Bariatric conversion surgery impact on LDL cholesterol in patients previously treated with sleeve gastrectomy

Background/Objectives: Many patients with obesity require conversion bariatric surgery (CBS) after sleeve gastrectomy (SG). The objective of this study was to assess the evolution of LDL cholesterol and other cardiometabolic parameters in patients who have undergone an SG and require a CBS, as the m...

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Autores: Benaiges Foix, David, Calzada, Max, Casajoana, Anna, Deza, Belen, Pera Román, Manuel, Climent, Elisenda, Flores Le Roux, Juana Antonia, Beisani, Marc, Olano, Miguel, Pérez Vega, Karla Alejandra, Pedro-Botet, Juan, Goday Arnó, Albert
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/72677
Acceso en línea:https://hdl.handle.net/10230/72677
http://dx.doi.org/10.3390/jcm14144901
Access Level:acceso abierto
Palabra clave:Bariatric surgery
Conversional bariatric surgery
LDL cholesterol
Single-anastomosis duodeno-ileal bypass with sleeve gastrectomy
Sleeve gastrectomy
Gastric bypass
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spelling Bariatric conversion surgery impact on LDL cholesterol in patients previously treated with sleeve gastrectomyBenaiges Foix, DavidCalzada, MaxCasajoana, AnnaDeza, BelenPera Román, ManuelCliment, ElisendaFlores Le Roux, Juana AntoniaBeisani, MarcOlano, MiguelPérez Vega, Karla AlejandraPedro-Botet, JuanGoday Arnó, AlbertBariatric surgeryConversional bariatric surgeryLDL cholesterolSingle-anastomosis duodeno-ileal bypass with sleeve gastrectomySleeve gastrectomyGastric bypassBackground/Objectives: Many patients with obesity require conversion bariatric surgery (CBS) after sleeve gastrectomy (SG). The objective of this study was to assess the evolution of LDL cholesterol and other cardiometabolic parameters in patients who have undergone an SG and require a CBS, as the metabolic effects of such conversion procedures remain insufficiently understood. Methods: A retrospective analysis was conducted in a non-randomized prospective cohort of patients with severe obesity who were previously treated with SG and undergoing CBS. Changes in LDL cholesterol levels after SG were compared to those following CBS using repeated-measures ANOVA. Results: Twenty-eight patients were included (mean age 44.5 ± 7.2 years; 68% female; mean BMI 47.3 ± 7.2 kg/m). Of these, 57% underwent Roux-en-Y gastric bypass (RYGB), and 43% underwent single-anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S) as conversion procedures. The mean time between SG and CBS was 93.5 ± 45.3 months for RYGB and 31.0 ± 45.2 months for SADI-S. The change in LDL cholesterol pre- vs. post-SG was 3.3 mg/dL (95% CI: -13.6 to 20.1), whereas the change pre- vs. post-CBS was -25.7 mg/dL (95% CI: -37.5 to -13.9) (p < 0.001). Remission of high LDL-C was 18.8% after SG and 73.3% after CBS (p = 0.023). The cardiometabolic profile showed a marked improvement profile during the SG period, followed by maintenance of these improvements during the CBS period. Conclusions: CBS (with either RYGB or SADI-S) results in a reduction in LDL-C, in contrast to the initial surgery with SG. However, CBS does not appear to provide additional benefits over SG in terms of other cardiometabolic parameters.MDPI2026202620252026info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/10230/72677http://dx.doi.org/10.3390/jcm14144901https://hdl.handle.net/10230/72677reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésJournal of Clinical Medicine. 2025;14(14):4901© 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/726772026-05-29T05:05:01Z
dc.title.none.fl_str_mv Bariatric conversion surgery impact on LDL cholesterol in patients previously treated with sleeve gastrectomy
title Bariatric conversion surgery impact on LDL cholesterol in patients previously treated with sleeve gastrectomy
spellingShingle Bariatric conversion surgery impact on LDL cholesterol in patients previously treated with sleeve gastrectomy
Benaiges Foix, David
Bariatric surgery
Conversional bariatric surgery
LDL cholesterol
Single-anastomosis duodeno-ileal bypass with sleeve gastrectomy
Sleeve gastrectomy
Gastric bypass
title_short Bariatric conversion surgery impact on LDL cholesterol in patients previously treated with sleeve gastrectomy
title_full Bariatric conversion surgery impact on LDL cholesterol in patients previously treated with sleeve gastrectomy
title_fullStr Bariatric conversion surgery impact on LDL cholesterol in patients previously treated with sleeve gastrectomy
title_full_unstemmed Bariatric conversion surgery impact on LDL cholesterol in patients previously treated with sleeve gastrectomy
title_sort Bariatric conversion surgery impact on LDL cholesterol in patients previously treated with sleeve gastrectomy
dc.creator.none.fl_str_mv Benaiges Foix, David
Calzada, Max
Casajoana, Anna
Deza, Belen
Pera Román, Manuel
Climent, Elisenda
Flores Le Roux, Juana Antonia
Beisani, Marc
Olano, Miguel
Pérez Vega, Karla Alejandra
Pedro-Botet, Juan
Goday Arnó, Albert
author Benaiges Foix, David
author_facet Benaiges Foix, David
Calzada, Max
Casajoana, Anna
Deza, Belen
Pera Román, Manuel
Climent, Elisenda
Flores Le Roux, Juana Antonia
Beisani, Marc
Olano, Miguel
Pérez Vega, Karla Alejandra
Pedro-Botet, Juan
Goday Arnó, Albert
author_role author
author2 Calzada, Max
Casajoana, Anna
Deza, Belen
Pera Román, Manuel
Climent, Elisenda
Flores Le Roux, Juana Antonia
Beisani, Marc
Olano, Miguel
Pérez Vega, Karla Alejandra
Pedro-Botet, Juan
Goday Arnó, Albert
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Bariatric surgery
Conversional bariatric surgery
LDL cholesterol
Single-anastomosis duodeno-ileal bypass with sleeve gastrectomy
Sleeve gastrectomy
Gastric bypass
topic Bariatric surgery
Conversional bariatric surgery
LDL cholesterol
Single-anastomosis duodeno-ileal bypass with sleeve gastrectomy
Sleeve gastrectomy
Gastric bypass
description Background/Objectives: Many patients with obesity require conversion bariatric surgery (CBS) after sleeve gastrectomy (SG). The objective of this study was to assess the evolution of LDL cholesterol and other cardiometabolic parameters in patients who have undergone an SG and require a CBS, as the metabolic effects of such conversion procedures remain insufficiently understood. Methods: A retrospective analysis was conducted in a non-randomized prospective cohort of patients with severe obesity who were previously treated with SG and undergoing CBS. Changes in LDL cholesterol levels after SG were compared to those following CBS using repeated-measures ANOVA. Results: Twenty-eight patients were included (mean age 44.5 ± 7.2 years; 68% female; mean BMI 47.3 ± 7.2 kg/m). Of these, 57% underwent Roux-en-Y gastric bypass (RYGB), and 43% underwent single-anastomosis duodeno-ileal bypass with sleeve gastrectomy (SADI-S) as conversion procedures. The mean time between SG and CBS was 93.5 ± 45.3 months for RYGB and 31.0 ± 45.2 months for SADI-S. The change in LDL cholesterol pre- vs. post-SG was 3.3 mg/dL (95% CI: -13.6 to 20.1), whereas the change pre- vs. post-CBS was -25.7 mg/dL (95% CI: -37.5 to -13.9) (p < 0.001). Remission of high LDL-C was 18.8% after SG and 73.3% after CBS (p = 0.023). The cardiometabolic profile showed a marked improvement profile during the SG period, followed by maintenance of these improvements during the CBS period. Conclusions: CBS (with either RYGB or SADI-S) results in a reduction in LDL-C, in contrast to the initial surgery with SG. However, CBS does not appear to provide additional benefits over SG in terms of other cardiometabolic parameters.
publishDate 2025
dc.date.none.fl_str_mv 2025
2026
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/10230/72677
http://dx.doi.org/10.3390/jcm14144901
https://hdl.handle.net/10230/72677
url https://hdl.handle.net/10230/72677
http://dx.doi.org/10.3390/jcm14144901
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Journal of Clinical Medicine. 2025;14(14):4901
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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