Wireless networks of injectable microelectronic stimulators based on rectification of volume conducted high frequency currents

Objective. To develop and in vivo demonstrate threadlike wireless implantable neuromuscular microstimulators that are digitally addressable. Approach. These devices perform, through its two electrodes, electronic rectification of innocuous high frequency current bursts delivered by volume conduction...

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Detalles Bibliográficos
Autores: García-Moreno, Aracelys, Comerma-Montells, Albert, Tudela Pi, Marc, Minguillon, Jesus, Becerra Fajardo, Laura, Ivorra Cano, Antoni, 1974-
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/56053
Acceso en línea:http://hdl.handle.net/10230/56053
http://dx.doi.org/10.1088/1741-2552/ac8dc4
Access Level:acceso abierto
Palabra clave:volume conduction
microstimulators
implants
ASIC
wireless power transfer
hermeticity
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spelling Wireless networks of injectable microelectronic stimulators based on rectification of volume conducted high frequency currentsGarcía-Moreno, AracelysComerma-Montells, AlbertTudela Pi, MarcMinguillon, JesusBecerra Fajardo, LauraIvorra Cano, Antoni, 1974-volume conductionmicrostimulatorsimplantsASICwireless power transferhermeticityObjective. To develop and in vivo demonstrate threadlike wireless implantable neuromuscular microstimulators that are digitally addressable. Approach. These devices perform, through its two electrodes, electronic rectification of innocuous high frequency current bursts delivered by volume conduction via epidermal textile electrodes. By avoiding the need of large components to obtain electrical energy, this approach allows the development of thin devices that can be intramuscularly implanted by minimally invasive procedures such as injection. For compliance with electrical safety standards, this approach requires a minimum distance, in the order of millimeters or a very few centimeters, between the implant electrodes. Additionally, the devices must cause minimal mechanical damage to tissues, avoid dislocation and be adequate for long-term implantation. Considering these requirements, the implants were conceived as tubular and flexible devices with two electrodes at opposite ends and, at the middle section, a hermetic metallic capsule housing the electronics. Main results. The developed implants have a submillimetric diameter (0.97 mm diameter, 35 mm length) and consist of a microcircuit, which contains a single custom-developed integrated circuit, housed within a titanium capsule (0.7 mm diameter, 6.5 mm length), and two platinum–iridium coils that form two electrodes (3 mm length) located at opposite ends of a silicone body. These neuromuscular stimulators are addressable, allowing to establish a network of microstimulators that can be controlled independently. Their operation was demonstrated in an acute study by injecting a few of them in the hind limb of anesthetized rabbits and inducing controlled and independent contractions. Significance. These results show the feasibility of manufacturing threadlike wireless addressable neuromuscular stimulators by using fabrication techniques and materials well established for chronic electronic implants. Although long-term operation still must be demonstrated, the obtained results pave the way to the clinical development of advanced motor neuroprostheses formed by dense networks of such wireless devices.This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (Grant Agreement No. 724244). A.I. gratefully acknowledges the financial support by ICREA under the ICREA Academia programme.IOP Publishing Ltd.202320232022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/56053http://dx.doi.org/10.1088/1741-2552/ac8dc4reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésJournal of Neural Engineering. 2022;19(5):056015.info:eu-repo/grantAgreement/EC/H2020/724244© 2022 The Author(s). Published by IOP Publishing Ltd. Original content from this work may be used under the terms of the Creative Commons Attribution 4.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/560532026-05-29T05:05:01Z
dc.title.none.fl_str_mv Wireless networks of injectable microelectronic stimulators based on rectification of volume conducted high frequency currents
title Wireless networks of injectable microelectronic stimulators based on rectification of volume conducted high frequency currents
spellingShingle Wireless networks of injectable microelectronic stimulators based on rectification of volume conducted high frequency currents
García-Moreno, Aracelys
volume conduction
microstimulators
implants
ASIC
wireless power transfer
hermeticity
title_short Wireless networks of injectable microelectronic stimulators based on rectification of volume conducted high frequency currents
title_full Wireless networks of injectable microelectronic stimulators based on rectification of volume conducted high frequency currents
title_fullStr Wireless networks of injectable microelectronic stimulators based on rectification of volume conducted high frequency currents
title_full_unstemmed Wireless networks of injectable microelectronic stimulators based on rectification of volume conducted high frequency currents
title_sort Wireless networks of injectable microelectronic stimulators based on rectification of volume conducted high frequency currents
dc.creator.none.fl_str_mv García-Moreno, Aracelys
Comerma-Montells, Albert
Tudela Pi, Marc
Minguillon, Jesus
Becerra Fajardo, Laura
Ivorra Cano, Antoni, 1974-
author García-Moreno, Aracelys
author_facet García-Moreno, Aracelys
Comerma-Montells, Albert
Tudela Pi, Marc
Minguillon, Jesus
Becerra Fajardo, Laura
Ivorra Cano, Antoni, 1974-
author_role author
author2 Comerma-Montells, Albert
Tudela Pi, Marc
Minguillon, Jesus
Becerra Fajardo, Laura
Ivorra Cano, Antoni, 1974-
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv volume conduction
microstimulators
implants
ASIC
wireless power transfer
hermeticity
topic volume conduction
microstimulators
implants
ASIC
wireless power transfer
hermeticity
description Objective. To develop and in vivo demonstrate threadlike wireless implantable neuromuscular microstimulators that are digitally addressable. Approach. These devices perform, through its two electrodes, electronic rectification of innocuous high frequency current bursts delivered by volume conduction via epidermal textile electrodes. By avoiding the need of large components to obtain electrical energy, this approach allows the development of thin devices that can be intramuscularly implanted by minimally invasive procedures such as injection. For compliance with electrical safety standards, this approach requires a minimum distance, in the order of millimeters or a very few centimeters, between the implant electrodes. Additionally, the devices must cause minimal mechanical damage to tissues, avoid dislocation and be adequate for long-term implantation. Considering these requirements, the implants were conceived as tubular and flexible devices with two electrodes at opposite ends and, at the middle section, a hermetic metallic capsule housing the electronics. Main results. The developed implants have a submillimetric diameter (0.97 mm diameter, 35 mm length) and consist of a microcircuit, which contains a single custom-developed integrated circuit, housed within a titanium capsule (0.7 mm diameter, 6.5 mm length), and two platinum–iridium coils that form two electrodes (3 mm length) located at opposite ends of a silicone body. These neuromuscular stimulators are addressable, allowing to establish a network of microstimulators that can be controlled independently. Their operation was demonstrated in an acute study by injecting a few of them in the hind limb of anesthetized rabbits and inducing controlled and independent contractions. Significance. These results show the feasibility of manufacturing threadlike wireless addressable neuromuscular stimulators by using fabrication techniques and materials well established for chronic electronic implants. Although long-term operation still must be demonstrated, the obtained results pave the way to the clinical development of advanced motor neuroprostheses formed by dense networks of such wireless devices.
publishDate 2022
dc.date.none.fl_str_mv 2022
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/56053
http://dx.doi.org/10.1088/1741-2552/ac8dc4
url http://hdl.handle.net/10230/56053
http://dx.doi.org/10.1088/1741-2552/ac8dc4
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Journal of Neural Engineering. 2022;19(5):056015.
info:eu-repo/grantAgreement/EC/H2020/724244
dc.rights.none.fl_str_mv https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv IOP Publishing Ltd.
publisher.none.fl_str_mv IOP Publishing Ltd.
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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