The enduring enigma of sporadic chorea: A single center case series

Chorea can have a wide variety of causes including neurodegenerative, pharmacological, structural, metabolic, infectious, immunologic and paraneoplastic processes. We reviewed the clinical records of patients with apparently sporadic choreic movements and no relevant family history, who presented to...

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Autores: García Ruiz-Espiga, Pedro José, Feliz, Lola Diaz, Feliz, Cici E., Lorda Sánchez, Isabel, Ávila Fernández, Almudena, Blanco Kelly, Fiona, Trujillo Tiebas, María José, Del Val, Javier, Navas Vinagre, Inma
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/719188
Acceso en línea:http://hdl.handle.net/10486/719188
https://dx.doi.org/10.5334/tohm.800
Access Level:acceso abierto
Palabra clave:hereditary chorea
secondary chorea
sporadic chorea
Medicina
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spelling The enduring enigma of sporadic chorea: A single center case seriesGarcía Ruiz-Espiga, Pedro JoséFeliz, Lola DiazFeliz, Cici E.Lorda Sánchez, IsabelÁvila Fernández, AlmudenaBlanco Kelly, FionaTrujillo Tiebas, María JoséDel Val, JavierNavas Vinagre, Inmahereditary choreasecondary choreasporadic choreaMedicinaChorea can have a wide variety of causes including neurodegenerative, pharmacological, structural, metabolic, infectious, immunologic and paraneoplastic processes. We reviewed the clinical records of patients with apparently sporadic choreic movements and no relevant family history, who presented to our neurology department (Hospital Fundación Jimenez Diaz) between 1991 and 2022. We detected 38 cases of apparent sporadic chorea (ASC); Our analysis revealed 5 cases of genetic chorea (including 3 cases with Huntington´s disease) while 6 cases were autoimmune/hematological; 6 drug-related chorea, 5 metabolic-vascular, 5 due to miscellaneous conditions and 4 were of mixed etiology. No clear etiology was identified in 8 cases. The differential diagnosis of ASC is extensive and challenging. Highlights • Chorea can have a wide variety of genetic and sporadic causes • We reviewed the clinical records of patients with apparently sporadic chorea (ASC), who presented to our neurology department over the last 30 years • We detected 38 cases of apparent ASC; Our analysis revealed a wide array of different sporadic conditions and 5 cases of genetic chorea • The differential diagnosis of ASC is extensive and challenging. Highlights • Chorea can have a wide variety of genetic and sporadic causes • We reviewed the clinical records of patients with apparently sporadic chorea (ASC), who presented to our neurology department over the last 30 years • We detected 38 cases of apparent ASC; Our analysis revealed a wide array of different sporadic conditions and 5 cases of genetic chorea • The differential diagnosis of ASC is extensive and challengingPedro J Garcia-Ruiz received personal compensation as a consultant/scientific advisory board from Italfarmaco, Britannia, Bial, Esteve, Stada and Zambon and speaking honoraria from Italfarmaco, Zambon, Bial, Esteve, Stada and Abbvie. Lola Diaz-Feliz received speaking honoraria from Bial and Abbvie. Javier del Val, Cici E Feliz, Inmaculada Navas, Isabel Lorda Sanchez, Almudena Avila Fernandez, Fiona Blanco Kelly and Maria Jose Trujillo Tiebas: The authors declare that there are no additional disclosures to reportUbiquity PressDepartamento de MedicinaFacultad de Medicina20232023-09-07research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/719188https://dx.doi.org/10.5334/tohm.800reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/7191882026-06-23T12:46:27Z
dc.title.none.fl_str_mv The enduring enigma of sporadic chorea: A single center case series
title The enduring enigma of sporadic chorea: A single center case series
spellingShingle The enduring enigma of sporadic chorea: A single center case series
García Ruiz-Espiga, Pedro José
hereditary chorea
secondary chorea
sporadic chorea
Medicina
title_short The enduring enigma of sporadic chorea: A single center case series
title_full The enduring enigma of sporadic chorea: A single center case series
title_fullStr The enduring enigma of sporadic chorea: A single center case series
title_full_unstemmed The enduring enigma of sporadic chorea: A single center case series
title_sort The enduring enigma of sporadic chorea: A single center case series
dc.creator.none.fl_str_mv García Ruiz-Espiga, Pedro José
Feliz, Lola Diaz
Feliz, Cici E.
Lorda Sánchez, Isabel
Ávila Fernández, Almudena
Blanco Kelly, Fiona
Trujillo Tiebas, María José
Del Val, Javier
Navas Vinagre, Inma
author García Ruiz-Espiga, Pedro José
author_facet García Ruiz-Espiga, Pedro José
Feliz, Lola Diaz
Feliz, Cici E.
Lorda Sánchez, Isabel
Ávila Fernández, Almudena
Blanco Kelly, Fiona
Trujillo Tiebas, María José
Del Val, Javier
Navas Vinagre, Inma
author_role author
author2 Feliz, Lola Diaz
Feliz, Cici E.
Lorda Sánchez, Isabel
Ávila Fernández, Almudena
Blanco Kelly, Fiona
Trujillo Tiebas, María José
Del Val, Javier
Navas Vinagre, Inma
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Medicina
Facultad de Medicina
dc.subject.none.fl_str_mv hereditary chorea
secondary chorea
sporadic chorea
Medicina
topic hereditary chorea
secondary chorea
sporadic chorea
Medicina
description Chorea can have a wide variety of causes including neurodegenerative, pharmacological, structural, metabolic, infectious, immunologic and paraneoplastic processes. We reviewed the clinical records of patients with apparently sporadic choreic movements and no relevant family history, who presented to our neurology department (Hospital Fundación Jimenez Diaz) between 1991 and 2022. We detected 38 cases of apparent sporadic chorea (ASC); Our analysis revealed 5 cases of genetic chorea (including 3 cases with Huntington´s disease) while 6 cases were autoimmune/hematological; 6 drug-related chorea, 5 metabolic-vascular, 5 due to miscellaneous conditions and 4 were of mixed etiology. No clear etiology was identified in 8 cases. The differential diagnosis of ASC is extensive and challenging. Highlights • Chorea can have a wide variety of genetic and sporadic causes • We reviewed the clinical records of patients with apparently sporadic chorea (ASC), who presented to our neurology department over the last 30 years • We detected 38 cases of apparent ASC; Our analysis revealed a wide array of different sporadic conditions and 5 cases of genetic chorea • The differential diagnosis of ASC is extensive and challenging. Highlights • Chorea can have a wide variety of genetic and sporadic causes • We reviewed the clinical records of patients with apparently sporadic chorea (ASC), who presented to our neurology department over the last 30 years • We detected 38 cases of apparent ASC; Our analysis revealed a wide array of different sporadic conditions and 5 cases of genetic chorea • The differential diagnosis of ASC is extensive and challenging
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-09-07
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/719188
https://dx.doi.org/10.5334/tohm.800
url http://hdl.handle.net/10486/719188
https://dx.doi.org/10.5334/tohm.800
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Ubiquity Press
publisher.none.fl_str_mv Ubiquity Press
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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