The effect of short term exposure to outdoor air pollution on fertility
Background: There is evidence to suggest that long term exposure to air pollution could be associated with decreased levels of fertility, although there is controversy as to how short term exposure may compromise fertility in IVF patients and what windows of exposure during the IVF process patients...
| Autores: | , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Universitat Pompeu Fabra |
| Repositorio: | Repositorio Digital de la UPF |
| OAI Identifier: | oai:repositori.upf.edu:10230/53334 |
| Acceso en línea: | http://hdl.handle.net/10230/53334 http://dx.doi.org/10.1186/s12958-021-00838-6 |
| Access Level: | acceso abierto |
| Palabra clave: | Acute exposure Fertility Miscarriage NO2 Nitrogen dioxide PM10 PM2.5 Particulate matter Pregnancy |
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The effect of short term exposure to outdoor air pollution on fertility |
| title |
The effect of short term exposure to outdoor air pollution on fertility |
| spellingShingle |
The effect of short term exposure to outdoor air pollution on fertility González-Comadran, Mireia Acute exposure Fertility Miscarriage NO2 Nitrogen dioxide PM10 PM2.5 Particulate matter Pregnancy |
| title_short |
The effect of short term exposure to outdoor air pollution on fertility |
| title_full |
The effect of short term exposure to outdoor air pollution on fertility |
| title_fullStr |
The effect of short term exposure to outdoor air pollution on fertility |
| title_full_unstemmed |
The effect of short term exposure to outdoor air pollution on fertility |
| title_sort |
The effect of short term exposure to outdoor air pollution on fertility |
| dc.creator.none.fl_str_mv |
González-Comadran, Mireia Jacquemin Leonard, Bénédicte Cirach, Marta Lafuente, Rafael Cole-Hunter, Tom Nieuwenhuijsen, Mark J. Brassesco, Mario Coroleu, Buenaventura Checa Vizcaíno, Miguel Ángel |
| author |
González-Comadran, Mireia |
| author_facet |
González-Comadran, Mireia Jacquemin Leonard, Bénédicte Cirach, Marta Lafuente, Rafael Cole-Hunter, Tom Nieuwenhuijsen, Mark J. Brassesco, Mario Coroleu, Buenaventura Checa Vizcaíno, Miguel Ángel |
| author_role |
author |
| author2 |
Jacquemin Leonard, Bénédicte Cirach, Marta Lafuente, Rafael Cole-Hunter, Tom Nieuwenhuijsen, Mark J. Brassesco, Mario Coroleu, Buenaventura Checa Vizcaíno, Miguel Ángel |
| author2_role |
author author author author author author author author |
| dc.subject.none.fl_str_mv |
Acute exposure Fertility Miscarriage NO2 Nitrogen dioxide PM10 PM2.5 Particulate matter Pregnancy |
| topic |
Acute exposure Fertility Miscarriage NO2 Nitrogen dioxide PM10 PM2.5 Particulate matter Pregnancy |
| description |
Background: There is evidence to suggest that long term exposure to air pollution could be associated with decreased levels of fertility, although there is controversy as to how short term exposure may compromise fertility in IVF patients and what windows of exposure during the IVF process patients could be most vulnerable. Methods: This prospective cohort study aimed to evaluate the impact of acute exposure that air pollution have on reproductive outcomes in different moments of the IVF process. Women undergoing IVF living in Barcelona were recruited. Individual air pollution exposures were modelled at their home address 15 and 3 days before embryo transfer (15D and 3D, respectively), the same day of transfer (D0), and 7 days after (D7). The pollutants modelled were: PM2.5 [particulate matter (PM) ≤2.5 μm], PMcoarse (PM between 2.5 and 10μm), PM10 (PM≤10 μm), PM2.5 abs, and NO2 and NOx. Outcomes were analyzed using multi-level regression models, with adjustment for co-pollutants and confouding factors. Two sensitivity analyses were performed. First, the model was adjusted for subacute exposure (received 15 days before ET). The second analysis was based on the first transfer performed on each patient aiming to exclude patients who failed previous transfers. Results: One hundred ninety-four women were recruited, contributing with data for 486 embryo transfers. Acute and subacute exposure to PMs showed a tendency in increasing miscarriage rate and reducing clinical pregnancy rate, although results were not statistically significant. The first sensitivity analysis, showed a significant risk of miscarriage for PM2.5 exposure on 3D after adjusting for subacute exposure, and an increased risk of achieving no pregnancy for PM2.5, PMcoarse and PM10 on 3D. The second sensitivity analysis showed a significant risk of miscarriage for PM2.5 exposure on 3D, and a significant risk of achieving no pregnancy for PM2.5, PMcoarse and PM10 particularly on 3D. No association was observed for nitrogen dioxides on reproductive outcomes. Conclusions: Exposure to particulate matter has a negative impact on reproductive outcomes in IVF patients. Subacute exposure seems to increase the harmful effect of the acute exposure on miscarriage and pregnancy rates. Nitrogen dioxides do not modify significantly the reproductive success. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021 2022 2022 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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http://hdl.handle.net/10230/53334 http://dx.doi.org/10.1186/s12958-021-00838-6 |
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http://hdl.handle.net/10230/53334 http://dx.doi.org/10.1186/s12958-021-00838-6 |
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Inglés |
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Inglés |
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Reprod Biol Endocrinol. 2021 Oct 6;19(1):151 |
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http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
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http://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf application/pdf |
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BioMed Central |
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BioMed Central |
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reponame:Repositorio Digital de la UPF instname:Universitat Pompeu Fabra |
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Universitat Pompeu Fabra |
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Repositorio Digital de la UPF |
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Repositorio Digital de la UPF |
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1869423506216714240 |
| spelling |
The effect of short term exposure to outdoor air pollution on fertilityGonzález-Comadran, MireiaJacquemin Leonard, BénédicteCirach, MartaLafuente, RafaelCole-Hunter, TomNieuwenhuijsen, Mark J.Brassesco, MarioCoroleu, BuenaventuraCheca Vizcaíno, Miguel ÁngelAcute exposureFertilityMiscarriageNO2Nitrogen dioxidePM10PM2.5Particulate matterPregnancyBackground: There is evidence to suggest that long term exposure to air pollution could be associated with decreased levels of fertility, although there is controversy as to how short term exposure may compromise fertility in IVF patients and what windows of exposure during the IVF process patients could be most vulnerable. Methods: This prospective cohort study aimed to evaluate the impact of acute exposure that air pollution have on reproductive outcomes in different moments of the IVF process. Women undergoing IVF living in Barcelona were recruited. Individual air pollution exposures were modelled at their home address 15 and 3 days before embryo transfer (15D and 3D, respectively), the same day of transfer (D0), and 7 days after (D7). The pollutants modelled were: PM2.5 [particulate matter (PM) ≤2.5 μm], PMcoarse (PM between 2.5 and 10μm), PM10 (PM≤10 μm), PM2.5 abs, and NO2 and NOx. Outcomes were analyzed using multi-level regression models, with adjustment for co-pollutants and confouding factors. Two sensitivity analyses were performed. First, the model was adjusted for subacute exposure (received 15 days before ET). The second analysis was based on the first transfer performed on each patient aiming to exclude patients who failed previous transfers. Results: One hundred ninety-four women were recruited, contributing with data for 486 embryo transfers. Acute and subacute exposure to PMs showed a tendency in increasing miscarriage rate and reducing clinical pregnancy rate, although results were not statistically significant. The first sensitivity analysis, showed a significant risk of miscarriage for PM2.5 exposure on 3D after adjusting for subacute exposure, and an increased risk of achieving no pregnancy for PM2.5, PMcoarse and PM10 on 3D. The second sensitivity analysis showed a significant risk of miscarriage for PM2.5 exposure on 3D, and a significant risk of achieving no pregnancy for PM2.5, PMcoarse and PM10 particularly on 3D. No association was observed for nitrogen dioxides on reproductive outcomes. Conclusions: Exposure to particulate matter has a negative impact on reproductive outcomes in IVF patients. Subacute exposure seems to increase the harmful effect of the acute exposure on miscarriage and pregnancy rates. Nitrogen dioxides do not modify significantly the reproductive success.BioMed Central202220222021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/53334http://dx.doi.org/10.1186/s12958-021-00838-6reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésReprod Biol Endocrinol. 2021 Oct 6;19(1):151© The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/533342026-06-12T07:21:37Z |
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