Insulin resistance modulates gut microbiota and incretin response remodeling after bariatric surgery in severe obesity
This study aims to assess the impact of insulin resistance (IR) on gut microbiota (GM) composition, incretin responses, and metabolic outcomes following sleeve gastrectomy (SG) in people with severe obesity who do not have diabetes. Methods: A prospective single-center study encompassed patients wit...
| Autores: | , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:322281 |
| Acceso en línea: | https://ddd.uab.cat/record/322281 https://dx.doi.org/urn:doi:10.1038/s41366-025-01971-7 |
| Access Level: | acceso abierto |
| Palabra clave: | Insulin resistance Incretin Microbiota Severe obesity Bariatric surgery |
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Insulin resistance modulates gut microbiota and incretin response remodeling after bariatric surgery in severe obesity |
| title |
Insulin resistance modulates gut microbiota and incretin response remodeling after bariatric surgery in severe obesity |
| spellingShingle |
Insulin resistance modulates gut microbiota and incretin response remodeling after bariatric surgery in severe obesity Puig, Rocío Insulin resistance Incretin Microbiota Severe obesity Bariatric surgery |
| title_short |
Insulin resistance modulates gut microbiota and incretin response remodeling after bariatric surgery in severe obesity |
| title_full |
Insulin resistance modulates gut microbiota and incretin response remodeling after bariatric surgery in severe obesity |
| title_fullStr |
Insulin resistance modulates gut microbiota and incretin response remodeling after bariatric surgery in severe obesity |
| title_full_unstemmed |
Insulin resistance modulates gut microbiota and incretin response remodeling after bariatric surgery in severe obesity |
| title_sort |
Insulin resistance modulates gut microbiota and incretin response remodeling after bariatric surgery in severe obesity |
| dc.creator.none.fl_str_mv |
Puig, Rocío Rodríguez-Peña, M-Mar Hernández-Montoliu, Laura Astiarraga, Brenno|||0000-0003-2216-8974 Martínez, Eva Balibrea Del Castillo, José María|||0000-0002-0764-7179 Llauradó, Gemma|||0000-0002-3237-6366 Tarascó, Jordi Caballero, Albert Joaquín, Clara|||0000-0002-9063-4853 Puig Domingo, Manuel|||0000-0002-6744-7195 Vilarrasa, Nuria|||0000-0003-3188-1990 Fernández-Veledo, Sonia|||0000-0003-2906-3788 Vendrell, Joan|||0000-0002-6994-6115 Pellitero, Silvia|||0000-0002-9510-7251 |
| author |
Puig, Rocío |
| author_facet |
Puig, Rocío Rodríguez-Peña, M-Mar Hernández-Montoliu, Laura Astiarraga, Brenno|||0000-0003-2216-8974 Martínez, Eva Balibrea Del Castillo, José María|||0000-0002-0764-7179 Llauradó, Gemma|||0000-0002-3237-6366 Tarascó, Jordi Caballero, Albert Joaquín, Clara|||0000-0002-9063-4853 Puig Domingo, Manuel|||0000-0002-6744-7195 Vilarrasa, Nuria|||0000-0003-3188-1990 Fernández-Veledo, Sonia|||0000-0003-2906-3788 Vendrell, Joan|||0000-0002-6994-6115 Pellitero, Silvia|||0000-0002-9510-7251 |
| author_role |
author |
| author2 |
Rodríguez-Peña, M-Mar Hernández-Montoliu, Laura Astiarraga, Brenno|||0000-0003-2216-8974 Martínez, Eva Balibrea Del Castillo, José María|||0000-0002-0764-7179 Llauradó, Gemma|||0000-0002-3237-6366 Tarascó, Jordi Caballero, Albert Joaquín, Clara|||0000-0002-9063-4853 Puig Domingo, Manuel|||0000-0002-6744-7195 Vilarrasa, Nuria|||0000-0003-3188-1990 Fernández-Veledo, Sonia|||0000-0003-2906-3788 Vendrell, Joan|||0000-0002-6994-6115 Pellitero, Silvia|||0000-0002-9510-7251 |
| author2_role |
author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Insulin resistance Incretin Microbiota Severe obesity Bariatric surgery |
| topic |
Insulin resistance Incretin Microbiota Severe obesity Bariatric surgery |
| description |
This study aims to assess the impact of insulin resistance (IR) on gut microbiota (GM) composition, incretin responses, and metabolic outcomes following sleeve gastrectomy (SG) in people with severe obesity who do not have diabetes. Methods: A prospective single-center study encompassed patients with severe obesity and normal glucose tolerance who underwent SG. Participants were stratified into two cohorts based on the magnitude of their insulin resistance state, as determined by the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) index: high-IR (Hi-IR; HOMA-IR 95th percentile) and low-IR (Lo-IR; HOMA-IR < 25th percentile). Body composition measurements, biochemical analyses, and microbiota assessments were performed before and six months post-surgery. Additionally, the responses to a standardized meal tolerance test (MTT) of glucagon-like peptide-1 (GLP-1) and glucagon-like peptide-2 (GLP-2) were evaluated. Results: The study cohort consisted of 18 patients (9 with Hi-IR and 9 with Lo-IR), with a mean age of 48.8 ± 9.2 years and a mean body mass index (BMI) of 45.03 ± 4.82 kg/m². Six months post-surgery, the mean percentage of total weight loss (WL) was 26.5 ± 6%, with both groups exhibiting enhanced secretion of GLP-1 and GLP-2 following MTT. At baseline, participants exhibited distinct microbiota profiles; the Hi-IR group showed a higher relative abundance of Prevotella species, which are previously associated with adverse metabolic and inflammatory profiles. Post-surgery, both groups exhibited positive incretin responses and significant modifications in GM composition. Notably Hi-IR people experienced more 146 pronounced changes in microbial diversity, including increases in Akkermansia and Veillonella species and decreases in Prevotella species. Enhanced GLP-1 and GLP-2 responses were correlated with WL and metabòlic improvement, particularly in the Lo-IR population. Conclusions: These findings underscore the role of GM in metabolic changes and surgical outcomes after SG. Targeting gut microbiota may offer a promising avenue for improving obesity treatment strategies. |
| publishDate |
2025 |
| dc.date.none.fl_str_mv |
2 2025-01-01 2025 2025-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 AM http://purl.org/coar/version/c_ab4af688f83e57aa |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
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article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/322281 https://dx.doi.org/urn:doi:10.1038/s41366-025-01971-7 |
| url |
https://ddd.uab.cat/record/322281 https://dx.doi.org/urn:doi:10.1038/s41366-025-01971-7 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.relation.none.fl_str_mv |
Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI14/00228 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI17/01503 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI20/00338 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI23/01133 Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI14/00633 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI17/00915 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI20/00114 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI23/01289 Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI14/01997 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI17/01556 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI22/01773 Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 RTI2018-093919-B-100 Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 PID2021-122480OB-584-100 "la Caixa" Foundation https://doi.org/10.13039/100010434 100010434 Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2021/SGR-01409 Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2021/SGR-00089 |
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open access http://purl.org/coar/access_right/c_abf2 https://rightsstatements.org/vocab/InC/1.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://rightsstatements.org/vocab/InC/1.0/ |
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reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
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Universitat Autònoma de Barcelona |
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Insulin resistance modulates gut microbiota and incretin response remodeling after bariatric surgery in severe obesityPuig, RocíoRodríguez-Peña, M-MarHernández-Montoliu, LauraAstiarraga, Brenno|||0000-0003-2216-8974Martínez, EvaBalibrea Del Castillo, José María|||0000-0002-0764-7179Llauradó, Gemma|||0000-0002-3237-6366Tarascó, JordiCaballero, AlbertJoaquín, Clara|||0000-0002-9063-4853Puig Domingo, Manuel|||0000-0002-6744-7195Vilarrasa, Nuria|||0000-0003-3188-1990Fernández-Veledo, Sonia|||0000-0003-2906-3788Vendrell, Joan|||0000-0002-6994-6115Pellitero, Silvia|||0000-0002-9510-7251Insulin resistanceIncretinMicrobiotaSevere obesityBariatric surgeryThis study aims to assess the impact of insulin resistance (IR) on gut microbiota (GM) composition, incretin responses, and metabolic outcomes following sleeve gastrectomy (SG) in people with severe obesity who do not have diabetes. Methods: A prospective single-center study encompassed patients with severe obesity and normal glucose tolerance who underwent SG. Participants were stratified into two cohorts based on the magnitude of their insulin resistance state, as determined by the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) index: high-IR (Hi-IR; HOMA-IR 95th percentile) and low-IR (Lo-IR; HOMA-IR < 25th percentile). Body composition measurements, biochemical analyses, and microbiota assessments were performed before and six months post-surgery. Additionally, the responses to a standardized meal tolerance test (MTT) of glucagon-like peptide-1 (GLP-1) and glucagon-like peptide-2 (GLP-2) were evaluated. Results: The study cohort consisted of 18 patients (9 with Hi-IR and 9 with Lo-IR), with a mean age of 48.8 ± 9.2 years and a mean body mass index (BMI) of 45.03 ± 4.82 kg/m². Six months post-surgery, the mean percentage of total weight loss (WL) was 26.5 ± 6%, with both groups exhibiting enhanced secretion of GLP-1 and GLP-2 following MTT. At baseline, participants exhibited distinct microbiota profiles; the Hi-IR group showed a higher relative abundance of Prevotella species, which are previously associated with adverse metabolic and inflammatory profiles. Post-surgery, both groups exhibited positive incretin responses and significant modifications in GM composition. Notably Hi-IR people experienced more 146 pronounced changes in microbial diversity, including increases in Akkermansia and Veillonella species and decreases in Prevotella species. Enhanced GLP-1 and GLP-2 responses were correlated with WL and metabòlic improvement, particularly in the Lo-IR population. Conclusions: These findings underscore the role of GM in metabolic changes and surgical outcomes after SG. Targeting gut microbiota may offer a promising avenue for improving obesity treatment strategies. 22025-01-0120252025-01-01Articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/322281https://dx.doi.org/urn:doi:10.1038/s41366-025-01971-7reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengMinisterio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI14/00228Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI17/01503Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI20/00338Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI23/01133Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI14/00633Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI17/00915Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI20/00114Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI23/01289Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI14/01997Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI17/01556Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI22/01773Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 RTI2018-093919-B-100Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 PID2021-122480OB-584-100"la Caixa" Foundation https://doi.org/10.13039/100010434 100010434Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2021/SGR-01409Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2021/SGR-00089open accesshttp://purl.org/coar/access_right/c_abf2Aquest material està protegit per drets d'autor i/o drets afins. Podeu utilitzar aquest material en funció del que permet la legislació de drets d'autor i drets afins d'aplicació al vostre cas. Per a d'altres usos heu d'obtenir permís del(s) titular(s) de drets.https://rightsstatements.org/vocab/InC/1.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3222812026-06-06T12:50:31Z |
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15,812429 |