Oral-associated bacteria in the gut microbiome of individuals with type 2 diabetes: a secondary analysis of metagenomic data

15 páginas, 6 figuras, 1 tabla

Detalles Bibliográficos
Autores: Franco-Duarte, Ricardo, Saati-Santamaría, Zaki, Choowong, Phannaphat, Dharmarathne, Gangani, Menéndez, Esther, Soares, Pedro, Rito, Teresa, Cheung, Wah, Spahr, Axel, Eberhard, Joerg, Jayasinghe, Thilini N
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/415194
Acceso en línea:http://hdl.handle.net/10261/415194
https://api.elsevier.com/content/abstract/scopus_id/105025109924
Access Level:acceso abierto
Palabra clave:Gut microbiome
Metagenomics
Oral microbiota
Oral-gut axis
Periodontal pathogens
Type 2 diabetes mellitus (T2DM)
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network_name_str España
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dc.title.none.fl_str_mv Oral-associated bacteria in the gut microbiome of individuals with type 2 diabetes: a secondary analysis of metagenomic data
title Oral-associated bacteria in the gut microbiome of individuals with type 2 diabetes: a secondary analysis of metagenomic data
spellingShingle Oral-associated bacteria in the gut microbiome of individuals with type 2 diabetes: a secondary analysis of metagenomic data
Franco-Duarte, Ricardo
Gut microbiome
Metagenomics
Oral microbiota
Oral-gut axis
Periodontal pathogens
Type 2 diabetes mellitus (T2DM)
title_short Oral-associated bacteria in the gut microbiome of individuals with type 2 diabetes: a secondary analysis of metagenomic data
title_full Oral-associated bacteria in the gut microbiome of individuals with type 2 diabetes: a secondary analysis of metagenomic data
title_fullStr Oral-associated bacteria in the gut microbiome of individuals with type 2 diabetes: a secondary analysis of metagenomic data
title_full_unstemmed Oral-associated bacteria in the gut microbiome of individuals with type 2 diabetes: a secondary analysis of metagenomic data
title_sort Oral-associated bacteria in the gut microbiome of individuals with type 2 diabetes: a secondary analysis of metagenomic data
dc.creator.none.fl_str_mv Franco-Duarte, Ricardo
Saati-Santamaría, Zaki
Choowong, Phannaphat
Dharmarathne, Gangani
Menéndez, Esther
Soares, Pedro
Rito, Teresa
Cheung, Wah
Spahr, Axel
Eberhard, Joerg
Jayasinghe, Thilini N
author Franco-Duarte, Ricardo
author_facet Franco-Duarte, Ricardo
Saati-Santamaría, Zaki
Choowong, Phannaphat
Dharmarathne, Gangani
Menéndez, Esther
Soares, Pedro
Rito, Teresa
Cheung, Wah
Spahr, Axel
Eberhard, Joerg
Jayasinghe, Thilini N
author_role author
author2 Saati-Santamaría, Zaki
Choowong, Phannaphat
Dharmarathne, Gangani
Menéndez, Esther
Soares, Pedro
Rito, Teresa
Cheung, Wah
Spahr, Axel
Eberhard, Joerg
Jayasinghe, Thilini N
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
Junta de Castilla y León
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Gut microbiome
Metagenomics
Oral microbiota
Oral-gut axis
Periodontal pathogens
Type 2 diabetes mellitus (T2DM)
topic Gut microbiome
Metagenomics
Oral microbiota
Oral-gut axis
Periodontal pathogens
Type 2 diabetes mellitus (T2DM)
description 15 páginas, 6 figuras, 1 tabla
publishDate 2025
dc.date.none.fl_str_mv 2025
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/415194
https://api.elsevier.com/content/abstract/scopus_id/105025109924
url http://hdl.handle.net/10261/415194
https://api.elsevier.com/content/abstract/scopus_id/105025109924
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.1186/s12903-025-07285-4
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling Oral-associated bacteria in the gut microbiome of individuals with type 2 diabetes: a secondary analysis of metagenomic dataFranco-Duarte, RicardoSaati-Santamaría, ZakiChoowong, PhannaphatDharmarathne, GanganiMenéndez, EstherSoares, PedroRito, TeresaCheung, WahSpahr, AxelEberhard, JoergJayasinghe, Thilini NGut microbiomeMetagenomicsOral microbiotaOral-gut axisPeriodontal pathogensType 2 diabetes mellitus (T2DM)15 páginas, 6 figuras, 1 tablaWith an astounding global prevalence, both diabetes mellitus and gum disease pose significant health concerns. Gum disease has been identified as a risk factor for diabetes mellitus, and its treatment has shown improvements in markers of glucose management. We hypothesised that bacteria commonly associated with the oral microbiome could be disproportionately present in the gut of individuals with type 2 diabetes mellitus (T2DM) compared to healthy controls, suggesting a possible association between oral-associated bacteria and metabolic dysregulation. This hypothesis is supported by known interactions between the oral microbiome and systemic health, particularly the role of inflammation in both conditions. Therefore, we aimed to conduct a secondary analysis of whole-genomic sequencing data of studies published over the last twenty years (2004–2024) related to the gut microbiome of patients with T2DM to identify oral-associated bacteria in their gut compared to healthy individuals. We searched for studies related to the gut microbiome, whole metagenomics, and T2DM in Ovid Medline, EMBASE, and Web of Science databases. Studies that included whole metagenomic data from adult populations of all genders with T2DM were selected, resulting in the reanalysis of metagenomic sequencing data from a total of 9 studies (n = 1,224 metagenomes) for bacterial species data. From the 41,689 gut microbial species identified across the selected studies, 497 were classified as of oral-associated bacteria, corresponding with entries in the Human Oral Microbiome Database (HOMD). These oral bacteria comprised 1.19% of the gut microbiome. Notably, twenty oral-associated bacterial species were statistically significant in their presence among patients with diabetes compared to healthy individuals, irrespective of their abundance. Key oral pathogens included Corynebacterium striatum, Staphylococcus capitis, Kingella kingae, Corynebacterium propinquum, Prevotella sp. oral taxon 820, Prevotella scopos, Selenomonas artemidis, Bordetella pertussis, Selenomonas sp. oral taxon 137, and Staphylococcus hominis. Specifically, periodontal pathogens such as, Porphyromonas gingivalis, Tannerella forsythia, and Capnocytophaga sp. oral taxon 332 were found to be significantly higher in patients with T2DM. These bacteria are associated with conditions like endocarditis, bacteremia, and inflammatory responses, which are prevalent in both diabetes and periodontitis. Although causal relationships cannot be directly established, our findings suggest that bacteria typically originating from the oral cavity may be more prevalent in the gut microbiome of patients with T2DM, supporting the potential role of oral-gut microbial interactions in metabolic dysregulation.RFD and TR are funded by FCT (Fundação para a Ciência e Tecnologia). CEECIND/CP1718/CT0018 and 2023.06638 . CEECIND, respectively. ZSS acknowledge funding from the Ramón y Cajal program through Grant nº RYC2023-045204-I, funded by MCIU/AEI/ and by ESF+, a grant funded by Program EU Horizon Europe (HORIZON-TMA-MSCA-PF-EF; Grant nº 101090267), and funds received by “Escalera de Excelencia” CLU-2025-2-04 co-funded by Consejería de Educación de Castilla y León and FEDER Funds 2021–2027. EM is funded by EUROPEAN UNION’S HORIZON 2020 Marie Sklodowska-Curie Actions (Grant Agreement no. 897795)Peer reviewedBioMed CentralMinisterio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)Junta de Castilla y LeónConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202620262025info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/415194https://api.elsevier.com/content/abstract/scopus_id/105025109924reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.1186/s12903-025-07285-4Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/4151942026-05-22T06:33:51Z
score 15,81155

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