Characterization of the microvascular cerebral blood flow response to obstructive apneic events during night sleep

Obstructive apnea causes periodic changes in cerebral and systemic hemodynamics, which may contribute to the increased risk of cerebrovascular disease of patients with obstructive sleep apnea (OSA) syndrome. The improved understanding of the consequences of an apneic event on the brain perfusion may...

Descripción completa

Detalles Bibliográficos
Autores: Zirak, P., Gregori-Pla, C., Blanco, I., Fortuna, A., Cotta, G., Bramon, P., Serra, I., Mola, A., Solà-Soler, J., Giraldo-Giraldo, B.F., Durduran, T., Mayos, M.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2072/446138
Acceso en línea:http://hdl.handle.net/2072/446138
Access Level:acceso abierto
Palabra clave:51
id ES_ec9d1f1da17d8a06cec3ceb5227525f2
oai_identifier_str oai:recercat.cat:2072/446138
network_acronym_str ES
network_name_str España
repository_id_str
spelling Characterization of the microvascular cerebral blood flow response to obstructive apneic events during night sleepZirak, P.Gregori-Pla, C.Blanco, I.Fortuna, A.Cotta, G.Bramon, P.Serra, I.Mola, A.Solà-Soler, J.Giraldo-Giraldo, B.F.Durduran, T.Mayos, M.51Obstructive apnea causes periodic changes in cerebral and systemic hemodynamics, which may contribute to the increased risk of cerebrovascular disease of patients with obstructive sleep apnea (OSA) syndrome. The improved understanding of the consequences of an apneic event on the brain perfusion may improve our knowledge of these consequences and then allow for the development of preventive strategies. Our aim was to characterize the typical microvascular, cortical cerebral blood flow (CBF) changes in an OSA population during an apneic event. Sixteen patients (age 58±8years, 75% male) with a high risk of severe OSA were measured with a polysomnography device and with diffuse correlation spectroscopy (DCS) during one night of sleep with 1365 obstructive apneic events detected. All patients were later confirmed to suffer from severe OSA syndrome with a mean of 83±15 apneas and hypopneas per hour. DCS has been shown to be able to characterize the microvascular CBF response to each event with a sufficient contrast-to-noise ratio to reveal its dynamics. It has also revealed that an apnea causes a peak increase of microvascular CBF (30±17%) at the end of the event followed by a drop (-20±12%) similar to what was observed in macrovascular CBF velocity of the middle cerebral artery. This study paves the way for the utilization of DCS for further studies on these populations. © The Authors.SPIE2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion12 p.application/pdfhttp://hdl.handle.net/2072/446138RECERCAT (Dipòsit de la Recerca de Catalunya)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)Inglésinfo:eu-repo/semantics/openAccessoai:recercat.cat:2072/4461382026-05-29T05:05:01Z
dc.title.none.fl_str_mv Characterization of the microvascular cerebral blood flow response to obstructive apneic events during night sleep
title Characterization of the microvascular cerebral blood flow response to obstructive apneic events during night sleep
spellingShingle Characterization of the microvascular cerebral blood flow response to obstructive apneic events during night sleep
Zirak, P.
51
title_short Characterization of the microvascular cerebral blood flow response to obstructive apneic events during night sleep
title_full Characterization of the microvascular cerebral blood flow response to obstructive apneic events during night sleep
title_fullStr Characterization of the microvascular cerebral blood flow response to obstructive apneic events during night sleep
title_full_unstemmed Characterization of the microvascular cerebral blood flow response to obstructive apneic events during night sleep
title_sort Characterization of the microvascular cerebral blood flow response to obstructive apneic events during night sleep
dc.creator.none.fl_str_mv Zirak, P.
Gregori-Pla, C.
Blanco, I.
Fortuna, A.
Cotta, G.
Bramon, P.
Serra, I.
Mola, A.
Solà-Soler, J.
Giraldo-Giraldo, B.F.
Durduran, T.
Mayos, M.
author Zirak, P.
author_facet Zirak, P.
Gregori-Pla, C.
Blanco, I.
Fortuna, A.
Cotta, G.
Bramon, P.
Serra, I.
Mola, A.
Solà-Soler, J.
Giraldo-Giraldo, B.F.
Durduran, T.
Mayos, M.
author_role author
author2 Gregori-Pla, C.
Blanco, I.
Fortuna, A.
Cotta, G.
Bramon, P.
Serra, I.
Mola, A.
Solà-Soler, J.
Giraldo-Giraldo, B.F.
Durduran, T.
Mayos, M.
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv 51
topic 51
description Obstructive apnea causes periodic changes in cerebral and systemic hemodynamics, which may contribute to the increased risk of cerebrovascular disease of patients with obstructive sleep apnea (OSA) syndrome. The improved understanding of the consequences of an apneic event on the brain perfusion may improve our knowledge of these consequences and then allow for the development of preventive strategies. Our aim was to characterize the typical microvascular, cortical cerebral blood flow (CBF) changes in an OSA population during an apneic event. Sixteen patients (age 58±8years, 75% male) with a high risk of severe OSA were measured with a polysomnography device and with diffuse correlation spectroscopy (DCS) during one night of sleep with 1365 obstructive apneic events detected. All patients were later confirmed to suffer from severe OSA syndrome with a mean of 83±15 apneas and hypopneas per hour. DCS has been shown to be able to characterize the microvascular CBF response to each event with a sufficient contrast-to-noise ratio to reveal its dynamics. It has also revealed that an apnea causes a peak increase of microvascular CBF (30±17%) at the end of the event followed by a drop (-20±12%) similar to what was observed in macrovascular CBF velocity of the middle cerebral artery. This study paves the way for the utilization of DCS for further studies on these populations. © The Authors.
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/2072/446138
url http://hdl.handle.net/2072/446138
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 12 p.
application/pdf
dc.publisher.none.fl_str_mv SPIE
publisher.none.fl_str_mv SPIE
dc.source.none.fl_str_mv RECERCAT (Dipòsit de la Recerca de Catalunya)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869423329802190848
score 15,811543

Similares en LA Referencia