HPV distribution in cervical cancer in Portugal. A retrospective study from 1928 to 2005

Objectives: To determine human papillomavirus (HPV) types in invasive cervical cancer in Portugal. Methods: Cases diagnosed at the Institute Portugues de Oncologia de Lisboa de Francisco Gentil from the year 1928 to 2005 were selected for HPV DNA detection and genotyping using SPF10/DEIA/LiPA25 syst...

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Authors: Félix, Anna, Alemany i Vilches, Laia, Tous, Sara, Sanjosé Llongueras, Silvia de, Bosch José, Francesc Xavier, 1947-
Format: article
Status:Published version
Publication Date:2016
Country:España
Institution:Universidad de Barcelona
Repository:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/125352
Online Access:https://hdl.handle.net/2445/125352
Access Level:Open access
Keyword:Càncer de coll uterí
Papil·lomavirus
Cervix cancer
Papillomaviruses
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spelling HPV distribution in cervical cancer in Portugal. A retrospective study from 1928 to 2005Félix, AnnaAlemany i Vilches, LaiaTous, SaraSanjosé Llongueras, Silvia deBosch José, Francesc Xavier, 1947-Càncer de coll uteríPapil·lomavirusCervix cancerPapillomavirusesObjectives: To determine human papillomavirus (HPV) types in invasive cervical cancer in Portugal. Methods: Cases diagnosed at the Institute Portugues de Oncologia de Lisboa de Francisco Gentil from the year 1928 to 2005 were selected for HPV DNA detection and genotyping using SPF10/DEIA/LiPA25 system. Results: Of the 1214 samples that were considered appropriate for HPV detection, 714 (58.8%; 95% CI: 56.0-61.6%) were positive for HPV DNA. This detection rate varied being lower in the first 3 decades (31.3%; 50.1%; 46.5%) and higher in the last decades (77.4-95.1%). This difference was due probably to the fixative used in the first three decades. The five most common types identified among HPV positive cases were HPV16 (58.2%), HPV18 (9.2%), HPV33 (6.2%), HPV45 (4.7%) and HPV31 (4.4%). Multiple infections were detected in 2.8% of the cases. HPV16 and 18 accounted for 67.4% of infections. There were no statistically significant changes of these types over the studied period. An increase at patient's age at diagnosis was observed in the last decades (p < 0.001). Conclusion: HPV16 and 18 accounts for almost 70% of cervical cancers in all 9 decades studied and support data that effective vaccination against these 2 types will reduce the cervical burden in Portuguese women.Elsevier2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/125352Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1016/j.pvr.2016.02.003Papillomavirus Research, 2016-12-01, vol. 2, p. 41-45https://doi.org/10.1016/j.pvr.2016.02.003cc by-nc-nd (c) Elsevier B.V., 2016http://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1253522026-05-27T06:46:51Z
dc.title.none.fl_str_mv HPV distribution in cervical cancer in Portugal. A retrospective study from 1928 to 2005
title HPV distribution in cervical cancer in Portugal. A retrospective study from 1928 to 2005
spellingShingle HPV distribution in cervical cancer in Portugal. A retrospective study from 1928 to 2005
Félix, Anna
Càncer de coll uterí
Papil·lomavirus
Cervix cancer
Papillomaviruses
title_short HPV distribution in cervical cancer in Portugal. A retrospective study from 1928 to 2005
title_full HPV distribution in cervical cancer in Portugal. A retrospective study from 1928 to 2005
title_fullStr HPV distribution in cervical cancer in Portugal. A retrospective study from 1928 to 2005
title_full_unstemmed HPV distribution in cervical cancer in Portugal. A retrospective study from 1928 to 2005
title_sort HPV distribution in cervical cancer in Portugal. A retrospective study from 1928 to 2005
dc.creator.none.fl_str_mv Félix, Anna
Alemany i Vilches, Laia
Tous, Sara
Sanjosé Llongueras, Silvia de
Bosch José, Francesc Xavier, 1947-
author Félix, Anna
author_facet Félix, Anna
Alemany i Vilches, Laia
Tous, Sara
Sanjosé Llongueras, Silvia de
Bosch José, Francesc Xavier, 1947-
author_role author
author2 Alemany i Vilches, Laia
Tous, Sara
Sanjosé Llongueras, Silvia de
Bosch José, Francesc Xavier, 1947-
author2_role author
author
author
author
dc.subject.none.fl_str_mv Càncer de coll uterí
Papil·lomavirus
Cervix cancer
Papillomaviruses
topic Càncer de coll uterí
Papil·lomavirus
Cervix cancer
Papillomaviruses
description Objectives: To determine human papillomavirus (HPV) types in invasive cervical cancer in Portugal. Methods: Cases diagnosed at the Institute Portugues de Oncologia de Lisboa de Francisco Gentil from the year 1928 to 2005 were selected for HPV DNA detection and genotyping using SPF10/DEIA/LiPA25 system. Results: Of the 1214 samples that were considered appropriate for HPV detection, 714 (58.8%; 95% CI: 56.0-61.6%) were positive for HPV DNA. This detection rate varied being lower in the first 3 decades (31.3%; 50.1%; 46.5%) and higher in the last decades (77.4-95.1%). This difference was due probably to the fixative used in the first three decades. The five most common types identified among HPV positive cases were HPV16 (58.2%), HPV18 (9.2%), HPV33 (6.2%), HPV45 (4.7%) and HPV31 (4.4%). Multiple infections were detected in 2.8% of the cases. HPV16 and 18 accounted for 67.4% of infections. There were no statistically significant changes of these types over the studied period. An increase at patient's age at diagnosis was observed in the last decades (p < 0.001). Conclusion: HPV16 and 18 accounts for almost 70% of cervical cancers in all 9 decades studied and support data that effective vaccination against these 2 types will reduce the cervical burden in Portuguese women.
publishDate 2016
dc.date.none.fl_str_mv 2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/125352
url https://hdl.handle.net/2445/125352
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1016/j.pvr.2016.02.003
Papillomavirus Research, 2016-12-01, vol. 2, p. 41-45
https://doi.org/10.1016/j.pvr.2016.02.003
dc.rights.none.fl_str_mv cc by-nc-nd (c) Elsevier B.V., 2016
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by-nc-nd (c) Elsevier B.V., 2016
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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