these receptors, and their corresponding endogenous ligands, in blood serum could have predictive value for early diagnosis in combination with other distinctive hallmarks of AD.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/174828
url https://hdl.handle.net/2445/174828
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/cells9071628
Cells, 2020, vol. 9(7), num. 1628
https://doi.org/10.3390/cells9071628
dc.rights.none.fl_str_mv cc-by (c) Sánchez-Melgar, Alejandro et al., 2020
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Sánchez-Melgar, Alejandro et al., 2020
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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