Patterns of cortical thinning in nondemented Parkinson's disease patients

Background: Clinical variability in the Parkinson's disease phenotype suggests the existence of disease subtypes. We investigated whether distinct anatomical patterns of atrophy can be identified in Parkinson's disease using a hypothesis-free, datadriven approach based on cortical thicknes...

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Authors: Uribe, Carme, Segura i Fàbregas, Bàrbara, Baggio, Hugo César, Abós, Alexandra, Martí Domènech, Ma. Josep, Valldeoriola Serra, Francesc, Compta, Yaroslau, Bargalló Alabart, Núria, Junqué i Plaja, Carme, 1955-
Format: article
Status:Versión aceptada para publicación
Publication Date:2016
Country:España
Institution:Universidad de Barcelona
Repository:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/161344
Online Access:https://hdl.handle.net/2445/161344
Access Level:Open access
Keyword:Malaltia de Parkinson
Malalties neurodegeneratives
Anàlisi de conglomerats
Parkinson's disease
Neurodegenerative Diseases
Cluster analysis
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spelling Patterns of cortical thinning in nondemented Parkinson's disease patientsUribe, CarmeSegura i Fàbregas, BàrbaraBaggio, Hugo CésarAbós, AlexandraMartí Domènech, Ma. JosepValldeoriola Serra, FrancescCompta, YaroslauBargalló Alabart, NúriaJunqué i Plaja, Carme, 1955-Malaltia de ParkinsonMalalties neurodegenerativesAnàlisi de conglomeratsParkinson's diseaseNeurodegenerative DiseasesCluster analysisBackground: Clinical variability in the Parkinson's disease phenotype suggests the existence of disease subtypes. We investigated whether distinct anatomical patterns of atrophy can be identified in Parkinson's disease using a hypothesis-free, datadriven approach based on cortical thickness data. Methods: T1-weighted 3-tesla MRI and a comprehensive neuropsychological assessment were performed in a sample of 88 nondemented Parkinson's disease patients and 31 healthy controls. We performed a hierarchical cluster analysis of imaging data using Ward's linkage method. A general linear model with cortical thickness data was used to compare clustering groups. Results: We observed 3 patterns of cortical thinning in patients when compared with healthy controls. Pattern 1 (n530, 34.09%) consisted of cortical atrophy in bilateral precentral gyrus, inferior and superior parietal lobules, cuneus, posterior cingulate, and parahippocampal gyrus. These patients showed worse cognitive performance when compared with controls and the other 2 patterns. Pattern 2 (n529, 32.95%) consisted of cortical atrophy involving occipital and frontal as well as superior parietal areas and included patients with younger age at onset. Finally, in pattern 3 (n529, 32.95%), there was no detectable cortical thinning. Patients in the 3 patterns did not differ in disease duration, motor severity, dopaminergic medication doses, or presence of mild cognitive impairment. Conclusions: Three cortical atrophy subtypes were identified in nondemented Parkinson's disease patients: (1) parieto-temporal pattern of atrophy with worse cognitive performance, (2) occipital and frontal cortical atrophy and younger disease onset, and (3) patients without detectable cortical atrophy. These findings may help identify prognosis markers in Parkinson's disease. VC 2016 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder SocietyWiley2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/161344Articles publicats en revistes (Medicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1002/mds.26590Movement Disorders, 2016, vol. 31, num. 5, p. 699-708https://doi.org/10.1002/mds.26590cc-by (c) International Parkinson and Movement Disorder Society, 2016http://creativecommons.org/licenses/by/4.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1613442026-05-27T06:46:51Z
dc.title.none.fl_str_mv Patterns of cortical thinning in nondemented Parkinson's disease patients
title Patterns of cortical thinning in nondemented Parkinson's disease patients
spellingShingle Patterns of cortical thinning in nondemented Parkinson's disease patients
Uribe, Carme
Malaltia de Parkinson
Malalties neurodegeneratives
Anàlisi de conglomerats
Parkinson's disease
Neurodegenerative Diseases
Cluster analysis
title_short Patterns of cortical thinning in nondemented Parkinson's disease patients
title_full Patterns of cortical thinning in nondemented Parkinson's disease patients
title_fullStr Patterns of cortical thinning in nondemented Parkinson's disease patients
title_full_unstemmed Patterns of cortical thinning in nondemented Parkinson's disease patients
title_sort Patterns of cortical thinning in nondemented Parkinson's disease patients
dc.creator.none.fl_str_mv Uribe, Carme
Segura i Fàbregas, Bàrbara
Baggio, Hugo César
Abós, Alexandra
Martí Domènech, Ma. Josep
Valldeoriola Serra, Francesc
Compta, Yaroslau
Bargalló Alabart, Núria
Junqué i Plaja, Carme, 1955-
author Uribe, Carme
author_facet Uribe, Carme
Segura i Fàbregas, Bàrbara
Baggio, Hugo César
Abós, Alexandra
Martí Domènech, Ma. Josep
Valldeoriola Serra, Francesc
Compta, Yaroslau
Bargalló Alabart, Núria
Junqué i Plaja, Carme, 1955-
author_role author
author2 Segura i Fàbregas, Bàrbara
Baggio, Hugo César
Abós, Alexandra
Martí Domènech, Ma. Josep
Valldeoriola Serra, Francesc
Compta, Yaroslau
Bargalló Alabart, Núria
Junqué i Plaja, Carme, 1955-
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Malaltia de Parkinson
Malalties neurodegeneratives
Anàlisi de conglomerats
Parkinson's disease
Neurodegenerative Diseases
Cluster analysis
topic Malaltia de Parkinson
Malalties neurodegeneratives
Anàlisi de conglomerats
Parkinson's disease
Neurodegenerative Diseases
Cluster analysis
description Background: Clinical variability in the Parkinson's disease phenotype suggests the existence of disease subtypes. We investigated whether distinct anatomical patterns of atrophy can be identified in Parkinson's disease using a hypothesis-free, datadriven approach based on cortical thickness data. Methods: T1-weighted 3-tesla MRI and a comprehensive neuropsychological assessment were performed in a sample of 88 nondemented Parkinson's disease patients and 31 healthy controls. We performed a hierarchical cluster analysis of imaging data using Ward's linkage method. A general linear model with cortical thickness data was used to compare clustering groups. Results: We observed 3 patterns of cortical thinning in patients when compared with healthy controls. Pattern 1 (n530, 34.09%) consisted of cortical atrophy in bilateral precentral gyrus, inferior and superior parietal lobules, cuneus, posterior cingulate, and parahippocampal gyrus. These patients showed worse cognitive performance when compared with controls and the other 2 patterns. Pattern 2 (n529, 32.95%) consisted of cortical atrophy involving occipital and frontal as well as superior parietal areas and included patients with younger age at onset. Finally, in pattern 3 (n529, 32.95%), there was no detectable cortical thinning. Patients in the 3 patterns did not differ in disease duration, motor severity, dopaminergic medication doses, or presence of mild cognitive impairment. Conclusions: Three cortical atrophy subtypes were identified in nondemented Parkinson's disease patients: (1) parieto-temporal pattern of atrophy with worse cognitive performance, (2) occipital and frontal cortical atrophy and younger disease onset, and (3) patients without detectable cortical atrophy. These findings may help identify prognosis markers in Parkinson's disease. VC 2016 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society
publishDate 2016
dc.date.none.fl_str_mv 2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/161344
url https://hdl.handle.net/2445/161344
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1002/mds.26590
Movement Disorders, 2016, vol. 31, num. 5, p. 699-708
https://doi.org/10.1002/mds.26590
dc.rights.none.fl_str_mv cc-by (c) International Parkinson and Movement Disorder Society, 2016
http://creativecommons.org/licenses/by/4.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) International Parkinson and Movement Disorder Society, 2016
http://creativecommons.org/licenses/by/4.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.301603

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