Antioxidant Alternatives in the Treatment of Amyotrophic Lateral Sclerosis: A Comprehensive Review
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that produces a selective loss of the motor neurons of the spinal cord, brain stem and motor cortex. Oxidative stress (OS) associated with mitochondrial dysfunction and the deterioration of the electron transport chain has been shown...
| Authors: | , , , , |
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| Format: | article |
| Publication Date: | 2020 |
| Country: | España |
| Institution: | Universidad Católica de Valencia San Vicente Mártir |
| Repository: | RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir |
| Language: | English |
| OAI Identifier: | oai:riucv.ucv.es:20.500.12466/3214 |
| Online Access: | http://hdl.handle.net/20.500.12466/3214 |
| Access Level: | Open access |
| Keyword: | Amyotrophic lateral sclerosis Neurodegenerative diseases Oxidative stress Mitochondrial dysfunction Nicotinamide riboside Pterostilbene 3207.11 Neuropatología 2411.11 Neurofisiología |
| Summary: | Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that produces a selective loss of the motor neurons of the spinal cord, brain stem and motor cortex. Oxidative stress (OS) associated with mitochondrial dysfunction and the deterioration of the electron transport chain has been shown to be a factor that contributes to neurodegeneration and plays a potential role in the pathogenesis of ALS. The regions of the central nervous system affected have high levels of reactive oxygen species (ROS) and reduced antioxidant defenses. Scientific studies propose treatment with antioxidants to combat the characteristic OS and the regeneration of nicotinamide adenine dinucleotide (NAD+) levels by the use of precursors. This review examines the possible roles of nicotinamide riboside and pterostilbene as therapeutic strategies in ALS. |
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