Short-course radiotherapy for rectal cancer: real-world evidence in Argentina

Latin America; Rectal cancer; Short-course radiotherapy

Detalles Bibliográficos
Autores: Freile, Berenice, Galli, Mariana, Sanchez Loria, Fernando, Tissera, Natalia Soledad, Waisberg, Federico, Esteso, Federico
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:11351/10324
Acceso en línea:https://hdl.handle.net/11351/10324
http://hdl.handle.net/11351/10324
Access Level:acceso abierto
Palabra clave:Recte - Càncer - Radioteràpia
DISEASES::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms::Rectal Neoplasms
Other subheadings::Other subheadings::Other subheadings::/radiotherapy
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias del sistema digestivo::neoplasias gastrointestinales::neoplasias intestinales::neoplasias colorrectales::neoplasias del recto
Otros calificadores::Otros calificadores::Otros calificadores::/radioterapia
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spelling Short-course radiotherapy for rectal cancer: real-world evidence in ArgentinaFreile, BereniceGalli, MarianaSanchez Loria, FernandoTissera, Natalia SoledadWaisberg, FedericoEsteso, FedericoRecte - Càncer - RadioteràpiaDISEASES::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms::Rectal NeoplasmsOther subheadings::Other subheadings::Other subheadings::/radiotherapyENFERMEDADES::neoplasias::neoplasias por localización::neoplasias del sistema digestivo::neoplasias gastrointestinales::neoplasias intestinales::neoplasias colorrectales::neoplasias del rectoOtros calificadores::Otros calificadores::Otros calificadores::/radioterapiaLatin America; Rectal cancer; Short-course radiotherapyAmérica Latina; Cáncer de recto; Radioterapia de corta duraciónAmèrica Llatina; Càncer de recte; Radioteràpia de curta duradaBackground: Short-course radiotherapy (SCRT) of 25 Gy in five daily fractions is a recommended strategy in the neoadjuvant setting for resectable locally advanced rectal cancer (LARC), as well as in cases of metastatic disease for local control. There is scarce information regarding the use of SCRT for patients who have received nonoperative management. Objectives: To describe the characteristics of patients who received treatment with SCRT for LARC and metastatic rectal cancer, toxicity, and the approach after radiation treatment. Methods: This is a retrospective analysis of all patients who underwent SCRT for rectal cancer at the Alexander Fleming Institute from March 2014 to June 2022. Results: In total, 44 patients were treated with SCRT. The majority were male (29, 66%), with a median age of 59 years (interquartile range 46–73). Most patients had stage IV disease (26, 59.1%), followed by LARC (18, 40.9%). Most lesions were located in the middle rectum (30, 68%). The majority of LARC patients underwent SCRT followed by consolidation chemotherapy (ChT) (16/18, 89%), while most patients with metastatic disease underwent SCRT followed by consolidation ChT (14/26, 53.8%). A clinical complete response (cCR) was documented in 8/44, 18.2% of patients. Most patients with LARC and cCR were managed by a watch and wait approach (5/18, 27.7%). Local recurrence was observed in LARC cases (2/18, 11.1%). Patients who underwent SCRT following consolidation ChT were more likely to have adverse events (AEs) than those undergoing induction ChT following SCRT (11/30, 36.7% versus 3/12, 25%, p = 0.02) Conclusion: In a subgroup of patients diagnosed with LARC and treated with SCRT followed by ChT, surgical treatment could be omitted after they achieved a cCR. Local recurrence was similar to that reported in a previous study. SCRT is a reasonable option for local disease control in stage IV disease, yielding low toxicity rates. Therefore, decisions must be made by a multidisciplinary team. Prospective studies are necessary to reach further conclusions.ecancerInstitut Català de la Salut[Tissera NS] Upper Gastrointestinal Cancer Translational Research Group, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Freile B, Waisberg F, Esteso F] Department of Oncology, Alexander Fleming Institute, Argentina. [Galli M] Department of Radiotherapy, Alexander Fleming Institute, Argentina. [Sanchez Loria F] Department of Surgery, Alexander Fleming Institute, ArgentinaVall d'Hebron Barcelona Hospital Campus202320232023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/10324http://hdl.handle.net/11351/10324Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)Inglésecancermedicalscience;17https://doi.org/10.3332/ecancer.2023.1555Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:11351/103242026-05-29T05:05:01Z
dc.title.none.fl_str_mv Short-course radiotherapy for rectal cancer: real-world evidence in Argentina
title Short-course radiotherapy for rectal cancer: real-world evidence in Argentina
spellingShingle Short-course radiotherapy for rectal cancer: real-world evidence in Argentina
Freile, Berenice
Recte - Càncer - Radioteràpia
DISEASES::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms::Rectal Neoplasms
Other subheadings::Other subheadings::Other subheadings::/radiotherapy
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias del sistema digestivo::neoplasias gastrointestinales::neoplasias intestinales::neoplasias colorrectales::neoplasias del recto
Otros calificadores::Otros calificadores::Otros calificadores::/radioterapia
title_short Short-course radiotherapy for rectal cancer: real-world evidence in Argentina
title_full Short-course radiotherapy for rectal cancer: real-world evidence in Argentina
title_fullStr Short-course radiotherapy for rectal cancer: real-world evidence in Argentina
title_full_unstemmed Short-course radiotherapy for rectal cancer: real-world evidence in Argentina
title_sort Short-course radiotherapy for rectal cancer: real-world evidence in Argentina
dc.creator.none.fl_str_mv Freile, Berenice
Galli, Mariana
Sanchez Loria, Fernando
Tissera, Natalia Soledad
Waisberg, Federico
Esteso, Federico
author Freile, Berenice
author_facet Freile, Berenice
Galli, Mariana
Sanchez Loria, Fernando
Tissera, Natalia Soledad
Waisberg, Federico
Esteso, Federico
author_role author
author2 Galli, Mariana
Sanchez Loria, Fernando
Tissera, Natalia Soledad
Waisberg, Federico
Esteso, Federico
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Tissera NS] Upper Gastrointestinal Cancer Translational Research Group, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Freile B, Waisberg F, Esteso F] Department of Oncology, Alexander Fleming Institute, Argentina. [Galli M] Department of Radiotherapy, Alexander Fleming Institute, Argentina. [Sanchez Loria F] Department of Surgery, Alexander Fleming Institute, Argentina
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Recte - Càncer - Radioteràpia
DISEASES::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms::Rectal Neoplasms
Other subheadings::Other subheadings::Other subheadings::/radiotherapy
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias del sistema digestivo::neoplasias gastrointestinales::neoplasias intestinales::neoplasias colorrectales::neoplasias del recto
Otros calificadores::Otros calificadores::Otros calificadores::/radioterapia
topic Recte - Càncer - Radioteràpia
DISEASES::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms::Rectal Neoplasms
Other subheadings::Other subheadings::Other subheadings::/radiotherapy
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias del sistema digestivo::neoplasias gastrointestinales::neoplasias intestinales::neoplasias colorrectales::neoplasias del recto
Otros calificadores::Otros calificadores::Otros calificadores::/radioterapia
description Latin America; Rectal cancer; Short-course radiotherapy
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/10324
http://hdl.handle.net/11351/10324
url https://hdl.handle.net/11351/10324
http://hdl.handle.net/11351/10324
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv ecancermedicalscience;17
https://doi.org/10.3332/ecancer.2023.1555
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv ecancer
publisher.none.fl_str_mv ecancer
dc.source.none.fl_str_mv Scientia
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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