Psoriasis: From Pathogenesis to Pharmacological and Nano-Technological-Based Therapeutics

Research in the pathogenesis of inflammatory skin diseases, such as skin dermatitis and psoriasis, has experienced some relevant breakthroughs in recent years. The understanding of age-related factors, gender, and genetic predisposition of these multifactorial diseases has been instrumental for the...

Full description

Bibliographic Details
Authors: Gironés Petit, Robert, Cano Fernández, Amanda, Ortiz Rodrigo, Alba, Espina García, Marta, Prat Aixelà, Josefa, Muñoz Juncosa, Montserrat, Severino, Patrícia, Souto, Eliana B., García López, María Luisa, Pujol Cubells, Montserrat, Sánchez-López, E. (Elena)
Format: article
Status:Published version
Publication Date:2021
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/177455
Online Access:https://hdl.handle.net/2445/177455
Access Level:Open access
Keyword:Malalties de la pell
Psoriasi
Dermatitis
Skin diseases
Psoriasis
id ES_ec900b06ff0f5eb5899fee2c28539b62
oai_identifier_str oai:recercat.cat:2445/177455
network_acronym_str ES
network_name_str España
repository_id_str
spelling Psoriasis: From Pathogenesis to Pharmacological and Nano-Technological-Based TherapeuticsGironés Petit, RobertCano Fernández, AmandaOrtiz Rodrigo, AlbaEspina García, MartaPrat Aixelà, JosefaMuñoz Juncosa, MontserratSeverino, PatríciaSouto, Eliana B.García López, María LuisaPujol Cubells, MontserratSánchez-López, E. (Elena)Malalties de la pellPsoriasiDermatitisSkin diseasesPsoriasisDermatitisResearch in the pathogenesis of inflammatory skin diseases, such as skin dermatitis and psoriasis, has experienced some relevant breakthroughs in recent years. The understanding of age-related factors, gender, and genetic predisposition of these multifactorial diseases has been instrumental for the development of new pharmacological and technological treatment approaches. In this review, we discuss the molecular mechanisms behind the pathological features of psoriasis, also addressing the currently available treatments and novel therapies that are under clinical trials. Innovative therapies developed over the last 10 years have been researched. In this area, advantages of nanotechnological approaches to provide an effective drug concentration in the disease site are highlighted, together with microneedles as innovative candidates for drug delivery systems in psoriasis and other inflammatory chronic skin diseases. View Full-Text Keywords: skin inflammatory diseases; psoriasis; psoriasis versus atopic dermatitis; biodegradable nanoparticles; microneedles; clinical trialsMDPI2021202120212021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/177455Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/ijms22094983International Journal of Molecular Sciences, 2021, vol. 22, num. 9, p. 4983https://doi.org/10.3390/ijms22094983cc-by (c) Gironés Petit, Robert et al., 2021https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1774552026-05-29T05:05:01Z
dc.title.none.fl_str_mv Psoriasis: From Pathogenesis to Pharmacological and Nano-Technological-Based Therapeutics
title Psoriasis: From Pathogenesis to Pharmacological and Nano-Technological-Based Therapeutics
spellingShingle Psoriasis: From Pathogenesis to Pharmacological and Nano-Technological-Based Therapeutics
Gironés Petit, Robert
Malalties de la pell
Psoriasi
Dermatitis
Skin diseases
Psoriasis
Dermatitis
title_short Psoriasis: From Pathogenesis to Pharmacological and Nano-Technological-Based Therapeutics
title_full Psoriasis: From Pathogenesis to Pharmacological and Nano-Technological-Based Therapeutics
title_fullStr Psoriasis: From Pathogenesis to Pharmacological and Nano-Technological-Based Therapeutics
title_full_unstemmed Psoriasis: From Pathogenesis to Pharmacological and Nano-Technological-Based Therapeutics
title_sort Psoriasis: From Pathogenesis to Pharmacological and Nano-Technological-Based Therapeutics
dc.creator.none.fl_str_mv Gironés Petit, Robert
Cano Fernández, Amanda
Ortiz Rodrigo, Alba
Espina García, Marta
Prat Aixelà, Josefa
Muñoz Juncosa, Montserrat
Severino, Patrícia
Souto, Eliana B.
García López, María Luisa
Pujol Cubells, Montserrat
Sánchez-López, E. (Elena)
author Gironés Petit, Robert
author_facet Gironés Petit, Robert
Cano Fernández, Amanda
Ortiz Rodrigo, Alba
Espina García, Marta
Prat Aixelà, Josefa
Muñoz Juncosa, Montserrat
Severino, Patrícia
Souto, Eliana B.
García López, María Luisa
Pujol Cubells, Montserrat
Sánchez-López, E. (Elena)
author_role author
author2 Cano Fernández, Amanda
Ortiz Rodrigo, Alba
Espina García, Marta
Prat Aixelà, Josefa
Muñoz Juncosa, Montserrat
Severino, Patrícia
Souto, Eliana B.
García López, María Luisa
Pujol Cubells, Montserrat
Sánchez-López, E. (Elena)
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Malalties de la pell
Psoriasi
Dermatitis
Skin diseases
Psoriasis
Dermatitis
topic Malalties de la pell
Psoriasi
Dermatitis
Skin diseases
Psoriasis
Dermatitis
description Research in the pathogenesis of inflammatory skin diseases, such as skin dermatitis and psoriasis, has experienced some relevant breakthroughs in recent years. The understanding of age-related factors, gender, and genetic predisposition of these multifactorial diseases has been instrumental for the development of new pharmacological and technological treatment approaches. In this review, we discuss the molecular mechanisms behind the pathological features of psoriasis, also addressing the currently available treatments and novel therapies that are under clinical trials. Innovative therapies developed over the last 10 years have been researched. In this area, advantages of nanotechnological approaches to provide an effective drug concentration in the disease site are highlighted, together with microneedles as innovative candidates for drug delivery systems in psoriasis and other inflammatory chronic skin diseases. View Full-Text Keywords: skin inflammatory diseases; psoriasis; psoriasis versus atopic dermatitis; biodegradable nanoparticles; microneedles; clinical trials
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/177455
url https://hdl.handle.net/2445/177455
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/ijms22094983
International Journal of Molecular Sciences, 2021, vol. 22, num. 9, p. 4983
https://doi.org/10.3390/ijms22094983
dc.rights.none.fl_str_mv cc-by (c) Gironés Petit, Robert et al., 2021
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Gironés Petit, Robert et al., 2021
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869423325442211840
score 15,812429

Similar Items