Diagnostic challenges in chronic inflammatory demyelinating polyradiculoneuropathy

Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) consists of a spectrum of autoimmune diseases of the peripheral nerves, causing weakness and sensory symptoms. Diagnosis often is challenging, because of the heterogeneous presentation and both mis- and underdiagnosis are common. Nerve...

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Autores: Eftimov, Filip|||0000-0002-0146-0776, Lucke, Ilse M., Querol, Luis|||0000-0002-4289-8264, Rajabally, Yusuf Ali|||0000-0002-7170-8343, Verhamme, Camiel
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:283583
Acceso en línea:https://ddd.uab.cat/record/283583
https://dx.doi.org/urn:doi:10.1093/BRAIN/AWAA265
Access Level:acceso abierto
Palabra clave:CIDP
Diagnostic accuracy
Diagnostic pitfalls
Misdiagnosis
Underdiagnosis
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spelling Diagnostic challenges in chronic inflammatory demyelinating polyradiculoneuropathyEftimov, Filip|||0000-0002-0146-0776Lucke, Ilse M.Querol, Luis|||0000-0002-4289-8264Rajabally, Yusuf Ali|||0000-0002-7170-8343Verhamme, CamielCIDPDiagnostic accuracyDiagnostic pitfallsMisdiagnosisUnderdiagnosisChronic inflammatory demyelinating polyradiculoneuropathy (CIDP) consists of a spectrum of autoimmune diseases of the peripheral nerves, causing weakness and sensory symptoms. Diagnosis often is challenging, because of the heterogeneous presentation and both mis- and underdiagnosis are common. Nerve conduction study (NCS) abnormalities suggestive of demyelination are mandatory to fulfil the diagnostic criteria. On the one hand, performance and interpretation of NCS can be difficult and none of these demyelinating findings are specific for CIDP. On the other hand, not all patients will be detected despite the relatively high sensitivity of NCS abnormalities. The electrodiagnostic criteria can be supplemented with additional diagnostic tests such as CSF examination, MRI, nerve biopsy, and somatosensory evoked potentials. However, the evidence for each of these additional diagnostic tests is limited. Studies are often small without the use of a clinically relevant control group. None of the findings are specific for CIDP, meaning that the results of the diagnostic tests should be carefully interpreted. In this update we will discuss the pitfalls in diagnosing CIDP and the value of newly introduced diagnostic tests such as nerve ultrasound and testing for autoantibodies, which are not yet part of the guidelines.Universitat Autònoma de Barcelona 22021-01-0120212021-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/283583https://dx.doi.org/urn:doi:10.1093/BRAIN/AWAA265reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2835832026-06-06T12:50:31Z
dc.title.none.fl_str_mv Diagnostic challenges in chronic inflammatory demyelinating polyradiculoneuropathy
title Diagnostic challenges in chronic inflammatory demyelinating polyradiculoneuropathy
spellingShingle Diagnostic challenges in chronic inflammatory demyelinating polyradiculoneuropathy
Eftimov, Filip|||0000-0002-0146-0776
CIDP
Diagnostic accuracy
Diagnostic pitfalls
Misdiagnosis
Underdiagnosis
title_short Diagnostic challenges in chronic inflammatory demyelinating polyradiculoneuropathy
title_full Diagnostic challenges in chronic inflammatory demyelinating polyradiculoneuropathy
title_fullStr Diagnostic challenges in chronic inflammatory demyelinating polyradiculoneuropathy
title_full_unstemmed Diagnostic challenges in chronic inflammatory demyelinating polyradiculoneuropathy
title_sort Diagnostic challenges in chronic inflammatory demyelinating polyradiculoneuropathy
dc.creator.none.fl_str_mv Eftimov, Filip|||0000-0002-0146-0776
Lucke, Ilse M.
Querol, Luis|||0000-0002-4289-8264
Rajabally, Yusuf Ali|||0000-0002-7170-8343
Verhamme, Camiel
author Eftimov, Filip|||0000-0002-0146-0776
author_facet Eftimov, Filip|||0000-0002-0146-0776
Lucke, Ilse M.
Querol, Luis|||0000-0002-4289-8264
Rajabally, Yusuf Ali|||0000-0002-7170-8343
Verhamme, Camiel
author_role author
author2 Lucke, Ilse M.
Querol, Luis|||0000-0002-4289-8264
Rajabally, Yusuf Ali|||0000-0002-7170-8343
Verhamme, Camiel
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv CIDP
Diagnostic accuracy
Diagnostic pitfalls
Misdiagnosis
Underdiagnosis
topic CIDP
Diagnostic accuracy
Diagnostic pitfalls
Misdiagnosis
Underdiagnosis
description Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) consists of a spectrum of autoimmune diseases of the peripheral nerves, causing weakness and sensory symptoms. Diagnosis often is challenging, because of the heterogeneous presentation and both mis- and underdiagnosis are common. Nerve conduction study (NCS) abnormalities suggestive of demyelination are mandatory to fulfil the diagnostic criteria. On the one hand, performance and interpretation of NCS can be difficult and none of these demyelinating findings are specific for CIDP. On the other hand, not all patients will be detected despite the relatively high sensitivity of NCS abnormalities. The electrodiagnostic criteria can be supplemented with additional diagnostic tests such as CSF examination, MRI, nerve biopsy, and somatosensory evoked potentials. However, the evidence for each of these additional diagnostic tests is limited. Studies are often small without the use of a clinically relevant control group. None of the findings are specific for CIDP, meaning that the results of the diagnostic tests should be carefully interpreted. In this update we will discuss the pitfalls in diagnosing CIDP and the value of newly introduced diagnostic tests such as nerve ultrasound and testing for autoantibodies, which are not yet part of the guidelines.
publishDate 2021
dc.date.none.fl_str_mv 2
2021-01-01
2021
2021-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
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dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
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https://dx.doi.org/urn:doi:10.1093/BRAIN/AWAA265
url https://ddd.uab.cat/record/283583
https://dx.doi.org/urn:doi:10.1093/BRAIN/AWAA265
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
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eu_rights_str_mv openAccess
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dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
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