Genistein early in life modifies the arcuate nucleus of the hypothalamus morphology differentially in male and female rats

In the present work we analyzed the effects of postnatal exposure to two doses of genistein (10 μg/g or 50 μg/g) from postnatal (P) day 6 to P13, on the morphology of the arcuate nucleus (Arc). The analyses of Arc coronal brain sections at 90 days showed that the ArcMP had higher values in volume, N...

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Detalhes bibliográficos
Autores: Fernández-García, José Manuel, Carrillo, Beatriz, Tezanos, Patricia, Pinos, Helena, Collado, Paloma
Formato: artículo
Fecha de publicación:2023
País:España
Recursos:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/19443
Acesso em linha:http://hdl.handle.net/20.500.12105/19443
Access Level:acceso abierto
Palavra-chave:Arcuate Nucleus of Hypothalamus
Genistein
Rats
Animals
Female
Male
Hypothalamus
Neurons
Sex Characteristics
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spelling Genistein early in life modifies the arcuate nucleus of the hypothalamus morphology differentially in male and female ratsFernández-García, José ManuelCarrillo, BeatrizTezanos, PatriciaPinos, HelenaCollado, PalomaArcuate Nucleus of HypothalamusGenisteinRatsAnimalsFemaleMaleHypothalamusNeuronsSex CharacteristicsIn the present work we analyzed the effects of postnatal exposure to two doses of genistein (10 μg/g or 50 μg/g) from postnatal (P) day 6 to P13, on the morphology of the arcuate nucleus (Arc). The analyses of Arc coronal brain sections at 90 days showed that the ArcMP had higher values in volume, Nissl-stained neurons and GPER-ir neurons in males than in females and the treatment with genistein abolished these sex differences in most of the parameters studied. Moreover, in males, but not in females, the GPER-ir neurons decreased in the ArcMP but increased in the ArcL with both doses of genistein. In the ArcLP, GPER-ir population increased with the lowest doses and decreased with the highest one in males. Our results confirm that the Arc subdivisions have differential vulnerability to the effects of genistein during development, depending on which neuromorphological parameters, dose and sex are analyzed.ElsevierNational University of Distance Education (España)Instituto de Salud Carlos III20242024-05-1720232023-06-1520232023-06-15research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/20.500.12105/19443reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/194432026-06-12T12:43:37Z
dc.title.none.fl_str_mv Genistein early in life modifies the arcuate nucleus of the hypothalamus morphology differentially in male and female rats
title Genistein early in life modifies the arcuate nucleus of the hypothalamus morphology differentially in male and female rats
spellingShingle Genistein early in life modifies the arcuate nucleus of the hypothalamus morphology differentially in male and female rats
Fernández-García, José Manuel
Arcuate Nucleus of Hypothalamus
Genistein
Rats
Animals
Female
Male
Hypothalamus
Neurons
Sex Characteristics
title_short Genistein early in life modifies the arcuate nucleus of the hypothalamus morphology differentially in male and female rats
title_full Genistein early in life modifies the arcuate nucleus of the hypothalamus morphology differentially in male and female rats
title_fullStr Genistein early in life modifies the arcuate nucleus of the hypothalamus morphology differentially in male and female rats
title_full_unstemmed Genistein early in life modifies the arcuate nucleus of the hypothalamus morphology differentially in male and female rats
title_sort Genistein early in life modifies the arcuate nucleus of the hypothalamus morphology differentially in male and female rats
dc.creator.none.fl_str_mv Fernández-García, José Manuel
Carrillo, Beatriz
Tezanos, Patricia
Pinos, Helena
Collado, Paloma
author Fernández-García, José Manuel
author_facet Fernández-García, José Manuel
Carrillo, Beatriz
Tezanos, Patricia
Pinos, Helena
Collado, Paloma
author_role author
author2 Carrillo, Beatriz
Tezanos, Patricia
Pinos, Helena
Collado, Paloma
author2_role author
author
author
author
dc.contributor.none.fl_str_mv National University of Distance Education (España)
Instituto de Salud Carlos III
dc.subject.none.fl_str_mv Arcuate Nucleus of Hypothalamus
Genistein
Rats
Animals
Female
Male
Hypothalamus
Neurons
Sex Characteristics
topic Arcuate Nucleus of Hypothalamus
Genistein
Rats
Animals
Female
Male
Hypothalamus
Neurons
Sex Characteristics
description In the present work we analyzed the effects of postnatal exposure to two doses of genistein (10 μg/g or 50 μg/g) from postnatal (P) day 6 to P13, on the morphology of the arcuate nucleus (Arc). The analyses of Arc coronal brain sections at 90 days showed that the ArcMP had higher values in volume, Nissl-stained neurons and GPER-ir neurons in males than in females and the treatment with genistein abolished these sex differences in most of the parameters studied. Moreover, in males, but not in females, the GPER-ir neurons decreased in the ArcMP but increased in the ArcL with both doses of genistein. In the ArcLP, GPER-ir population increased with the lowest doses and decreased with the highest one in males. Our results confirm that the Arc subdivisions have differential vulnerability to the effects of genistein during development, depending on which neuromorphological parameters, dose and sex are analyzed.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-06-15
2023
2023-06-15
2024
2024-05-17
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/19443
url http://hdl.handle.net/20.500.12105/19443
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869423375731916800
score 15,811543

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