Circadian Patterns of Patients with Type 2 Diabetes and Obstructive Sleep Apnea

Sleep apnea, a condition that modifies sleep and circadian rhythms, is highly prevalent in patients with diabetes. However, it is not known if there is an association between sleep apnea, circadian alterations and glycemic regulation in this type of patient. Here, a polysomnographic study was carrie...

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Autores: Cambras, Trinitat, Romero, Odile, Díez Noguera, Antoni, Lecube Torelló, Albert, Sampol, Gabriel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universitat de Lleida (UdL)
Repositorio:Repositori Obert UdL
OAI Identifier:oai:repositori.udl.cat:10459.1/72126
Acceso en línea:https://doi.org/10.3390/jcm10020244
http://hdl.handle.net/10459.1/72126
Access Level:acceso abierto
Palabra clave:Glycated hemoglobin
Circadian
Apnea-hypoapnea index
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dc.title.none.fl_str_mv Circadian Patterns of Patients with Type 2 Diabetes and Obstructive Sleep Apnea
title Circadian Patterns of Patients with Type 2 Diabetes and Obstructive Sleep Apnea
spellingShingle Circadian Patterns of Patients with Type 2 Diabetes and Obstructive Sleep Apnea
Cambras, Trinitat
Glycated hemoglobin
Circadian
Apnea-hypoapnea index
title_short Circadian Patterns of Patients with Type 2 Diabetes and Obstructive Sleep Apnea
title_full Circadian Patterns of Patients with Type 2 Diabetes and Obstructive Sleep Apnea
title_fullStr Circadian Patterns of Patients with Type 2 Diabetes and Obstructive Sleep Apnea
title_full_unstemmed Circadian Patterns of Patients with Type 2 Diabetes and Obstructive Sleep Apnea
title_sort Circadian Patterns of Patients with Type 2 Diabetes and Obstructive Sleep Apnea
dc.creator.none.fl_str_mv Cambras, Trinitat
Romero, Odile
Díez Noguera, Antoni
Lecube Torelló, Albert
Sampol, Gabriel
author Cambras, Trinitat
author_facet Cambras, Trinitat
Romero, Odile
Díez Noguera, Antoni
Lecube Torelló, Albert
Sampol, Gabriel
author_role author
author2 Romero, Odile
Díez Noguera, Antoni
Lecube Torelló, Albert
Sampol, Gabriel
author2_role author
author
author
author
dc.subject.none.fl_str_mv Glycated hemoglobin
Circadian
Apnea-hypoapnea index
topic Glycated hemoglobin
Circadian
Apnea-hypoapnea index
description Sleep apnea, a condition that modifies sleep and circadian rhythms, is highly prevalent in patients with diabetes. However, it is not known if there is an association between sleep apnea, circadian alterations and glycemic regulation in this type of patient. Here, a polysomnographic study was carried out on 21 women and 25 men (mean age = 64.3 1.46 years) with diagnoses of type 2 diabetes to detect the presence of sleep apnea. Moreover, patients wore an actigraph and a temperature sensor on the wrist for one week, to study the manifestation of the circadian rhythms. The correlations of circadian and polysomnographic variables with the severity of apnea, measured by the apnea-hypopnea index, and with glycemic dysregulation, measured by the percentage of glycated hemoglobin, were analyzed. The mean apnea-hypoapnea index of all the participants was 39.6 4.3. Apnea-hypoapnea index correlated with % N1, negatively with %N3, and also the stability of the active circadian rhythm. However, no significant correlation was found between the apneahypopnea index and wrist temperature rhythm and glycated hemoglobin. Glycated hemoglobin levels were negatively associated with the percentage of variance explained by the wrist temperature circadian rhythm (calculated via 24 and 12 h rhythms). ThisSleep apnea, a condition that modifies sleep and circadian rhythms, is highly prevalent in patients with diabetes. However, it is not known if there is an association between sleep apnea, circadian alterations and glycemic regulation in this type of patient. Here, a polysomnographic study was carried out on 21 women and 25 men (mean age = 64.3 1.46 years) with diagnoses of type 2 diabetes to detect the presence of sleep apnea. Moreover, patients wore an actigraph and a temperature sensor on the wrist for one week, to study the manifestation of the circadian rhythms. The correlations of circadian and polysomnographic variables with the severity of apnea, measured by the apnea-hypopnea index, and with glycemic dysregulation, measured by the percentage of glycated hemoglobin, were analyzed. The mean apnea-hypoapnea index of all the participants was 39.6 4.3. Apnea-hypoapnea index correlated with % N1, negatively with %N3, and also the stability of the active circadian rhythm. However, no significant correlation was found between the apneahypopnea index and wrist temperature rhythm and glycated hemoglobin. Glycated hemoglobin levels were negatively associated with the percentage of variance explained by the wrist temperature circadian rhythm (calculated via 24 and 12 h rhythms). This association was independent of body mass index and was strongest in patients with severe apnea. In conclusion, patients with diabetes showed altered circadian rhythms associated with a poor glycemic control and this association could partially be related to the coexistence of sleep apnea. association was independent of body mass index and was strongest in patients with severe apnea. In conclusion, patients with diabetes showed altered circadian rhythms associated with a poor glycemic control and this association could partially be related to the coexistence of sleep apnea.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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dc.identifier.none.fl_str_mv https://doi.org/10.3390/jcm10020244
http://hdl.handle.net/10459.1/72126
url https://doi.org/10.3390/jcm10020244
http://hdl.handle.net/10459.1/72126
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a https://doi.org/10.3390/jcm10020244
Journal of Clinical Medicine, 2021, vol. 10, núm. 2, 244
dc.rights.none.fl_str_mv cc-by (c) Cambras et al., 2021
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/4.0/
rights_invalid_str_mv cc-by (c) Cambras et al., 2021
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositori Obert UdL
instname:Universitat de Lleida (UdL)
instname_str Universitat de Lleida (UdL)
reponame_str Repositori Obert UdL
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spelling Circadian Patterns of Patients with Type 2 Diabetes and Obstructive Sleep ApneaCambras, TrinitatRomero, OdileDíez Noguera, AntoniLecube Torelló, AlbertSampol, GabrielGlycated hemoglobinCircadianApnea-hypoapnea indexSleep apnea, a condition that modifies sleep and circadian rhythms, is highly prevalent in patients with diabetes. However, it is not known if there is an association between sleep apnea, circadian alterations and glycemic regulation in this type of patient. Here, a polysomnographic study was carried out on 21 women and 25 men (mean age = 64.3 1.46 years) with diagnoses of type 2 diabetes to detect the presence of sleep apnea. Moreover, patients wore an actigraph and a temperature sensor on the wrist for one week, to study the manifestation of the circadian rhythms. The correlations of circadian and polysomnographic variables with the severity of apnea, measured by the apnea-hypopnea index, and with glycemic dysregulation, measured by the percentage of glycated hemoglobin, were analyzed. The mean apnea-hypoapnea index of all the participants was 39.6 4.3. Apnea-hypoapnea index correlated with % N1, negatively with %N3, and also the stability of the active circadian rhythm. However, no significant correlation was found between the apneahypopnea index and wrist temperature rhythm and glycated hemoglobin. Glycated hemoglobin levels were negatively associated with the percentage of variance explained by the wrist temperature circadian rhythm (calculated via 24 and 12 h rhythms). ThisSleep apnea, a condition that modifies sleep and circadian rhythms, is highly prevalent in patients with diabetes. However, it is not known if there is an association between sleep apnea, circadian alterations and glycemic regulation in this type of patient. Here, a polysomnographic study was carried out on 21 women and 25 men (mean age = 64.3 1.46 years) with diagnoses of type 2 diabetes to detect the presence of sleep apnea. Moreover, patients wore an actigraph and a temperature sensor on the wrist for one week, to study the manifestation of the circadian rhythms. The correlations of circadian and polysomnographic variables with the severity of apnea, measured by the apnea-hypopnea index, and with glycemic dysregulation, measured by the percentage of glycated hemoglobin, were analyzed. The mean apnea-hypoapnea index of all the participants was 39.6 4.3. Apnea-hypoapnea index correlated with % N1, negatively with %N3, and also the stability of the active circadian rhythm. However, no significant correlation was found between the apneahypopnea index and wrist temperature rhythm and glycated hemoglobin. Glycated hemoglobin levels were negatively associated with the percentage of variance explained by the wrist temperature circadian rhythm (calculated via 24 and 12 h rhythms). This association was independent of body mass index and was strongest in patients with severe apnea. In conclusion, patients with diabetes showed altered circadian rhythms associated with a poor glycemic control and this association could partially be related to the coexistence of sleep apnea. association was independent of body mass index and was strongest in patients with severe apnea. In conclusion, patients with diabetes showed altered circadian rhythms associated with a poor glycemic control and this association could partially be related to the coexistence of sleep apnea.This research was supported by grants from de Instituto de Salud Carlos III ISCIII (Fondo de Investigación Sanitaria PI12/00803 and PI15/00260). European Union (European Regional Development Fund. Fondo Europeo de Desarrollo Regional. FEDER. “Una manera de hacer Europa”). CIBER de Diabetes y Enfermedades Metabólicas Asociadas and CIBER de Enfermedades Respiratorias are initiatives of the Instituto de Salud Carlos III.MDPI2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://doi.org/10.3390/jcm10020244http://hdl.handle.net/10459.1/72126reponame:Repositori Obert UdL instname:Universitat de Lleida (UdL)InglésReproducció del document publicat a https://doi.org/10.3390/jcm10020244Journal of Clinical Medicine, 2021, vol. 10, núm. 2, 244cc-by (c) Cambras et al., 2021info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/4.0/oai:repositori.udl.cat:10459.1/721262026-06-24T12:42:17Z
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