Comparative Study on the Management and Outcomes of Postoperative Crohn's Disease in Older Patients: Data From the ENEIDA Registry

Mañosa, Míriam; Calafat, Margalida; Ricart, Elena; Nos, Pilar; Iglesias, Eva; Riestra, Sabino; Mesonero, Francisco; Calvo, Marta; Guardiola, Jordi; Hernández, Vicent; Rivero, Montserrat; Carpio, Daniel; Mínguez, Miguel; Alba, Cristina; Martín‐Arranz, Maria Dolores; Vela, Milagros; Gomollón, Fernando; García‐López, Santiago; Casbas, Ana Gutiérrez; Calvet, Xavier; González‐Muñoza, Carlos; Barrio, Jesús; Gisbert, Javier P.; Sicilia, Beatriz; Pérez‐Calle, José Lázaro; Bujanda, Luis; Esteve, Maria; Ramos, Laura; Varela, Pilar; Sierra, Mónica; Merino, Olga; Bermejo, Fernando; Barreiro‐de Acosta, Manuel; Perez, Antonio Rodríguez; Márquez‐Mosquera, Lucía; García‐Bosch, Orlando; Rodríguez‐Lago, Iago; Lorente Poyatos, Rufo H.; García Sepulcre, Mariana Fe; Maroto, Nuria; Vega, Pablo; Monfort, David; San Martín, Lucía Zabalsa; Busquets, David; Martinez‐Montiel, Pilar; Riera-Oliver, Joan; Alcain, Guillermo; Llaó, Jordina; Marin, Nacho; Marin‐Jimenez, Ignacio; Sesé, Eva; Van Domselaar, Manuel; Huguet, José M°; Ginard-Vicens, Daniel; Bas‐Cutrina, Francesc; Ber, Yolanda; Roncero, Oscar; Lucendo, Alfredo J.; López‐García, Alicia; Menacho, Margarita; Almela, Pedro; Ponferrada, Ángel; Coronel, Ana Fuentes; Maestro, Sergio; de Jesús Martínez‐Pérez, Teresa; Vilafranca, Carmen Muñoz; Argüelles, Federico; Legido, Jesús; Gilabert, Pau; Charro, Mara; Trapero, Ana M.; Fernández, Hipólito; Frago, Santiago; Villalba, Luis Hernández; Muñoz, Esther; Domènech, Eugeni

Comparative Study on the Management and Outcomes of Postoperative Crohn's Disease in Older Patients: Data From the ENEIDA Registry

ABSTRACT Background Limited data are available on the management and outcomes of postoperative Crohn's disease (CD) in older patients. We aimed to describe the management of CD in the postoperative setting and assess surgical postoperative recurrence (POR) in this population. Methods This was a...

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Autores:	Mañosa, Míriam, Calafat, Margalida, Ricart, Elena, Nos, Pilar, Iglesias, Eva, Riestra, Sabino, Mesonero, Francisco, Calvo, Marta, Guardiola, Jordi, Hernández, Vicent, Rivero, Montserrat, Carpio, Daniel, Mínguez, Miguel, Alba, Cristina, Martín‐Arranz, Maria Dolores, Vela, Milagros, Gomollón, Fernando, García‐López, Santiago, Casbas, Ana Gutiérrez, Calvet, Xavier, González‐Muñoza, Carlos, Barrio, Jesús, Gisbert, Javier P., Sicilia, Beatriz, Pérez‐Calle, José Lázaro, Bujanda, Luis, Esteve, Maria, Ramos, Laura, Varela, Pilar, Sierra, Mónica, Merino, Olga, Bermejo, Fernando, Barreiro‐de Acosta, Manuel, Perez, Antonio Rodríguez, Márquez‐Mosquera, Lucía, García‐Bosch, Orlando, Rodríguez‐Lago, Iago, Lorente Poyatos, Rufo H., García Sepulcre, Mariana Fe, Maroto, Nuria, Vega, Pablo, Monfort, David, San Martín, Lucía Zabalsa, Busquets, David, Martinez‐Montiel, Pilar, Riera-Oliver, Joan, Alcain, Guillermo, Llaó, Jordina, Marin, Nacho, Marin‐Jimenez, Ignacio, Sesé, Eva, Van Domselaar, Manuel, Huguet, José M°, Ginard-Vicens, Daniel, Bas‐Cutrina, Francesc, Ber, Yolanda, Roncero, Oscar, Lucendo, Alfredo J., López‐García, Alicia, Menacho, Margarita, Almela, Pedro, Ponferrada, Ángel, Coronel, Ana Fuentes, Maestro, Sergio, de Jesús Martínez‐Pérez, Teresa, Vilafranca, Carmen Muñoz, Argüelles, Federico, Legido, Jesús, Gilabert, Pau, Charro, Mara, Trapero, Ana M., Fernández, Hipólito, Frago, Santiago, Villalba, Luis Hernández, Muñoz, Esther, Domènech, Eugeni
Tipo de recurso:	artículo
Fecha de publicación:	2025
País:	España
Institución:	Conselleria de Salut i Consum del Govern de les Illes Balears
Repositorio:	Docusalut
Idioma:	inglés
OAI Identifier:	oai:docusalut.com:20.500.13003/26470
Acceso en línea:	https://hdl.handle.net/20.500.13003/26470
Access Level:	acceso abierto
Palabra clave:	Crohn Disease Postoperative Care General Surgery Adult Age Factors Aged Anastomosis, Surgical Case-Control Studies Colectomy Ileum Immunosuppressive Agents Postoperative Complications Recurrence Treatment Outcome Enfermedad de Crohn Cuidados Posoperatorios Cirugía General Adulto Factores de Edad Anciano Anastomosis Quirúrgica Estudios de Casos y Controles Colectomía Íleon Inmunosupresores Complicaciones Posoperatorias Recurrencia Resultado del Tratamiento Crohn's disease older postoperative recurrence surgery

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network_acronym_str	ES
network_name_str	España
repository_id_str
dc.title.none.fl_str_mv	Comparative Study on the Management and Outcomes of Postoperative Crohn's Disease in Older Patients: Data From the ENEIDA Registry
title	Comparative Study on the Management and Outcomes of Postoperative Crohn's Disease in Older Patients: Data From the ENEIDA Registry
spellingShingle	Comparative Study on the Management and Outcomes of Postoperative Crohn's Disease in Older Patients: Data From the ENEIDA Registry Mañosa, Míriam Crohn Disease Postoperative Care General Surgery Adult Age Factors Aged Anastomosis, Surgical Case-Control Studies Colectomy Crohn Disease Ileum Immunosuppressive Agents Postoperative Complications Recurrence Treatment Outcome Enfermedad de Crohn Cuidados Posoperatorios Cirugía General Adulto Factores de Edad Anciano Anastomosis Quirúrgica Estudios de Casos y Controles Colectomía Enfermedad de Crohn Íleon Inmunosupresores Complicaciones Posoperatorias Recurrencia Resultado del Tratamiento Crohn's disease older postoperative recurrence surgery
title_short	Comparative Study on the Management and Outcomes of Postoperative Crohn's Disease in Older Patients: Data From the ENEIDA Registry
title_full	Comparative Study on the Management and Outcomes of Postoperative Crohn's Disease in Older Patients: Data From the ENEIDA Registry
title_fullStr	Comparative Study on the Management and Outcomes of Postoperative Crohn's Disease in Older Patients: Data From the ENEIDA Registry
title_full_unstemmed	Comparative Study on the Management and Outcomes of Postoperative Crohn's Disease in Older Patients: Data From the ENEIDA Registry
title_sort	Comparative Study on the Management and Outcomes of Postoperative Crohn's Disease in Older Patients: Data From the ENEIDA Registry
dc.creator.none.fl_str_mv	Mañosa, Míriam Calafat, Margalida Ricart, Elena Nos, Pilar Iglesias, Eva Riestra, Sabino Mesonero, Francisco Calvo, Marta Guardiola, Jordi Hernández, Vicent Rivero, Montserrat Carpio, Daniel Mínguez, Miguel Alba, Cristina Martín‐Arranz, Maria Dolores Vela, Milagros Gomollón, Fernando García‐López, Santiago Casbas, Ana Gutiérrez Calvet, Xavier González‐Muñoza, Carlos Barrio, Jesús Gisbert, Javier P. Sicilia, Beatriz Pérez‐Calle, José Lázaro Bujanda, Luis Esteve, Maria Ramos, Laura Varela, Pilar Sierra, Mónica Merino, Olga Bermejo, Fernando Barreiro‐de Acosta, Manuel Perez, Antonio Rodríguez Márquez‐Mosquera, Lucía García‐Bosch, Orlando Rodríguez‐Lago, Iago Lorente Poyatos, Rufo H. García Sepulcre, Mariana Fe Maroto, Nuria Vega, Pablo Monfort, David San Martín, Lucía Zabalsa Busquets, David Martinez‐Montiel, Pilar Riera-Oliver, Joan Alcain, Guillermo Llaó, Jordina Marin, Nacho Marin‐Jimenez, Ignacio Sesé, Eva Van Domselaar, Manuel Huguet, José M° Ginard-Vicens, Daniel Bas‐Cutrina, Francesc Ber, Yolanda Roncero, Oscar Lucendo, Alfredo J. López‐García, Alicia Menacho, Margarita Almela, Pedro Ponferrada, Ángel Coronel, Ana Fuentes Maestro, Sergio de Jesús Martínez‐Pérez, Teresa Vilafranca, Carmen Muñoz Argüelles, Federico Legido, Jesús Gilabert, Pau Charro, Mara Trapero, Ana M. Fernández, Hipólito Frago, Santiago Villalba, Luis Hernández Muñoz, Esther Domènech, Eugeni
author	Mañosa, Míriam
author_facet	Mañosa, Míriam Calafat, Margalida Ricart, Elena Nos, Pilar Iglesias, Eva Riestra, Sabino Mesonero, Francisco Calvo, Marta Guardiola, Jordi Hernández, Vicent Rivero, Montserrat Carpio, Daniel Mínguez, Miguel Alba, Cristina Martín‐Arranz, Maria Dolores Vela, Milagros Gomollón, Fernando García‐López, Santiago Casbas, Ana Gutiérrez Calvet, Xavier González‐Muñoza, Carlos Barrio, Jesús Gisbert, Javier P. Sicilia, Beatriz Pérez‐Calle, José Lázaro Bujanda, Luis Esteve, Maria Ramos, Laura Varela, Pilar Sierra, Mónica Merino, Olga Bermejo, Fernando Barreiro‐de Acosta, Manuel Perez, Antonio Rodríguez Márquez‐Mosquera, Lucía García‐Bosch, Orlando Rodríguez‐Lago, Iago Lorente Poyatos, Rufo H. García Sepulcre, Mariana Fe Maroto, Nuria Vega, Pablo Monfort, David San Martín, Lucía Zabalsa Busquets, David Martinez‐Montiel, Pilar Riera-Oliver, Joan Alcain, Guillermo Llaó, Jordina Marin, Nacho Marin‐Jimenez, Ignacio Sesé, Eva Van Domselaar, Manuel Huguet, José M° Ginard-Vicens, Daniel Bas‐Cutrina, Francesc Ber, Yolanda Roncero, Oscar Lucendo, Alfredo J. López‐García, Alicia Menacho, Margarita Almela, Pedro Ponferrada, Ángel Coronel, Ana Fuentes Maestro, Sergio de Jesús Martínez‐Pérez, Teresa Vilafranca, Carmen Muñoz Argüelles, Federico Legido, Jesús Gilabert, Pau Charro, Mara Trapero, Ana M. Fernández, Hipólito Frago, Santiago Villalba, Luis Hernández Muñoz, Esther Domènech, Eugeni
author_role	author
author2	Calafat, Margalida Ricart, Elena Nos, Pilar Iglesias, Eva Riestra, Sabino Mesonero, Francisco Calvo, Marta Guardiola, Jordi Hernández, Vicent Rivero, Montserrat Carpio, Daniel Mínguez, Miguel Alba, Cristina Martín‐Arranz, Maria Dolores Vela, Milagros Gomollón, Fernando García‐López, Santiago Casbas, Ana Gutiérrez Calvet, Xavier González‐Muñoza, Carlos Barrio, Jesús Gisbert, Javier P. Sicilia, Beatriz Pérez‐Calle, José Lázaro Bujanda, Luis Esteve, Maria Ramos, Laura Varela, Pilar Sierra, Mónica Merino, Olga Bermejo, Fernando Barreiro‐de Acosta, Manuel Perez, Antonio Rodríguez Márquez‐Mosquera, Lucía García‐Bosch, Orlando Rodríguez‐Lago, Iago Lorente Poyatos, Rufo H. García Sepulcre, Mariana Fe Maroto, Nuria Vega, Pablo Monfort, David San Martín, Lucía Zabalsa Busquets, David Martinez‐Montiel, Pilar Riera-Oliver, Joan Alcain, Guillermo Llaó, Jordina Marin, Nacho Marin‐Jimenez, Ignacio Sesé, Eva Van Domselaar, Manuel Huguet, José M° Ginard-Vicens, Daniel Bas‐Cutrina, Francesc Ber, Yolanda Roncero, Oscar Lucendo, Alfredo J. López‐García, Alicia Menacho, Margarita Almela, Pedro Ponferrada, Ángel Coronel, Ana Fuentes Maestro, Sergio de Jesús Martínez‐Pérez, Teresa Vilafranca, Carmen Muñoz Argüelles, Federico Legido, Jesús Gilabert, Pau Charro, Mara Trapero, Ana M. Fernández, Hipólito Frago, Santiago Villalba, Luis Hernández Muñoz, Esther Domènech, Eugeni
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv	Crohn Disease Postoperative Care General Surgery Adult Age Factors Aged Anastomosis, Surgical Case-Control Studies Colectomy Crohn Disease Ileum Immunosuppressive Agents Postoperative Complications Recurrence Treatment Outcome Enfermedad de Crohn Cuidados Posoperatorios Cirugía General Adulto Factores de Edad Anciano Anastomosis Quirúrgica Estudios de Casos y Controles Colectomía Enfermedad de Crohn Íleon Inmunosupresores Complicaciones Posoperatorias Recurrencia Resultado del Tratamiento Crohn's disease older postoperative recurrence surgery
topic	Crohn Disease Postoperative Care General Surgery Adult Age Factors Aged Anastomosis, Surgical Case-Control Studies Colectomy Crohn Disease Ileum Immunosuppressive Agents Postoperative Complications Recurrence Treatment Outcome Enfermedad de Crohn Cuidados Posoperatorios Cirugía General Adulto Factores de Edad Anciano Anastomosis Quirúrgica Estudios de Casos y Controles Colectomía Enfermedad de Crohn Íleon Inmunosupresores Complicaciones Posoperatorias Recurrencia Resultado del Tratamiento Crohn's disease older postoperative recurrence surgery
description	ABSTRACT Background Limited data are available on the management and outcomes of postoperative Crohn's disease (CD) in older patients. We aimed to describe the management of CD in the postoperative setting and assess surgical postoperative recurrence (POR) in this population. Methods This was a case‐control study including all adult patients with CD from the ENEIDA registry who had undergone a first intestinal resection with ileo‐colonic anastomosis. Patients were grouped according to their age at the time of the first surgery in older (over 60 years) subjects and controls (between 18 and 60 years of age). Results A total of 3982 (535 older subjects and 3454 controls) underwent a first intestinal resection for CD with an ileo‐colonic anastomosis. Time from CD diagnosis to surgery was significantly longer in older patients (114 ± 128 vs. 93 ± 97 months; p < 0.001). Older patients also had a lower proportion of penetrating CD (25% vs. 39%; p < 0.0001) and perianal disease (14% vs. 25%; p < 0.0001). A significantly lower proportion of older patients started preventive therapies for POR (32% vs. 51%; p < 0.0001). The cumulative risk of surgical POR was 3.2%, 5.3% and 10.1% in the older group and 3.6%, 6.6% and 14.2% in the control group at three, five and 10 years, respectively ( p = 0.093). In the multivariate logistic regression analysis, only prevention with thiopurines was associated with a lower risk of surgical POR. Conclusions Although postoperative preventive therapy with immunomodulators or biologicals is prescribed less often in older patients after a first intestinal resection, they develop surgical POR as often as younger adult patients.
publishDate	2025
dc.date.none.fl_str_mv	2025 2025-12-06 2025 2025-12-06
dc.type.none.fl_str_mv	research article http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://hdl.handle.net/20.500.13003/26470
url	https://hdl.handle.net/20.500.13003/26470
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	Wiley
publisher.none.fl_str_mv	Wiley
dc.source.none.fl_str_mv	reponame:Docusalut instname:Conselleria de Salut i Consum del Govern de les Illes Balears
instname_str	Conselleria de Salut i Consum del Govern de les Illes Balears
reponame_str	Docusalut
collection	Docusalut
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling	Comparative Study on the Management and Outcomes of Postoperative Crohn's Disease in Older Patients: Data From the ENEIDA RegistryMañosa, MíriamCalafat, MargalidaRicart, ElenaNos, PilarIglesias, EvaRiestra, SabinoMesonero, FranciscoCalvo, MartaGuardiola, JordiHernández, VicentRivero, MontserratCarpio, DanielMínguez, MiguelAlba, CristinaMartín‐Arranz, Maria DoloresVela, MilagrosGomollón, FernandoGarcía‐López, SantiagoCasbas, Ana GutiérrezCalvet, XavierGonzález‐Muñoza, CarlosBarrio, JesúsGisbert, Javier P.Sicilia, BeatrizPérez‐Calle, José LázaroBujanda, LuisEsteve, MariaRamos, LauraVarela, PilarSierra, MónicaMerino, OlgaBermejo, FernandoBarreiro‐de Acosta, ManuelPerez, Antonio RodríguezMárquez‐Mosquera, LucíaGarcía‐Bosch, OrlandoRodríguez‐Lago, IagoLorente Poyatos, Rufo H.García Sepulcre, Mariana FeMaroto, NuriaVega, PabloMonfort, DavidSan Martín, Lucía ZabalsaBusquets, DavidMartinez‐Montiel, PilarRiera-Oliver, JoanAlcain, GuillermoLlaó, JordinaMarin, NachoMarin‐Jimenez, IgnacioSesé, EvaVan Domselaar, ManuelHuguet, José M°Ginard-Vicens, DanielBas‐Cutrina, FrancescBer, YolandaRoncero, OscarLucendo, Alfredo J.López‐García, AliciaMenacho, MargaritaAlmela, PedroPonferrada, ÁngelCoronel, Ana FuentesMaestro, Sergiode Jesús Martínez‐Pérez, TeresaVilafranca, Carmen MuñozArgüelles, FedericoLegido, JesúsGilabert, PauCharro, MaraTrapero, Ana M.Fernández, HipólitoFrago, SantiagoVillalba, Luis HernándezMuñoz, EstherDomènech, EugeniCrohn DiseasePostoperative CareGeneral SurgeryAdultAge FactorsAgedAnastomosis, SurgicalCase-Control StudiesColectomyCrohn DiseaseIleumImmunosuppressive AgentsPostoperative ComplicationsRecurrenceTreatment OutcomeEnfermedad de CrohnCuidados PosoperatoriosCirugía GeneralAdultoFactores de EdadAncianoAnastomosis QuirúrgicaEstudios de Casos y ControlesColectomíaEnfermedad de CrohnÍleonInmunosupresoresComplicaciones PosoperatoriasRecurrenciaResultado del TratamientoCrohn's diseaseolderpostoperative recurrencesurgeryABSTRACT Background Limited data are available on the management and outcomes of postoperative Crohn's disease (CD) in older patients. We aimed to describe the management of CD in the postoperative setting and assess surgical postoperative recurrence (POR) in this population. Methods This was a case‐control study including all adult patients with CD from the ENEIDA registry who had undergone a first intestinal resection with ileo‐colonic anastomosis. Patients were grouped according to their age at the time of the first surgery in older (over 60 years) subjects and controls (between 18 and 60 years of age). Results A total of 3982 (535 older subjects and 3454 controls) underwent a first intestinal resection for CD with an ileo‐colonic anastomosis. Time from CD diagnosis to surgery was significantly longer in older patients (114 ± 128 vs. 93 ± 97 months; p < 0.001). Older patients also had a lower proportion of penetrating CD (25% vs. 39%; p < 0.0001) and perianal disease (14% vs. 25%; p < 0.0001). A significantly lower proportion of older patients started preventive therapies for POR (32% vs. 51%; p < 0.0001). The cumulative risk of surgical POR was 3.2%, 5.3% and 10.1% in the older group and 3.6%, 6.6% and 14.2% in the control group at three, five and 10 years, respectively ( p = 0.093). In the multivariate logistic regression analysis, only prevention with thiopurines was associated with a lower risk of surgical POR. Conclusions Although postoperative preventive therapy with immunomodulators or biologicals is prescribed less often in older patients after a first intestinal resection, they develop surgical POR as often as younger adult patients.Wiley20252025-12-0620252025-12-06research articlehttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.13003/26470reponame:Docusalutinstname:Conselleria de Salut i Consum del Govern de les Illes BalearsInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:docusalut.com:20.500.13003/264702026-06-22T12:44:07Z
score	15.811543

Comparative Study on the Management and Outcomes of Postoperative Crohn's Disease in Older Patients: Data From the ENEIDA Registry

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