The ENDpoiNTs Project: Novel Testing Strategies for Endocrine Disruptors Linked to Developmental Neurotoxicity

Ubiquitous exposure to endocrine-disrupting chemicals (EDCs) has caused serious concerns about the ability of these chemicals to affect neurodevelopment, among others. Since endocrine disruption (ED)-induced developmental neurotoxicity (DNT) is hardly covered by the chemical testing tools that are c...

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Detalles Bibliográficos
Autores: Lupu, Diana, Andersson, Patrik, Bornehag, Carl-Gustaf, Demeneix, Barbara, Fritsche, Ellen, Gennings, Chris, Lichtensteiger, Walter, Leist, Marcel, Leonards, Pim E. G., Ponsonby, Anne-Louise, Scholze, Martin, Testa, Giuseppe, Fernández-Tresguerres Hernández, Jesús Ángel, Westerink, Remco H. S., Zalc, Bernard, Rüegg, Joëlle
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/8198
Acceso en línea:https://hdl.handle.net/20.500.14352/8198
Access Level:acceso abierto
Palabra clave:endocrine-disrupting chemicals
developmental neurotoxicity
chemical testing
adverse outcome pathways
Endocrinología
Fisiología
3205.02 Endocrinología
2411 Fisiología Humana
Descripción
Sumario:Ubiquitous exposure to endocrine-disrupting chemicals (EDCs) has caused serious concerns about the ability of these chemicals to affect neurodevelopment, among others. Since endocrine disruption (ED)-induced developmental neurotoxicity (DNT) is hardly covered by the chemical testing tools that are currently in regulatory use, the Horizon 2020 research and innovation action ENDpoiNTs has been launched to fill the scientific and methodological gaps related to the assessment of this type of chemical toxicity. The ENDpoiNTs project will generate new knowledge about ED-induced DNT and aims to develop and improve in vitro, in vivo, and in silico models pertaining to ED-linked DNT outcomes for chemical testing. This will be achieved by establishing correlative and causal links between known and novel neurodevelopmental endpoints and endocrine pathways through integration of molecular, cellular, and organismal data from in vitro and in vivo models. Based on this knowledge, the project aims to provide adverse outcome pathways (AOPs) for ED-induced DNT and to develop and integrate new testing tools with high relevance for human health into European and international regulatory frameworks.

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