Fronto-caudate and callosal microstructural alterations: unveiling multimodal MRI biomarkers in early Parkinson&apos

[EN] Objectives This study investigated grey and white matter alterations and their association with motor and cognitive symptoms in early-stage Parkinson's disease (PD).Methods Thirty-one early-stage PD patients and 30 matched healthy controls underwent multimodal MRI (VBM, DTI) and compre...

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Autores: Bernabeu-Sanz, Angela, Fernandez, Eduardo, Morales, Sandra|||0000-0003-0763-1545, Naranjo Ornedo, Valeriana|||0000-0002-0181-3412
Tipo de recurso: artículo
Fecha de publicación:2026
País:España
Institución:Universitat Politècnica de València (UPV)
Repositorio:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
Idioma:inglés
OAI Identifier:oai:dnet:riunet______::ec656f38d2ebd03b6cd9119fe51e25c3
Acceso en línea:https://riunet.upv.es/handle/10251/234838
Access Level:acceso abierto
Palabra clave:Parkinson&apos
s disease
Brain
Diffusion tensor imaging
Caudate connectivity
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network_name_str España
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dc.title.none.fl_str_mv Fronto-caudate and callosal microstructural alterations: unveiling multimodal MRI biomarkers in early Parkinson&apos
s disease
title Fronto-caudate and callosal microstructural alterations: unveiling multimodal MRI biomarkers in early Parkinson&apos
spellingShingle Fronto-caudate and callosal microstructural alterations: unveiling multimodal MRI biomarkers in early Parkinson&apos
Bernabeu-Sanz, Angela
Parkinson&apos
s disease
Brain
Diffusion tensor imaging
Caudate connectivity
title_short Fronto-caudate and callosal microstructural alterations: unveiling multimodal MRI biomarkers in early Parkinson&apos
title_full Fronto-caudate and callosal microstructural alterations: unveiling multimodal MRI biomarkers in early Parkinson&apos
title_fullStr Fronto-caudate and callosal microstructural alterations: unveiling multimodal MRI biomarkers in early Parkinson&apos
title_full_unstemmed Fronto-caudate and callosal microstructural alterations: unveiling multimodal MRI biomarkers in early Parkinson&apos
title_sort Fronto-caudate and callosal microstructural alterations: unveiling multimodal MRI biomarkers in early Parkinson&apos
dc.creator.none.fl_str_mv Bernabeu-Sanz, Angela
Fernandez, Eduardo
Morales, Sandra|||0000-0003-0763-1545
Naranjo Ornedo, Valeriana|||0000-0002-0181-3412
author Bernabeu-Sanz, Angela
author_facet Bernabeu-Sanz, Angela
Fernandez, Eduardo
Morales, Sandra|||0000-0003-0763-1545
Naranjo Ornedo, Valeriana|||0000-0002-0181-3412
author_role author
author2 Fernandez, Eduardo
Morales, Sandra|||0000-0003-0763-1545
Naranjo Ornedo, Valeriana|||0000-0002-0181-3412
author2_role author
author
author
dc.contributor.none.fl_str_mv Escuela Técnica Superior de Ingeniería de Telecomunicación
Departamento de Matemática Aplicada
Departamento de Comunicaciones
Escuela Técnica Superior de Ingeniería Aeroespacial y Diseño Industrial
Instituto Universitario de Investigación en Tecnología Centrada en el Ser Humano
Generalitat Valenciana
Agencia Estatal de Investigación
Universitat Politècnica de València
Ministerio de Economía y Competitividad
Repositorio Institucional de la Universitat Politècnica de València Riunet
dc.subject.none.fl_str_mv Parkinson&apos
s disease
Brain
Diffusion tensor imaging
Caudate connectivity
topic Parkinson&apos
s disease
Brain
Diffusion tensor imaging
Caudate connectivity
description [EN] Objectives This study investigated grey and white matter alterations and their association with motor and cognitive symptoms in early-stage Parkinson's disease (PD).Methods Thirty-one early-stage PD patients and 30 matched healthy controls underwent multimodal MRI (VBM, DTI) and comprehensive clinical/neuropsychological assessments. We assessed grey matter atrophy, white matter microstructure, and caudate-cortical connectivity.Results Parkinson's disease (PD) patients showed selective deficits in memory (FCSRT total recall, P-FDR = .014) and processing speed (SDMT, P-FDR = .025). Voxel-based morphometry (VBM) revealed bilateral caudate atrophy (left, P-FDR = .024; right, P-FDR = .026). Diffusion tensor imaging (DTI) demonstrated widespread microstructural alterations in corpus callosum and major association tracts. Disease duration negatively correlated with corpus callosum streamline counts (superior parietal P-FDR = .02; posterior parietal P-FDR = .004). UPDRS negatively correlated with fractional anisotropy (FA) in occipital (P-FDR = .002) and temporal (P-FDR = .0017) corpus callosum segments. Reduced caudate-cortical streamline density in frontal regions correlated with UPDRS/FCSRT scores; caudate-cingulum streamlines correlated with Mini-Mental State Examination (MMSE) attention/calculation.Conclusions Our findings suggest early functionally relevant degeneration of fronto-caudate and interhemispheric pathways in PD. These structural changes correlate with specific cognitive and motor impairments, and are candidate imaging biomarkers for early PD progression and/or cognitive vulnerability.Advances in Knowledge This is the first tractography study to evaluate connectivity between the caudate nuclei and different frontal lobe regions, unveiling specific white matter alterations in early PD. Our findings suggest that caudate atrophy, though not directly correlated with clinical variables, may underlie or result from impaired caudate-cortical connectivity, potentially accounting for some of the multifaceted PD symptoms.
publishDate 2026
dc.date.none.fl_str_mv 2026
2026-04-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://riunet.upv.es/handle/10251/234838
url https://riunet.upv.es/handle/10251/234838
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023 PDC2022-133952-I00 VALIDACION DE UNA NUEVA NEUROPROTESIS VISUAL CORTICAL
Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023 PID2022-141606OB-I00 DESARROLLO DE UNA NEUROPROTESIS VISUAL CORTICAL AVANZADA PARA PERSONAS CIEGAS
Generalitat Valenciana https://doi.org/10.13039/501100003359 CIPROM%2F2023%2F25
Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 IDI-20130020 TÉCNICAS AVANZADAS DE IMAGEN MÉDICA PARA EL CEREBRO
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reconocimiento - No comercial (by-nc)
http://creativecommons.org/licenses/by-nc/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reconocimiento - No comercial (by-nc)
http://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv British Institute of Radiology
publisher.none.fl_str_mv British Institute of Radiology
dc.source.none.fl_str_mv reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname:Universitat Politècnica de València (UPV)
instname_str Universitat Politècnica de València (UPV)
reponame_str RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
collection RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling Fronto-caudate and callosal microstructural alterations: unveiling multimodal MRI biomarkers in early Parkinson&aposs diseaseBernabeu-Sanz, AngelaFernandez, EduardoMorales, Sandra|||0000-0003-0763-1545Naranjo Ornedo, Valeriana|||0000-0002-0181-3412Parkinson&aposs diseaseBrainDiffusion tensor imagingCaudate connectivity[EN] Objectives This study investigated grey and white matter alterations and their association with motor and cognitive symptoms in early-stage Parkinson's disease (PD).Methods Thirty-one early-stage PD patients and 30 matched healthy controls underwent multimodal MRI (VBM, DTI) and comprehensive clinical/neuropsychological assessments. We assessed grey matter atrophy, white matter microstructure, and caudate-cortical connectivity.Results Parkinson's disease (PD) patients showed selective deficits in memory (FCSRT total recall, P-FDR = .014) and processing speed (SDMT, P-FDR = .025). Voxel-based morphometry (VBM) revealed bilateral caudate atrophy (left, P-FDR = .024; right, P-FDR = .026). Diffusion tensor imaging (DTI) demonstrated widespread microstructural alterations in corpus callosum and major association tracts. Disease duration negatively correlated with corpus callosum streamline counts (superior parietal P-FDR = .02; posterior parietal P-FDR = .004). UPDRS negatively correlated with fractional anisotropy (FA) in occipital (P-FDR = .002) and temporal (P-FDR = .0017) corpus callosum segments. Reduced caudate-cortical streamline density in frontal regions correlated with UPDRS/FCSRT scores; caudate-cingulum streamlines correlated with Mini-Mental State Examination (MMSE) attention/calculation.Conclusions Our findings suggest early functionally relevant degeneration of fronto-caudate and interhemispheric pathways in PD. These structural changes correlate with specific cognitive and motor impairments, and are candidate imaging biomarkers for early PD progression and/or cognitive vulnerability.Advances in Knowledge This is the first tractography study to evaluate connectivity between the caudate nuclei and different frontal lobe regions, unveiling specific white matter alterations in early PD. Our findings suggest that caudate atrophy, though not directly correlated with clinical variables, may underlie or result from impaired caudate-cortical connectivity, potentially accounting for some of the multifaceted PD symptoms.This study was funded by the Centro para el Desarrollo Tecnologico Industrial (CDTI) through the BRAIM project (IDI-20130020) and was partially supported by grants PDC2022-133952-I00 and PID2022-141606OB-I00 from the Spanish Ministerio de Ciencia, Innovacion y Universidades, as well as by grant CIPROM/2023/25 from the Generalitat Valenciana. Funding for open access charge was provided by CRUE-Universitat Politecnica de Valencia.British Institute of RadiologyEscuela Técnica Superior de Ingeniería de TelecomunicaciónDepartamento de Matemática AplicadaDepartamento de ComunicacionesEscuela Técnica Superior de Ingeniería Aeroespacial y Diseño IndustrialInstituto Universitario de Investigación en Tecnología Centrada en el Ser HumanoGeneralitat ValencianaAgencia Estatal de InvestigaciónUniversitat Politècnica de ValènciaMinisterio de Economía y CompetitividadRepositorio Institucional de la Universitat Politècnica de València Riunet20262026-04-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://riunet.upv.es/handle/10251/234838reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valénciainstname:Universitat Politècnica de València (UPV)InglésengAgencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023 PDC2022-133952-I00 VALIDACION DE UNA NUEVA NEUROPROTESIS VISUAL CORTICALAgencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023 PID2022-141606OB-I00 DESARROLLO DE UNA NEUROPROTESIS VISUAL CORTICAL AVANZADA PARA PERSONAS CIEGASGeneralitat Valenciana https://doi.org/10.13039/501100003359 CIPROM%2F2023%2F25Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 IDI-20130020 TÉCNICAS AVANZADAS DE IMAGEN MÉDICA PARA EL CEREBROopen accesshttp://purl.org/coar/access_right/c_abf2Reconocimiento - No comercial (by-nc) http://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:dnet:riunet______::ec656f38d2ebd03b6cd9119fe51e25c32026-06-13T07:49:27Z
score 15,81155

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