Fragmentation of contaminant and endogenous DNA in ancient samples determined by shotgun sequencing; prospects for human palaeogenomics

Despite the successful retrieval of genomes from past remains, the prospects for human palaeogenomics remain unclear because of the difficulty of distinguishing contaminant from endogenous DNA sequences. Previous sequence data generated on high-throughput sequencing platforms indicate that fragmenta...

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Detalles Bibliográficos
Autores: García Garcerà, M., Gigli, E., Sánchez Quinto, Federico, Ramírez, Oscar, Calafell, Francesc, Civit Vives, Sergi, Lalueza Fox, Carles, 1965-
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2011
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/43561
Acceso en línea:https://hdl.handle.net/2445/43561
Access Level:acceso abierto
Palabra clave:ADN fòssil
ADN
Paleobiologia
Fossil DNA
DNA
Paleobiology
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spelling Fragmentation of contaminant and endogenous DNA in ancient samples determined by shotgun sequencing; prospects for human palaeogenomicsGarcía Garcerà, M.Gigli, E.Sánchez Quinto, FedericoRamírez, OscarCalafell, FrancescCivit Vives, SergiLalueza Fox, Carles, 1965-ADN fòssilADNPaleobiologiaFossil DNADNAPaleobiologyDespite the successful retrieval of genomes from past remains, the prospects for human palaeogenomics remain unclear because of the difficulty of distinguishing contaminant from endogenous DNA sequences. Previous sequence data generated on high-throughput sequencing platforms indicate that fragmentation of ancient DNA sequences is a characteristic trait primarily arising due to depurination processes that create abasic sites leading to DNA breaks.Public Library of Science (PLoS)2011info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/43561Articles publicats en revistes (Genètica, Microbiologia i Estadística)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0024161PLoS One, 2011, vol. 6, num. 8, p. e24161http://dx.doi.org/10.1371/journal.pone.0024161cc-by (c) García Garcerà, M. et al., 2011http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/435612026-05-27T06:46:51Z
dc.title.none.fl_str_mv Fragmentation of contaminant and endogenous DNA in ancient samples determined by shotgun sequencing; prospects for human palaeogenomics
title Fragmentation of contaminant and endogenous DNA in ancient samples determined by shotgun sequencing; prospects for human palaeogenomics
spellingShingle Fragmentation of contaminant and endogenous DNA in ancient samples determined by shotgun sequencing; prospects for human palaeogenomics
García Garcerà, M.
ADN fòssil
ADN
Paleobiologia
Fossil DNA
DNA
Paleobiology
title_short Fragmentation of contaminant and endogenous DNA in ancient samples determined by shotgun sequencing; prospects for human palaeogenomics
title_full Fragmentation of contaminant and endogenous DNA in ancient samples determined by shotgun sequencing; prospects for human palaeogenomics
title_fullStr Fragmentation of contaminant and endogenous DNA in ancient samples determined by shotgun sequencing; prospects for human palaeogenomics
title_full_unstemmed Fragmentation of contaminant and endogenous DNA in ancient samples determined by shotgun sequencing; prospects for human palaeogenomics
title_sort Fragmentation of contaminant and endogenous DNA in ancient samples determined by shotgun sequencing; prospects for human palaeogenomics
dc.creator.none.fl_str_mv García Garcerà, M.
Gigli, E.
Sánchez Quinto, Federico
Ramírez, Oscar
Calafell, Francesc
Civit Vives, Sergi
Lalueza Fox, Carles, 1965-
author García Garcerà, M.
author_facet García Garcerà, M.
Gigli, E.
Sánchez Quinto, Federico
Ramírez, Oscar
Calafell, Francesc
Civit Vives, Sergi
Lalueza Fox, Carles, 1965-
author_role author
author2 Gigli, E.
Sánchez Quinto, Federico
Ramírez, Oscar
Calafell, Francesc
Civit Vives, Sergi
Lalueza Fox, Carles, 1965-
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv ADN fòssil
ADN
Paleobiologia
Fossil DNA
DNA
Paleobiology
topic ADN fòssil
ADN
Paleobiologia
Fossil DNA
DNA
Paleobiology
description Despite the successful retrieval of genomes from past remains, the prospects for human palaeogenomics remain unclear because of the difficulty of distinguishing contaminant from endogenous DNA sequences. Previous sequence data generated on high-throughput sequencing platforms indicate that fragmentation of ancient DNA sequences is a characteristic trait primarily arising due to depurination processes that create abasic sites leading to DNA breaks.
publishDate 2011
dc.date.none.fl_str_mv 2011
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/43561
url https://hdl.handle.net/2445/43561
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0024161
PLoS One, 2011, vol. 6, num. 8, p. e24161
http://dx.doi.org/10.1371/journal.pone.0024161
dc.rights.none.fl_str_mv cc-by (c) García Garcerà, M. et al., 2011
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) García Garcerà, M. et al., 2011
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLoS)
publisher.none.fl_str_mv Public Library of Science (PLoS)
dc.source.none.fl_str_mv Articles publicats en revistes (Genètica, Microbiologia i Estadística)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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