Germline development in amniotes: A paradigm shift in primordial germ cell specification

In the field of germline development in amniote vertebrates, primordial germ cell (PGC) specification in birds and reptiles remains controversial. Avians are believed to adopt a predetermination or maternal specification mode of PGC formation, contrary to an inductive mode employed by mammals and, s...

Full description

Bibliographic Details
Authors: Bertocchini, Federica, Chuva de Sousa Lopes, Susana M.
Format: article
Status:Published version
Publication Date:2016
Country:España
Institution:Consejo Superior de Investigaciones Científicas (CSIC)
Repository:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/164505
Online Access:http://hdl.handle.net/10261/164505
Access Level:Open access
Keyword:Mammals
Amniotes
Chickens
Epigenesis
Evolution
Preformation
Primordial germ cells
id ES_edbb5aacf8dfe280a37f823dcbf10235
oai_identifier_str oai:digital.csic.es:10261/164505
network_acronym_str ES
network_name_str España
repository_id_str
spelling Germline development in amniotes: A paradigm shift in primordial germ cell specificationBertocchini, FedericaChuva de Sousa Lopes, Susana M.MammalsAmniotesChickensEpigenesisEvolutionPreformationPrimordial germ cellsIn the field of germline development in amniote vertebrates, primordial germ cell (PGC) specification in birds and reptiles remains controversial. Avians are believed to adopt a predetermination or maternal specification mode of PGC formation, contrary to an inductive mode employed by mammals and, supposedly, reptiles. Here, we revisit and review some key aspects of PGC development that channelled the current subdivision, and challenge the position of birds and reptiles as well as the ‘binary’ evolutionary model of PGC development in vertebrates. We propose an alternative view on PGC specification where germ plasm plays a role in laying the foundation for the formation of PGC precursors (pPGC), but not necessarily of PGCs. Moreover, inductive mechanisms may be necessary for the transition from pPGCs to PGCs. Within this framework, the implementation of data from birds and reptiles could provide new insights on the evolution of PGC specification in amniotes.This study was funded by grants from the Spanish Ministry of Science and Innovation (BFU2010-19656) and the Fundacion Areces to FB, and Interuniversity Attraction Poles-Phase VII [IUAP/PAI P7/14] to SMCdSL.Peer ReviewedWiley-VCHBelgian Science Policy OfficeMinisterio de Ciencia e Innovación (España)Fundación Ramón ArecesConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2018201820162018info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/164505reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.1002/bies.201600025Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1645052026-05-22T06:33:51Z
dc.title.none.fl_str_mv Germline development in amniotes: A paradigm shift in primordial germ cell specification
title Germline development in amniotes: A paradigm shift in primordial germ cell specification
spellingShingle Germline development in amniotes: A paradigm shift in primordial germ cell specification
Bertocchini, Federica
Mammals
Amniotes
Chickens
Epigenesis
Evolution
Preformation
Primordial germ cells
title_short Germline development in amniotes: A paradigm shift in primordial germ cell specification
title_full Germline development in amniotes: A paradigm shift in primordial germ cell specification
title_fullStr Germline development in amniotes: A paradigm shift in primordial germ cell specification
title_full_unstemmed Germline development in amniotes: A paradigm shift in primordial germ cell specification
title_sort Germline development in amniotes: A paradigm shift in primordial germ cell specification
dc.creator.none.fl_str_mv Bertocchini, Federica
Chuva de Sousa Lopes, Susana M.
author Bertocchini, Federica
author_facet Bertocchini, Federica
Chuva de Sousa Lopes, Susana M.
author_role author
author2 Chuva de Sousa Lopes, Susana M.
author2_role author
dc.contributor.none.fl_str_mv Belgian Science Policy Office
Ministerio de Ciencia e Innovación (España)
Fundación Ramón Areces
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Mammals
Amniotes
Chickens
Epigenesis
Evolution
Preformation
Primordial germ cells
topic Mammals
Amniotes
Chickens
Epigenesis
Evolution
Preformation
Primordial germ cells
description In the field of germline development in amniote vertebrates, primordial germ cell (PGC) specification in birds and reptiles remains controversial. Avians are believed to adopt a predetermination or maternal specification mode of PGC formation, contrary to an inductive mode employed by mammals and, supposedly, reptiles. Here, we revisit and review some key aspects of PGC development that channelled the current subdivision, and challenge the position of birds and reptiles as well as the ‘binary’ evolutionary model of PGC development in vertebrates. We propose an alternative view on PGC specification where germ plasm plays a role in laying the foundation for the formation of PGC precursors (pPGC), but not necessarily of PGCs. Moreover, inductive mechanisms may be necessary for the transition from pPGCs to PGCs. Within this framework, the implementation of data from birds and reptiles could provide new insights on the evolution of PGC specification in amniotes.
publishDate 2016
dc.date.none.fl_str_mv 2016
2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/164505
url http://hdl.handle.net/10261/164505
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.1002/bies.201600025
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley-VCH
publisher.none.fl_str_mv Wiley-VCH
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869423530259513344
score 15,811543

Similar Items