Oral supplementation of 2′-fucosyllactose during lactation improves memory and learning in rats

[EN]Human milk oligosaccharides have been proposed to exert beneficial effects on brain development. During the last decades, most of the studies have focused on the evaluation of sialylated structures but recent experiments have also tested fucosylated oligosaccharides, i.e. 2'-fucosyllactose...

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Autores: Oliveros, Elena, Ramirez, María, Vazquez, Enrique, Barranco, Alejandro, Gruart, Agnes, Delgado-Garcia, Jose Maria, Buck, Rachael, Rueda, Ricardo, Martín Martín, María Jesús
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Institución:Universidad de Salamanca (USAL)
Repositorio:GREDOS. Repositorio Institucional de la Universidad de Salamanca
OAI Identifier:oai:gredos.usal.es:10366/167901
Acceso en línea:http://hdl.handle.net/10366/167901
Access Level:acceso abierto
Palabra clave:2′-Fucosyllactose
Cognitive development
Early Nutrition
Infant formula
Milk oligosaccharides
3206 Ciencias de la Nutrición
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spelling Oral supplementation of 2′-fucosyllactose during lactation improves memory and learning in ratsOliveros, ElenaRamirez, MaríaVazquez, EnriqueBarranco, AlejandroGruart, AgnesDelgado-Garcia, Jose MariaBuck, RachaelRueda, RicardoMartín Martín, María Jesús2′-FucosyllactoseCognitive developmentEarly NutritionInfant formulaMilk oligosaccharides3206 Ciencias de la Nutrición[EN]Human milk oligosaccharides have been proposed to exert beneficial effects on brain development. During the last decades, most of the studies have focused on the evaluation of sialylated structures but recent experiments have also tested fucosylated oligosaccharides, i.e. 2'-fucosyllactose (2'-FL). The present study aimed to determine whether oral 2'-FL has an effect on the development of newborn brain, contributing to enhance cognitive skills later in life. Rat pups received an oral supplementation of 2'-FL (2'-FL group) or water (control group) during the lactation period. Thereafter, animals were maintained on a rodent standard diet. Rats (n=12 rats/group) were evaluated twice, at age 4-6weeks and again at age 1year, using classical behavioral tests. In vivo long-term potentiation (LTP) was also performed at the same ages (n=10 rats/group). Both groups showed similar behavior when the animals were assessed just after weaning (age 4-6weeks), although the 2'-FL group seemed to perform slightly better in Morris Water Maze. At age 1year, 2'-FL rats performed significantly better in the Novel Object Recognition and Y maze paradigms, when compared to controls. In addition, LTP was more intense and longer lasting in the rats supplemented with 2'-FL than in control animals, both in young and adult animals. Oral administration of 2'-FL exclusively during lactation enhanced cognitive abilities, not only in childhood but also in adulthood.Abbott laboratoriesAbbott LaboratoriesElsevier202520252016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10366/167901reponame:GREDOS. Repositorio Institucional de la Universidad de Salamancainstname:Universidad de Salamanca (USAL)InglésAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:gredos.usal.es:10366/1679012026-06-07T06:28:51Z
dc.title.none.fl_str_mv Oral supplementation of 2′-fucosyllactose during lactation improves memory and learning in rats
title Oral supplementation of 2′-fucosyllactose during lactation improves memory and learning in rats
spellingShingle Oral supplementation of 2′-fucosyllactose during lactation improves memory and learning in rats
Oliveros, Elena
2′-Fucosyllactose
Cognitive development
Early Nutrition
Infant formula
Milk oligosaccharides
3206 Ciencias de la Nutrición
title_short Oral supplementation of 2′-fucosyllactose during lactation improves memory and learning in rats
title_full Oral supplementation of 2′-fucosyllactose during lactation improves memory and learning in rats
title_fullStr Oral supplementation of 2′-fucosyllactose during lactation improves memory and learning in rats
title_full_unstemmed Oral supplementation of 2′-fucosyllactose during lactation improves memory and learning in rats
title_sort Oral supplementation of 2′-fucosyllactose during lactation improves memory and learning in rats
dc.creator.none.fl_str_mv Oliveros, Elena
Ramirez, María
Vazquez, Enrique
Barranco, Alejandro
Gruart, Agnes
Delgado-Garcia, Jose Maria
Buck, Rachael
Rueda, Ricardo
Martín Martín, María Jesús
author Oliveros, Elena
author_facet Oliveros, Elena
Ramirez, María
Vazquez, Enrique
Barranco, Alejandro
Gruart, Agnes
Delgado-Garcia, Jose Maria
Buck, Rachael
Rueda, Ricardo
Martín Martín, María Jesús
author_role author
author2 Ramirez, María
Vazquez, Enrique
Barranco, Alejandro
Gruart, Agnes
Delgado-Garcia, Jose Maria
Buck, Rachael
Rueda, Ricardo
Martín Martín, María Jesús
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv 2′-Fucosyllactose
Cognitive development
Early Nutrition
Infant formula
Milk oligosaccharides
3206 Ciencias de la Nutrición
topic 2′-Fucosyllactose
Cognitive development
Early Nutrition
Infant formula
Milk oligosaccharides
3206 Ciencias de la Nutrición
description [EN]Human milk oligosaccharides have been proposed to exert beneficial effects on brain development. During the last decades, most of the studies have focused on the evaluation of sialylated structures but recent experiments have also tested fucosylated oligosaccharides, i.e. 2'-fucosyllactose (2'-FL). The present study aimed to determine whether oral 2'-FL has an effect on the development of newborn brain, contributing to enhance cognitive skills later in life. Rat pups received an oral supplementation of 2'-FL (2'-FL group) or water (control group) during the lactation period. Thereafter, animals were maintained on a rodent standard diet. Rats (n=12 rats/group) were evaluated twice, at age 4-6weeks and again at age 1year, using classical behavioral tests. In vivo long-term potentiation (LTP) was also performed at the same ages (n=10 rats/group). Both groups showed similar behavior when the animals were assessed just after weaning (age 4-6weeks), although the 2'-FL group seemed to perform slightly better in Morris Water Maze. At age 1year, 2'-FL rats performed significantly better in the Novel Object Recognition and Y maze paradigms, when compared to controls. In addition, LTP was more intense and longer lasting in the rats supplemented with 2'-FL than in control animals, both in young and adult animals. Oral administration of 2'-FL exclusively during lactation enhanced cognitive abilities, not only in childhood but also in adulthood.
publishDate 2016
dc.date.none.fl_str_mv 2016
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10366/167901
url http://hdl.handle.net/10366/167901
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:GREDOS. Repositorio Institucional de la Universidad de Salamanca
instname:Universidad de Salamanca (USAL)
instname_str Universidad de Salamanca (USAL)
reponame_str GREDOS. Repositorio Institucional de la Universidad de Salamanca
collection GREDOS. Repositorio Institucional de la Universidad de Salamanca
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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